{"id":3876,"date":"2021-09-20T15:26:07","date_gmt":"2021-09-20T14:26:07","guid":{"rendered":"https:\/\/med.st-andrews.ac.uk\/tbtrials\/?page_id=3876"},"modified":"2025-03-24T11:33:22","modified_gmt":"2025-03-24T11:33:22","slug":"panbiome","status":"publish","type":"page","link":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/clinicaltrials\/panbiome\/","title":{"rendered":"PanBIOME"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Sct &#8211; Main&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; transform_translate=&#8221;0px|-37px&#8221; transform_translate_linked=&#8221;off&#8221; width=&#8221;100%&#8221; custom_margin=&#8221;180px||||false|false&#8221; custom_padding=&#8221;|0px|3px||false|false&#8221; box_shadow_style=&#8221;preset1&#8243; box_shadow_spread=&#8221;-80px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;none&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h1>PanBIOME<\/h1>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Txt &#8211; Intro&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_margin=&#8221;|-187px|||false|false&#8221; custom_padding=&#8221;|18px|1px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: justify\">The discovery, evaluation, and implementation of novel tuberculosis biomarkers that improve TB patient management is an important aspect of our research.<\/p>\n<p style=\"text-align: justify\">The PanACEA Biomarkers Expansion (PanBIOME) programme was a biomarker evaluation study of molecular tools for rapid monitoring of patients&#8217; treatment response to TB therapy in three high burden countries in Africa. The study funded by EDCTP was running between 2013 and 2015 in Malawi, Mozambique, and Tanzania, with designated European academic partners in the UK (University of St Andrews) and Germany (University of Munich, LMU).<\/p>\n<p style=\"text-align: justify\">The final outputs of the study were published in The International <a href=\"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2016\/00000020\/00000008\/art00005\">Journal of Tuberculosis and Lung Disease in 2016<\/a> and <a href=\"https:\/\/thorax.bmj.com\/content\/75\/7\/606\">BMJ Thorax in 2020.<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;none&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Participating sites:<\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;none&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Txt &#8211; Map&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"map_wrapper\" id=\"map_wrapper_5505\">\n<div class=\"map_box\" style=\"max-width:2000px\">\n<div class=\"map_aspect_ratio\" style=\"padding-top:56%\" data-padding-top=\"56%\" data-padding-top-mobile=\"\">\n<div class=\"map_container\">\n<div class=\"map_render map_loading\" id=\"map_5505\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li><a href=\"https:\/\/ins.gov.mz\/\">Instituto Nacional de Sa\u00fade, Minist\u00e9rio da Sa\u00fade, Maputo, Mozambique<\/a><\/li>\n<li><a href=\"http:\/\/www.unima.mw\/colleges\/college+of+medicine\">College of Medicine, University of Malawi, Blantyre, Malawi<\/a><\/li>\n<li><a href=\"http:\/\/www.kcri.ac.tz\/about\">Biotechnology Laboratory, Kilimanjaro Clinical Research Institute, Moshi, Tanzania<\/a><\/li>\n<li><a href=\"http:\/\/www.mmrp.org\/\">Mbeya Medical Research Centre, National Institute of Medical Research, Mbeya, Tanzania<\/a><\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;none&#8221; custom_padding=&#8221;||0px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_divider _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;2px|||||&#8221; custom_css_main_element=&#8221;box-shadow:none!important;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;none&#8221; custom_margin=&#8221;-36px|auto||auto||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2 style=\"text-align: left\">About the study<\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;||||||||&#8221; width=&#8221;100%&#8221; max_width=&#8221;100%&#8221; custom_margin=&#8221;|47px||8px|false|false&#8221; custom_padding=&#8221;|4px|||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: justify\">PanBIOME study was a diagnostic clinical trial in which a St Andrews developed molecular test, the <a href=\"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/tb-mbla\/\">Tuberculosis-Molecular Bacterial Load Assay (TB-MBLA)<\/a> has been evaluated. The study put a special emphasis on investigating the performance, feasibility, and reliability of the assay in a multi-site environment. This novel method detects a common RNA species of <em>M. tuberculosis<\/em> called the 16S ribosomal RNA in a real-time reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR) and provides an estimated concentration of the bacilli in a sputum sample.<\/p>\n<p style=\"text-align: justify\">The most impactful outcomes the study showed:<\/p>\n<ul style=\"text-align: justify\">\n<li>The use of the TB-MBLA has eliminated the need for culture methods, allowing researchers to detect and quantify TB bacilli in 98% less time.<\/li>\n<li>The implementation of TB-MBLA in the clinical trial removed the need for a large study sample size, significantly reducing the costs of TB trials for commercial companies and partnerships.<\/li>\n<\/ul>\n<p style=\"text-align: justify\">TB-MBLA showed a high degree of reproducibility across the different study settings and has been rapidly taken up and applied to the design of subsequent clinical trials.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-content\/uploads\/sites\/50\/2021\/09\/PanBIOME2.jpg&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-content\/uploads\/sites\/50\/2021\/09\/PanBIOME3.jpg&#8221; title_text=&#8221;PanBIOME3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PanBIOMEThe discovery, evaluation, and implementation of novel tuberculosis biomarkers that improve TB patient management is an important aspect of our research. The PanACEA Biomarkers Expansion (PanBIOME) programme was a biomarker evaluation study of molecular tools for rapid monitoring of patients&#8217; treatment response to TB therapy in three high burden countries in Africa. The study funded [&hellip;]<\/p>\n","protected":false},"author":157,"featured_media":0,"parent":3571,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-3876","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2026-06-17 22:31:06","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-json\/wp\/v2\/pages\/3876","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-json\/wp\/v2\/users\/157"}],"replies":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-json\/wp\/v2\/comments?post=3876"}],"version-history":[{"count":0,"href":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-json\/wp\/v2\/pages\/3876\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-json\/wp\/v2\/pages\/3571"}],"wp:attachment":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/tbtrials\/wp-json\/wp\/v2\/media?parent=3876"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}