Pragmatic Options for Antiretrovirals Delivery in Africa is a Phase III parallel‑group, open‑label, multi‑country, multi‑centre randomised controlled trial evaluating the effectiveness, safety and implementability of new and simplified anti-retroviral therapy for long-term HIV treatment.   The trial is coordinated by the University of St Andrews, with support from the University of Liverpool and Università degli Studi di Torino, and is being conducted in Uganda, Kenya, Côte d’Ivoire, and Zimbabwe to compare this regimen with standard first‑line treatment in adults who are already virologically suppressed. Feasibility, safety, and cost‑effectiveness will also be assessed to inform potential integration of this regimen into routine HIV care.

​

Partners

• University of St Andrews, UK – Coordinator
• Infectious Diseases Institute Limited, Uganda – Sponsor and Scientific lead
• University of Zimbabwe, Zimbabwe
• MOI University, Kenya
• Association PAC-CI, Ivory Coast
• University of Liverpool, UK
• Universita Degli Studi de Torino, Italy