PhD Opportunity – Harnessing Bacterial Viruses to Combat Antibiotic-Resistant Infections
Project Title:
Harnessing Bacterial Viruses to Combat Antibiotic-Resistant Infections
Supervisor(s):
Primary Supervisor: Dr Andreas Haag (University of St Andrews, School of Medicine)
Secondary Supervisor: Professor Malcolm F. White (University of St Andrews, School of Biology)
Deadline:
Thursday 15 May 2025
Project Description:
Antimicrobial resistance (AMR) is a major global health crisis, making bacterial infections increasingly difficult to treat. Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), is a leading cause of hospital- and community-acquired infections, with limited treatment options.
This PhD project will investigate a novel strategy to combat S. aureus infections by harnessing bacterial viruses and mobile genetic elements. By leveraging these naturally occurring systems, the project aims to develop a highly targeted antimicrobial approach that could serve as an alternative to traditional antibiotics.
Key objectives will be:
- Identify and optimise molecular components for bacterial killing.
- Engineer targeted genetic elements capable of propagating within S. aureus populations.
- Assess the efficacy of these elements in disrupting S. aureus biofilms and infections.
- Evaluate the safety and specificity of this approach to ensure minimal impact on beneficial microbiota.
The successful candidate will join a dynamic research group at the University of St Andrews, within the School of Medicine. They will receive training in molecular microbiology, synthetic biology, bacterial genetics, phage biology, and bioinformatics. The project will also provide opportunities for collaborations with leading international researchers and participation in workshops, conferences, and outreach activities.
Funding Details:
This 3-year PhD project is open to UK and international students and provides funding to cover stipend and tuition fees.
How to Apply:
Full applications should be made via the University’s online portal.
Applications should include:
- A cover letter detailing research interests and suitability for the project.
- CV or résumé. This should include your personal details with a history of your education and employment to date, including research experience.
- Academic transcripts and degree certificates.
- Contact details of two academic referees.
It is anticipated that the PhD Studentship will start in September 2025. Please make sure your application is complete by 15th May 2025.
Eligibility Criteria:
- A strong undergraduate or master’s degree (2:1 or first class) in microbiology, molecular biology, biotechnology, or a related field.
- Experience with molecular cloning, bacterial genetics, or bioinformatics is desirable but not essential.
- Strong analytical and problem-solving skills, with a keen interest in bacteriophage biology and antimicrobial resistance.
Contact:
Informal enquiries are welcome and can be directed to Dr Andreas Haag at [email protected].
Enquiries about the application process can be directed to Sandra Fleming at [email protected].