{"id":7044,"date":"2026-03-24T12:25:29","date_gmt":"2026-03-24T12:25:29","guid":{"rendered":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/?page_id=7044"},"modified":"2026-05-21T10:18:31","modified_gmt":"2026-05-21T09:18:31","slug":"poa","status":"publish","type":"page","link":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/clinicaltrials\/poa\/","title":{"rendered":"POA"},"content":{"rendered":"

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Pragmatic Options for Antiretovirals Delivery in Africa<\/a><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”3_4,1_4″ _builder_version=”4.27.6″ _module_preset=”default” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”none” custom_padding=”2px|||||” global_colors_info=”{}”][et_pb_column type=”3_4″ _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Main Intro Text” _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

Pragmatic Options for Antiretrovirals Delivery in Africa is a Phase III parallel\u2011group, open\u2011label, multi\u2011country, multi\u2011centre randomised controlled trial evaluating the effectiveness, safety and implementability of new and simplified anti-retroviral therapy for long-term HIV treatment.\u00a0\u00a0<\/span> The trial is coordinated by the University of St Andrews, with support from the University of Liverpool and Universit\u00e0 degli Studi di Torino, and is being conducted in Uganda, Kenya, C\u00f4te d\u2019Ivoire, and Zimbabwe to compare this regimen with standard first\u2011line treatment in adults who are already virologically suppressed. Feasibility, safety, and cost\u2011effectiveness will also be assessed to inform potential integration of this regimen into routine HIV care.<\/p>\n

\u200b<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-content\/uploads\/sites\/50\/2026\/04\/POA.png” alt=”POA Logo” title_text=”POA” align=”center” _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.6″ _module_preset=”default” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”none” custom_padding=”2px||3px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_divider _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.5″ _module_preset=”default” custom_padding=”3px||2px|||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.5″ _module_preset=”default” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”none” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”||25px|||” global_colors_info=”{}”]<\/p>\n

Funders<\/h2>\n

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This project is funded by:<\/p>\n

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Partners<\/h2>\n

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\u2022 University of St Andrews<\/a>, UK – Coordinator
\u2022 Infectious Diseases Institute Limited<\/a>, Uganda – Sponsor and Scientific lead
\u2022 University of Zimbabwe<\/a>, Zimbabwe
\u2022 MOI University<\/a>, Kenya
\u2022 Association PAC-CI<\/a>, Ivory Coast
\u2022 University of Liverpool<\/a>, UK
\u2022 Universita Degli Studi de Torino<\/a>, Italy<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” module_alignment=”center” global_colors_info=”{}”]\t

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<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.5″ _module_preset=”default” custom_padding=”2px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.5″ _module_preset=”default” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”none” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][et_pb_divider _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_divider][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”]<\/p>\n

Team<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ use_custom_gutter=”on” gutter_width=”2″ make_equal=”on” _builder_version=”4.27.5″ _module_preset=”default” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”none” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.27.5″ _module_preset=”default” box_shadow_style=”preset1″ global_colors_info=”{}”][et_pb_image src=”https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-content\/uploads\/sites\/50\/2020\/03\/monitor_0000_Layer-3.jpg” alt=”Dr Derek Sloan” title_text=”Dr Derek Sloan” _builder_version=”4.27.6″ _module_preset=”default” width=”120px” custom_margin=”-20px|||-20px|false|false” border_radii=”on|120px|120px|120px|120px” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” custom_margin=”-90px|10px|30px|120px|false|false” global_colors_info=”{}”]<\/p>\n

Dr Derek Sloan<\/h3>\n

University of St Andrews<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.5″ _module_preset=”default” box_shadow_style=”preset1″ global_colors_info=”{}”][et_pb_image src=”https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-content\/uploads\/sites\/50\/2024\/07\/Julie-Anderson-002.png” title_text=”Julie Anderson (002)” _builder_version=”4.27.6″ _module_preset=”default” width=”120px” custom_margin=”-20px|||-20px|false|false” border_radii=”on|120px|120px|120px|120px” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” custom_margin=”-90px|10px|30px|120px|false|false” global_colors_info=”{}”]<\/p>\n

Julie Anderson<\/h3>\n

University of St Andrews<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.5″ _module_preset=”default” box_shadow_style=”preset1″ global_colors_info=”{}”][et_pb_image src=”https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-content\/uploads\/sites\/50\/2024\/07\/Lesley-Ferrier-002.png” title_text=”Lesley Ferrier (002)” _builder_version=”4.27.6″ _module_preset=”default” width=”120px” custom_margin=”-20px|||-20px|false|false” border_radii=”on|120px|120px|120px|120px” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” custom_margin=”-90px|10px|30px|120px|false|false” global_colors_info=”{}”]<\/p>\n

Lesley Ferrier<\/h3>\n

University of St Andrews<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ use_custom_gutter=”on” gutter_width=”2″ make_equal=”on” _builder_version=”4.27.5″ _module_preset=”default” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”none” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.27.5″ _module_preset=”default” box_shadow_style=”preset1″ global_colors_info=”{}”][et_pb_image src=”https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-content\/uploads\/sites\/50\/2026\/04\/Borok.png” alt=”Margaret Borok” title_text=”Borok” _builder_version=”4.27.6″ _module_preset=”default” width=”120px” custom_margin=”-20px|||-20px|false|false” border_radii=”on|120px|120px|120px|120px” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” custom_margin=”-90px|10px|30px|120px|false|false” global_colors_info=”{}”]<\/p>\n

Prof Margaret Borok<\/h3>\n

University of Zimbabwe<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.5″ _module_preset=”default” box_shadow_style=”preset1″ global_colors_info=”{}”][et_pb_image src=”https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-content\/uploads\/sites\/50\/2026\/04\/castelnuvo.jpg” title_text=”castelnuvo” _builder_version=”4.27.6″ _module_preset=”default” width=”120px” custom_margin=”-20px|||-20px|false|false” border_radii=”on|120px|120px|120px|120px” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” custom_margin=”-90px|10px|30px|120px|false|false” global_colors_info=”{}”]<\/p>\n

Dr Barbara Castelnuovo<\/h3>\n

Infectious Disease Institute, Uganda<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.5″ _module_preset=”default” box_shadow_style=”preset1″ global_colors_info=”{}”][et_pb_image src=”https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-content\/uploads\/sites\/50\/2026\/04\/Albert.jpg” title_text=”Albert” _builder_version=”4.27.5″ _module_preset=”default” width=”120px” custom_margin=”-20px|||-20px|false|false” border_radii=”on|120px|120px|120px|120px” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” custom_margin=”-90px|10px|30px|120px|false|false” global_colors_info=”{}”]<\/p>\n

Dr Albert Kla Minga<\/h3>\n

PAC-CI,\u00a0C\u00f4te d\u2019Ivoire<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ use_custom_gutter=”on” gutter_width=”2″ make_equal=”on” _builder_version=”4.27.5″ _module_preset=”default” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”none” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.27.5″ _module_preset=”default” box_shadow_style=”preset1″ global_colors_info=”{}”][et_pb_image src=”https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-content\/uploads\/sites\/50\/2026\/04\/PAC-CI-Raoul-Moh-Photo.jpg” title_text=”PAC-CI – Raoul Moh – Photo” _builder_version=”4.27.5″ _module_preset=”default” width=”120px” custom_margin=”-20px|||-20px|false|false” border_radii=”on|120px|120px|120px|120px” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” custom_margin=”-90px|10px|30px|120px|false|false” global_colors_info=”{}”]<\/p>\n

Dr. Raoul D. Moh<\/h3>\n

PAC-CI,\u00a0C\u00f4te d\u2019Ivoire<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.5″ _module_preset=”default” box_shadow_style=”preset1″ global_colors_info=”{}”][et_pb_image src=”https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-content\/uploads\/sites\/50\/2026\/04\/Stephane.jpg” title_text=”Stephane” _builder_version=”4.27.5″ _module_preset=”default” width=”120px” custom_margin=”-20px|||-20px|false|false” border_radii=”on|120px|120px|120px|120px” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” custom_margin=”-90px|10px|30px|120px|false|false” global_colors_info=”{}”]<\/p>\n

Dr St\u00e9phane N\u2019GORAN<\/h3>\n

PAC-CI,\u00a0C\u00f4te d\u2019Ivoire<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.5″ _module_preset=”default” box_shadow_style=”preset1″ global_colors_info=”{}”][et_pb_image src=”https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-content\/uploads\/sites\/50\/2026\/04\/Amedeo.jpg” title_text=”Amedeo” _builder_version=”4.27.5″ _module_preset=”default” width=”120px” custom_margin=”-20px|||-20px|false|false” border_radii=”on|120px|120px|120px|120px” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” custom_margin=”-90px|10px|30px|120px|false|false” global_colors_info=”{}”]<\/p>\n

Dr Amedeo De Nicol\u00f2<\/h3>\n

University of Turin,\u00a0Italy<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ use_custom_gutter=”on” gutter_width=”2″ make_equal=”on” _builder_version=”4.27.5″ _module_preset=”default” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”none” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.27.5″ _module_preset=”default” box_shadow_style=”preset1″ global_colors_info=”{}”][et_pb_image src=”https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-content\/uploads\/sites\/50\/2026\/04\/Aggrey-Semeere.jpg” title_text=”Aggrey Semeere” _builder_version=”4.27.5″ _module_preset=”default” width=”120px” custom_margin=”-20px|||-20px|false|false” border_radii=”on|120px|120px|120px|120px” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” custom_margin=”-90px|10px|30px|120px|false|false” global_colors_info=”{}”]<\/p>\n

Dr Aggrey S. Semeere<\/h3>\n

Infectious Disease Institute, Uganda<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.5″ _module_preset=”default” box_shadow_style=”preset1″ global_colors_info=”{}”][et_pb_image src=”https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-content\/uploads\/sites\/50\/2026\/04\/IDI-Christine-Sekaggya-Headshot.jpg” title_text=”IDI – Christine Sekaggya – Headshot” _builder_version=”4.27.5″ _module_preset=”default” width=”120px” custom_margin=”-20px|||-20px|false|false” border_radii=”on|120px|120px|120px|120px” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” custom_margin=”-90px|10px|30px|120px|false|false” global_colors_info=”{}”]<\/p>\n

Dr Christine Sekaggya-Wiltshire<\/h3>\n

Infectious Diseases Institute,\u00a0Uganda<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.5″ _module_preset=”default” box_shadow_style=”preset1″ global_colors_info=”{}”][et_pb_image src=”https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-content\/uploads\/sites\/50\/2026\/04\/Catriona.jpg” title_text=”Catriona” _builder_version=”4.27.5″ _module_preset=”default” width=”120px” custom_margin=”-20px|||-20px|false|false” border_radii=”on|120px|120px|120px|120px” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” custom_margin=”-90px|10px|30px|120px|false|false” global_colors_info=”{}”]<\/p>\n

Prof Catriona Waitt<\/h3>\n

University of Liverpool<\/a><\/p>\n

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Pragmatic Options for Antiretovirals Delivery in AfricaPragmatic Options for Antiretrovirals Delivery in Africa is a Phase III parallel\u2011group, open\u2011label, multi\u2011country, multi\u2011centre randomised controlled trial evaluating the effectiveness, safety and implementability of new and simplified anti-retroviral therapy for long-term HIV treatment.\u00a0\u00a0 The trial is coordinated by the University of St Andrews, with support from the University […]<\/p>\n","protected":false},"author":126,"featured_media":0,"parent":3571,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

Seven year \u20ac185 million project.\u00a0 Thirty partners from 13 countries to deliver an efficient global clinical trials network equipped to implement phase 2 trials that conform to the highest regulatory standards.\u00a0 The goal is to deliver 2 novel phase 2 clinical trials to accelerate the development of new anti-tuberculosis drugs and regimens.\u00a0 The UStAn<\/a> group plays a key role in Work package 7 to develop definitions for biomarkers to monitor treatment effectiveness.<\/p>","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-7044","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2026-06-17 22:31:30","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-json\/wp\/v2\/pages\/7044","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-json\/wp\/v2\/users\/126"}],"replies":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-json\/wp\/v2\/comments?post=7044"}],"version-history":[{"count":4,"href":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-json\/wp\/v2\/pages\/7044\/revisions"}],"predecessor-version":[{"id":7102,"href":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-json\/wp\/v2\/pages\/7044\/revisions\/7102"}],"up":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-json\/wp\/v2\/pages\/3571"}],"wp:attachment":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-json\/wp\/v2\/media?parent=7044"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}