Our research includes the development of diagnostic and predictive biomarkers for cardiovascular disease, specifically quantitative analysis of proteins in blood plasma to investigate proteomic changes underpinning heart disease (Stewart).

We investigate the molecular mechanisms of heart failure and the generation of fatal arrhythmias with the aim to discover novel targets in the treatment of the failing heart (Pitt) and we also focus on the role of the kidneys in blood pressure control with a particular focus on ion and solute transport across the renal epithelia (Mansley).

Moreover, we have a particular interest in how essential metal ions, such as Zn2+, Ca2+ and Co2+ are transported through the blood and how their mishandling by the body can lead to cardiovascular and vascular disease (Pitt and Stewart).

Principal Investigators