{"id":267,"date":"2024-04-19T10:44:03","date_gmt":"2024-04-19T09:44:03","guid":{"rendered":"https:\/\/medicine.st-andrews.ac.uk\/igh-draft\/?page_id=267"},"modified":"2024-04-23T11:17:35","modified_gmt":"2024-04-23T10:17:35","slug":"combination","status":"publish","type":"page","link":"https:\/\/medicine.st-andrews.ac.uk\/igh\/research\/antimicrobial-resistance\/combination\/","title":{"rendered":"Combination therapy to tackle AMR"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Global Section &#8211; Main Menu&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#0071b3&#8243; min_height=&#8221;38px&#8221; max_height=&#8221;150px&#8221; custom_margin=&#8221;||-20px||false|false&#8221; custom_padding=&#8221;5px||0px||false|false&#8221; saved_tabs=&#8221;all&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; 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admin_label=&#8221;Section &#8211; Breadcrumbs&#8221; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;25px||||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-50px|auto||auto|false|false&#8221; custom_padding=&#8221;10px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][lwp_divi_breadcrumbs home_text=&#8221;IGH&#8221; font_icon=&#8221;&#x35;||divi||400&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; module_font=&#8221;||||||||&#8221; module_font_size=&#8221;16px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; global_module=&#8221;311&#8243;][\/lwp_divi_breadcrumbs][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Title Section&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#FFFFFF&#8221; custom_margin=&#8221;-110px||||false|false&#8221; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_post_title meta=&#8221;off&#8221; featured_image=&#8221;off&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; title_font=&#8221;|700|||||||&#8221; title_font_size=&#8221;35px&#8221; hover_enabled=&#8221;0&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][\/et_pb_post_title][et_pb_text admin_label=&#8221;Intro&#8221; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; header_3_font_size=&#8221;33px&#8221; header_4_line_height=&#8221;1.2em&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Another method of dealing with AMR has been outlined as using combination therapy. This is using more than one antibiotic at once to treat a resistant infection, clearing that infection, and reducing the emergence of new resistance phenotypes.It is understood that increasing the number of antibiotics given to a patient can have several benefits:<\/p>\n<p>From the patient\u2019s point of view the chief benefit is that the concentration of each component of the therapy can be reduced significantly. This reduces the chance of a toxic reaction in the patient while still clearing a highly dangerous infection.<\/p>\n<p>From the scientific and clinical point of view it is known that combination therapies are more difficult for bacteria to evolve resistances to as there are more active agents acting upon each bacterium and the population as a whole.<\/p>\n<p>The third valuable aspect is synergy. Combining effective agents can lead to an effect that is greater than the sum of the parts. This is synergistic antimicrobial action and is the current focus of Dr Hammond and colleagues. Dr Hammond\u2019s lab are using a high throughput method to hunt for synergistic combinations of antimicrobials to combat currently relevant resistant pathogens (the ESKAPE group) and benefit patient outcomes.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#f1f1f1&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Title&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;|700|||||||&#8221; header_2_font=&#8221;|700|||||||&#8221; header_3_font=&#8221;|700|||||||&#8221; header_3_font_size=&#8221;33px&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<h2>Principle Investigator<\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Text &#8211; Robert&#8221; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<!-- pure output start --><!-- pure output start --><style>\n.pureProfileListItem {\n\tdisplay: block;\n\twidth: 100%;\n\tmargin-bottom: 15px;\n}\n\n.pureProfileListItem h3 {\n\tfont-size: calc(0.9 * 1.3em);\n}\n\n.pureProfileListItem h4 {\n\tfont-size: calc(0.9 * 1.1em);\n}\n\n.pureProfileListItem:after {\n  content: \"\";\n  display: table;\n  clear: both;\n}\n\n.pureImage {\n  object-fit: none; \/* Do not scale the image *\/\n  object-position: center; \/* Center the image within the element *\/\n  height: auto;\n  width:50px;\n  height:50px;\n  overflow:hidden;\n  float:left;\n  margin-right: 10px;\n  margin-bottom: 15px;\n}\n.pureTextArea {\n\twidth: 80%;\n\tfloat:left;\n}\n\n\n.pureName {\n\n}\n.pureJob {\n\n}\n.pureContact {\n\tdisplay: block;\n\tfloat:left;\n}\n.purePhone {\n}\n.pureEmail {\n}\n.pureJob {\n}\n.pureProfileKeywords {\n\tfont-style:italic;\n\tdisplay: inline-block;\n\tmargin-bottom: 10px;\n}\n\n\n<\/style><a href=\"https:\/\/research-portal.st-andrews.ac.uk\/en\/persons\/7a5f059f-c6b0-4ff9-83e0-490fe9ce49a6\" target=\"_blank\"><div class=\"pureProfileListItem\"><div class=\"pureImage\"><img decoding=\"async\" src=\"https:\/\/pure.st-andrews.ac.uk\/portal\/files\/324310273\/medium.jpg\" alt=\"rjhh\"><\/div><div class=\"pureTextArea\"><div class=\"pureName\"><h3>Dr Robert Hammond<\/h3><\/div><h4><div class=\"pureJob\">Lecturer<\/div><\/h4><div class=\"pureContact\"><\/div><\/div><\/div><\/a>\n<!-- pure output end -->\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p><div class=\"et_pb_module lwp_divi_breadcrumbs lwp_divi_breadcrumbs_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"lwp-breadcrumbs\"> <span class=\"before\"><\/span> <span vocab=\"https:\/\/schema.org\/\" typeof=\"BreadcrumbList\"><span property=\"itemListElement\" typeof=\"ListItem\"><a property=\"item\" typeof=\"WebPage\" href=\"https:\/\/medicine.st-andrews.ac.uk\/igh\/\" class=\"home\"><span property=\"name\">IGH<\/span><\/a><meta property=\"position\" content=\"1\"><\/span> <span class=\"separator et-pb-icon\">5<\/span> <\/span><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>Another method of dealing with AMR has been outlined as using combination therapy. This is using more than one antibiotic at once to treat a resistant infection, clearing that infection, and reducing the emergence of new resistance phenotypes.It is understood that increasing the number of antibiotics [&hellip;]<\/p>\n","protected":false},"author":126,"featured_media":0,"parent":56,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-267","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/igh\/wp-json\/wp\/v2\/pages\/267","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/igh\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/igh\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/igh\/wp-json\/wp\/v2\/users\/126"}],"replies":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/igh\/wp-json\/wp\/v2\/comments?post=267"}],"version-history":[{"count":0,"href":"https:\/\/medicine.st-andrews.ac.uk\/igh\/wp-json\/wp\/v2\/pages\/267\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/igh\/wp-json\/wp\/v2\/pages\/56"}],"wp:attachment":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/igh\/wp-json\/wp\/v2\/media?parent=267"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}