{"id":428,"date":"2021-02-18T14:34:38","date_gmt":"2021-02-18T14:34:38","guid":{"rendered":"http:\/\/med.st-andrews.ac.uk\/staar\/?post_type=project&amp;p=428"},"modified":"2021-02-18T14:34:38","modified_gmt":"2021-02-18T14:34:38","slug":"matthew-holden","status":"publish","type":"project","link":"https:\/\/medicine.st-andrews.ac.uk\/staahr\/project\/matthew-holden\/","title":{"rendered":"Matthew Holden"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.9.10&#8243; custom_margin=&#8221;120px||||false|false&#8221; collapsed=&#8221;off&#8221;][et_pb_row column_structure=&#8221;1_4,3_4&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_image src=&#8221;https:\/\/medicine.st-andrews.ac.uk\/staahr\/wp-content\/uploads\/sites\/49\/2021\/02\/Matthew-Holden.jpg&#8221; alt=&#8221;Matthew Holden&#8221; title_text=&#8221;Matthew Holden&#8221; align=&#8221;center&#8221; admin_label=&#8221;Photo&#8221; _builder_version=&#8221;4.9.2&#8243; _module_preset=&#8221;default&#8221; border_radii=&#8221;on|200px|200px|200px|200px&#8221; border_color_all=&#8221;#0C71C3&#8243;][\/et_pb_image][et_pb_text admin_label=&#8221;Institution Link&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;]<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/www.st-andrews.ac.uk\/\">St Andrews University<\/a><\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Email&#8221; _builder_version=&#8221;4.9.10&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;||||false|false&#8221;]<\/p>\n<p style=\"text-align: center\"><a href=\"mailto:mtgh@st-andrews.ac.uk\">mtgh@st-andrews.ac.uk<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;3_4&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_text _builder_version=&#8221;4.9.10&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;]<\/p>\n<h1>Matthew Holden<\/h1>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3168 alignnone size-full\" src=\"https:\/\/medicine.st-andrews.ac.uk\/staahr\/wp-content\/uploads\/sites\/49\/2021\/05\/20210520-OrangeLine.png\" alt=\"\" width=\"78\" height=\"9\" \/><\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Brief Bio&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;]Since the first bacterial genome was sequenced in 1995, whole genome sequencing (WGS) has provided unprecedented insights into the genetics and evolution of microbial pathogens. Having worked at the Sanger Institute 13 years on a broad range of bacterial genomes, I recently moved to the School of Medicine establishing a pathogenomics group. Research in my group is directed at two main areas: translational genomics, the application of WGS in clinical microbiology; and experimental genomics, using data WGS to investigate the relationship between pathogens\u2019 genotypes and phenotypes.<\/p>\n<p>The research areas that the group are focused on include: developing rapid WGS to combat hospital-associated infections, the molecular basis of antibiotic resistance and virulence, and epidemiology and evolution of methicillin resistant\u00a0<em>S. aureus<\/em>\u00a0(MRSA).<br \/>\n[\/et_pb_text][et_pb_text _builder_version=&#8221;4.9.10&#8243; _module_preset=&#8221;default&#8221;]<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/medicine.st-andrews.ac.uk\/staahr\/network-partners\/projects\/hatua\/\">HATUA<\/a> | <a href=\"https:\/\/medicine.st-andrews.ac.uk\/staahr\/network-partners\/projects\/care\/\">CARE<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>St Andrews University mtgh@st-andrews.ac.ukMatthew Holden Since the first bacterial genome was sequenced in 1995, whole genome sequencing (WGS) has provided unprecedented insights into the genetics and evolution of microbial pathogens. Having worked at the Sanger Institute 13 years on a broad range of bacterial genomes, I recently moved to the School of Medicine establishing a [&hellip;]<\/p>\n","protected":false},"author":126,"featured_media":431,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"project_category":[31],"project_tag":[],"class_list":["post-428","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-st-andrews"],"_links":{"self":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/staahr\/wp-json\/wp\/v2\/project\/428","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/staahr\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/staahr\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/staahr\/wp-json\/wp\/v2\/users\/126"}],"replies":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/staahr\/wp-json\/wp\/v2\/comments?post=428"}],"version-history":[{"count":0,"href":"https:\/\/medicine.st-andrews.ac.uk\/staahr\/wp-json\/wp\/v2\/project\/428\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/staahr\/wp-json\/wp\/v2\/media\/431"}],"wp:attachment":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/staahr\/wp-json\/wp\/v2\/media?parent=428"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/staahr\/wp-json\/wp\/v2\/project_category?post=428"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/staahr\/wp-json\/wp\/v2\/project_tag?post=428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}