University of St Andrews

Mackenzie Institute for Early Diagnosis

EBED 2024 – Programme 

Wednesday 29 May

1200-1300Arrival & Lunch
1300-1315Welcome and introduction from Prof. Peter Donnelly
1315-1415Setting the Scene: what could success look like for the introduction of new diagnostic tests?
Patient Representative - Anne Fearfull
Industry Representative - Andreas Halner, Oxford Cancer Analytics (OXcan)
Journal Representative - Helen Macdonald, The British Medical Journal
1415-1530Theoretical Considerations
Dr. Margaret McCartney, University of St Andrews, Senior Lecturer. Freelance writer and broadcaster
Prof. John Brodersen, University of Copenhagen, Department of Public Health
30 mins moderated panel discussion of 1st 2 sessions
1600-1645Abstract Session - Elevator Pitches
Theoretical Considerations
Gamuchirai Pamela Gwaza: Enhancing Early Diagnosis through Integrated Approaches: Practical Insights for Designing Interventions in LMICs - An Expert Consensus
Huw Llewelyn: Assessing the use of tests for early diagnosis: predicting at what stage of disease progression the probability of benefit from treatment exceeds harm
Clinical Perspective
Ritah Nakiboneka: Deploying host transcriptional markers for diagnosis of tuberculosis

Andrew Hall: The International Multicentre Project Auditing COVID-19 in Trauma & Orthopaedics (IMPACT): Using routinely-collected and audit-derived health data to evaluate and predict the effects of Coronavirus Disease 2019 on patients with a hip fracture
Rishma Maini: Integrating liquid biopsies into Rapid Cancer Diagnostic Services
University of St Andrews, St Andrews, United Kingdom

Patient Perspective
Simon Baldwin: Birmingham Self-test Report 1: Review of rapid self-test diagnostics sold in supermarkets and chemists in the UK: their descriptions, manufacturers, distributors, and regulators.
Ridhi Agarwal: Birmingham Self-test Report 2: Are the statements of intended use and indicated medical actions for rapid self-test diagnostics sold in supermarkets and chemists appropriate?
Bethany Hillier: Birmingham Self-test Report 3: What is the evidence base for claims of accuracy for rapid self-test diagnostics sold in UK retail settings?

Jon Deeks: Birmingham Self-test Report 4: Are the equipment, sampling, and instructions of rapid self-test diagnostics sold in UK retail settings correct, usable and safe, and are documents readable and in line with national and international guidelines?

Policy and Regulation
Oscar Khawar: "Guidelines and regulations applicable to vitro diagnostic tests in the UK: a scoping review"
1700-1830Clinical Perspective
Prof. Carl Heneghan, University of Oxford, Centre for Evidence-Based medicine
Prof. Susan Moug, University of Glasgow, School of Medicine, Dentistry and Nursing
Prof. Alex Richter, University of Birmingham, Institute of Immunology & Immunotherapy
1830Drinks Reception in the Gateway, followed by walking tour of St Andrews led by University Students

Thursday 30 May

0715-Beach run/swim with Dr. Margaret McCartney & Prof. Frank Sullivan – Meet at Gateway Building
09-0930Networking coffee time, pastries, and bacon rolls
0930-1030Policy and Regulations
Prof. Jon Deeks, University of Birmingham, Institute of Applied Health Research
Dr. Stuart Hogarth, University of Cambridge, Sociology Research
1100-1200Economic Issues
Prof. Rebecca Fitzgerald, University of Cambridge, Department of Oncology
Prof. Bethany Shinkins, University of Warwick Medical School
1200-1315Lunch and networking
1315-1430Oral Abstract Session - Theoretical considerations
Martha Elwenspoek: Creating evidence-based optimal testing strategies for monitoring long-term conditions in primary care
Katie Charlwood: What is the impact of regular monitoring with specific blood tests in people with long term conditions on patient outcomes? Trial emulation using routinely collected primary care data.
Jacqueline Dinnes: Assessing the value of diagnostic tests: evaluation of a framework for identifying and organising test effects
Sian Taylor-Phillips: Intermediate endpoints as sufficient surrogates for cancer-specific mortality in cancer screening trials: A systematic review and meta-analysis

Stephen Bradley: Interpreting diagnostic accuracy studies based on retrospective routinely collected data

Katerina-Vanessa Savva: Real world implementation of the Biomarker Toolkit: a Tool aiming to quantifiably assess biomarker utility and guide development
1500-1600Oral Abstract Session - Clinical & Patient Perspective
Clare Turnbull: Polygenic risk stratification for breast, colorectal and prostate cancer screening in the UK: integration of multiple national routinely collected cancer datasets for modelling of potential impact on cancer-specific mortality
Frank Sullivan: 5 year mortality in a Randomized Controlled Trial of an autoantibody biomarker for Lung cancer.
Obaid Kousha: Pragmatic and scalable diabetic retinopathy screening for lower resource settings: Binocular indirect ophthalmoscopy versus a retinal camera, including Artificial Intelligence (AI) interpretation in Indonesia

Alexandra Brandt Ryborg Jønsson: Logics of Time and Diagnosis
1600-1730Meet the expert Sessions FS
1. Associate Prof. Brian Nicholson, Nuffield Department of Primary Care Health Symplify Sciences, University of Oxford
a. How should we evaluate novel cancer
2. Prof. Clare Turnbull, The Institute of Cancer Research Polygenic testing
a. What can polygenic testing contribute to ED
3. Prof. Jon Deeks,, University of Birmingham, Institute of Applied Health Research
a. Pioneering Innovations: Direct-to-Consumer Tests in Modern Healthcare Pathways
4. Frank Sullivan, Biomarkers
a. A doctoral training programme in Early Diagnosis?
5. Chris Peters, Biomarkers
a. Why so few biomarkers make it into clinical practice.
1730-1800Tour of Medicine Building
1900Conference dinner

Friday 31 May

0900-0930Networking coffee time
0930-1030Oral Abstract Session - Clinical Perspective & Policy & Regulation

Sarah Mills: Developing A Risk Prediction Tools For Near Term Mortality In Patients Who Present To Unscheduled Care In Scotland

Clare Davenport: Developing guidance for the evaluation, regulation, marketing, and monitoring of Direct to Consumer Tests (DTCTs)- ‘GUIDE DTCTs’

Allyson Pollock: Global burden of disease estimates for Major Depressive Disorder: instruments used in studies to measure prevalence of  MDD not designed for that purpose, contribute to  risk of  over-diagnosis and over-treatment.

James Larkin: Payments to healthcare organisations reported by the medical device industry in Europe from 2017 to 2019: an observational study
1030-1200Feedback from Meet the experts small group discussions - Identifying gaps and how to take forward
1200-1300Summary and Future Planning
1300-1400Lunch, Safe journey home