PhD Opportunity – EASTBIO: Combining Omics Data and AI Approaches to Dissect the Role of Genetic Factors in Brain Health and Healthy Aging
Project Title:
EASTBIO: Combining Omics Data and AI Approaches to Dissect the Role of Genetic Factors in Brain Health and Healthy Aging
Supervisor(s):
Principal Supervisor: Prof Silvia Paracchini (University of St Andrews, School of Medicine), [email protected]
Co-supervisors: Dr David Harris-Birtill (University of St Andrews, School of Computer Science), [email protected] and Dr Sarah Gregory (Scottish Brain Sciences), [email protected]
Deadline:
Monday 15 December 2025
Project Description:
This project aims to uncover the genetic factors that influence brain health and healthy aging by analysing multi-omics data from large epidemiological cohorts, such as the UK Biobank. By applying AI approaches to genomic, proteomic, imaging, cognitive and demographic data, this project aims to identify key factors that promote healthy brain function and healthy aging. The work will help advance our understanding of how the effects of known risk factors, e.g. genetics associated to neurodevelopmental or neurodegenerative traits, might be mitigated or modulated along developmental trajectories. The results will contribute to the development of innovative frameworks for studying aging trajectories in the general population.
This project offers a unique training opportunity, combining interdisciplinary research in genetics, AI, and neuroimaging and is underpinned by a cross-sector collaboration between the University of St Andrews and Scottish Brain Sciences https://brainsciences.scot/, an innovative company that focusses on early detection of dementia by monitoring brain health and wellbeing. The academic supervisors Prof Silvia Paracchini, a human geneticist with extensive experience in large-scale genomic studies, including cognitive abilities, and Dr David Harris-Birtill, a computer scientist with expertise in AI methods applied to imaging data, are well established collaborators with a strong track record in successfully training students. Specifically for this project they have extensive experience in working with UK Biobank data, brain images and complex longitudinal datasets. Placements at SBS will enhance training hands-on experience with cognitive assessments and brain imaging methodologies, providing unique insight into how such data is collected and processed as well as issues around data ethics and governance. The student will develop critical skills in multi-omics data analysis and integration, AI-driven techniques, as well as learning how to effectively communicate across disciplines and sectors. Regular meetings and project progress reports will allow the students to develop highly effective communication skills and to experience working at the intersection of academic research and industry innovation.
All data required by the project have already been generated so that analyses can start straight away avoiding delays linked to data generation. Training will be provided by experienced supervisors who have established track records in different areas required for the success of this project. Their leading roles within large project including international consortia will provide access to multiple resources as well as opportunities to further develop collaborative networks.
Previous experience in bioinformatics, mathematical modelling and AI methods will be an advantage but is not a requirement.
Funding Details:
This 4 year PhD project is part of a competition funded by EASTBIO BBSRC Doctoral Training Partnership.
This opportunity is open to UK and International students and provides funding to cover stipend at UKRI standard rate and UK level tuition fees. The University of St Andrews will cover the Home-International fee difference.
How to Apply:
Application instructions can be found on the EASTBIO website- How to Apply | EastBio Doctoral Training Partnership | Biology
1) Download and complete the Equality, Diversity and Inclusion survey.
2) Download and complete the EASTBIO Application Form.
3) Please complete an application on our online portal: How to apply – Study at St Andrews – University of St Andrews
4) Select the course ‘PhD with internship’
5) Your online application must include the following documents:
– Completed EASTBIO application form
– Academic Qualifications
– English Language Qualification (if applicable)
– 2 References: this must be completed on the EASTBIO Reference Form, also found on the EASTBIO website
Please download the EASTBIO reference form and send it to your referees. They can either upload it directly to the portal using the automated email they will receive, or they can email it to Rachel at [email protected].
Contact:
Queries on the project can be directed to the project supervisor.
Queries on the application process can be directed to Rachel Horn at [email protected].
UKRI eligibility guidance: Terms and Conditions: View Website International/EU: View Website.