{"id":65,"date":"2023-12-12T12:42:06","date_gmt":"2023-12-12T12:42:06","guid":{"rendered":"https:\/\/medicine.st-andrews.ac.uk\/cmed-draft\/?page_id=65"},"modified":"2024-05-17T12:35:11","modified_gmt":"2024-05-17T11:35:11","slug":"cancer","status":"publish","type":"page","link":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/research\/cancer\/","title":{"rendered":"Cancer research"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Global Section &#8211; Main Menu&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#0071b3&#8243; min_height=&#8221;38px&#8221; max_height=&#8221;150px&#8221; custom_margin=&#8221;||-20px||false|false&#8221; custom_padding=&#8221;5px||0px||false|false&#8221; saved_tabs=&#8221;all&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; min_height=&#8221;81px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_menu menu_id=&#8221;11&#8243; active_link_color=&#8221;#ffffff&#8221; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; menu_text_color=&#8221;#FFFFFF&#8221; menu_font_size=&#8221;18px&#8221; background_color=&#8221;#0071b3&#8243; background_layout=&#8221;dark&#8221; custom_margin=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_menu][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Section &#8211; Breadcrumbs&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-50px|auto||auto|false|false&#8221; custom_padding=&#8221;10px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][lwp_divi_breadcrumbs home_text=&#8221;CMED&#8221; font_icon=&#8221;&#x35;||divi||400&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; module_font=&#8221;||||||||&#8221; global_module=&#8221;589&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/lwp_divi_breadcrumbs][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Title Section&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#FFFFFF&#8221; custom_margin=&#8221;-110px||||false|false&#8221; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_post_title meta=&#8221;off&#8221; featured_image=&#8221;off&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; title_font=&#8221;|700|||||||&#8221; title_font_size=&#8221;35px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_post_title][et_pb_text admin_label=&#8221;Intro&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Our research generates data from patient samples, such as urine, blood and tissue to better understand who may develop invasive disease, who may forgo invasive treatment and who may respond best to specific therapy; in other words early intervention and personalised medicine (Harrison).\u00a0 The Villar Cortes group particularly focus on the identification of non-conventional metabolites in plasma samples that can be exploited for biomarker discovery in cancer.<\/p>\n<p>The research does not just focus on the cancer and its molecular make up, but also our immunological response (Powis). We develop innovate methodology in digital and molecular pathology, computer vision, and immunology (Harrison, Reynolds, Powis). Our work also identifies novel resistance mechanisms, modes of actions and synergistic combinations of novel drugs being developed for the clinic. Finally, we apply mathematical modelling and machine learning to the large and complex data sets generated to optimise our understanding of disease and to identify novel drug targets (Lynch).<\/p>\n<p>We work with multiple collaborators within the NHS, academia and industry to not only ensure our research is pioneering, but also has strong translatable impact into the clinic.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; height=&#8221;240px&#8221; custom_padding=&#8221;2px|||||&#8221; hover_enabled=&#8221;0&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; background_image=&#8221;https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-content\/uploads\/sites\/64\/2024\/05\/Picture6.jpg&#8221; 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_module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2><b>Principal Investigators<\/b><\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Text &#8211; Andrew&#8221; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<!-- pure output start --><!-- pure output start --><style>\n.pureProfileListItem {\n\tdisplay: block;\n\twidth: 100%;\n\tmargin-bottom: 15px;\n}\n\n.pureProfileListItem h3 {\n\tfont-size: calc(0.9 * 1.3em);\n}\n\n.pureProfileListItem h4 {\n\tfont-size: calc(0.9 * 1.1em);\n}\n\n.pureProfileListItem:after {\n  content: \"\";\n  display: table;\n  clear: both;\n}\n\n.pureImage {\n  object-fit: none; \/* Do not scale the image *\/\n  object-position: center; \/* Center the image within the element *\/\n  height: auto;\n  width:50px;\n  height:50px;\n  overflow:hidden;\n  float:left;\n  margin-right: 10px;\n  margin-bottom: 15px;\n}\n.pureTextArea {\n\twidth: 80%;\n\tfloat:left;\n}\n\n\n.pureName {\n\n}\n.pureJob {\n\n}\n.pureContact {\n\tdisplay: block;\n\tfloat:left;\n}\n.purePhone {\n}\n.pureEmail {\n}\n.pureJob {\n}\n.pureProfileKeywords {\n\tfont-style:italic;\n\tdisplay: inline-block;\n\tmargin-bottom: 10px;\n}\n\n\n<\/style><a href=\"https:\/\/research-portal.st-andrews.ac.uk\/en\/persons\/1e0d86ab-7cfe-46b4-b158-87d385d62cf2\" target=\"_blank\"><div class=\"pureProfileListItem\"><div class=\"pureImage\"><img decoding=\"async\" src=\"https:\/\/pure.st-andrews.ac.uk\/portal\/files\/324308642\/medium.jpg\" alt=\"agl4\"><\/div><div class=\"pureTextArea\"><div class=\"pureName\"><h3>Prof Andrew Lynch<\/h3><\/div><h4><div class=\"pureJob\">Professor of Statistics in Bioscience<\/div><div class=\"pureJob\">Professor<\/div><\/h4><div class=\"pureContact\"><\/div><div class=\"pureContact\"><\/div><\/div><\/div><\/a>\n<!-- pure output end -->\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; 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_builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Text &#8211; Paul&#8221; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<!-- pure output start --><!-- pure output start --><style>\n.pureProfileListItem {\n\tdisplay: block;\n\twidth: 100%;\n\tmargin-bottom: 15px;\n}\n\n.pureProfileListItem h3 {\n\tfont-size: calc(0.9 * 1.3em);\n}\n\n.pureProfileListItem h4 {\n\tfont-size: calc(0.9 * 1.1em);\n}\n\n.pureProfileListItem:after {\n  content: \"\";\n  display: table;\n  clear: both;\n}\n\n.pureImage {\n  object-fit: none; \/* Do not scale the image *\/\n  object-position: center; \/* Center the image within the element *\/\n  height: auto;\n  width:50px;\n  height:50px;\n  overflow:hidden;\n  float:left;\n  margin-right: 10px;\n  margin-bottom: 15px;\n}\n.pureTextArea {\n\twidth: 80%;\n\tfloat:left;\n}\n\n\n.pureName {\n\n}\n.pureJob {\n\n}\n.pureContact {\n\tdisplay: block;\n\tfloat:left;\n}\n.purePhone {\n}\n.pureEmail {\n}\n.pureJob {\n}\n.pureProfileKeywords {\n\tfont-style:italic;\n\tdisplay: inline-block;\n\tmargin-bottom: 10px;\n}\n\n\n<\/style><a href=\"https:\/\/research-portal.st-andrews.ac.uk\/en\/persons\/48ef22da-3545-42bb-b71b-d26a7dd0d331\" target=\"_blank\"><div class=\"pureProfileListItem\"><div class=\"pureImage\"><img decoding=\"async\" src=\"https:\/\/pure.st-andrews.ac.uk\/portal\/files\/324307772\/medium.jpg\" alt=\"vhvc1\"><\/div><div class=\"pureTextArea\"><div class=\"pureName\"><h3>Dr Victor Villar Cortes<\/h3><\/div><h4><\/h4><\/div><\/div><\/a>\n<!-- pure output end -->\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p><div class=\"et_pb_module lwp_divi_breadcrumbs lwp_divi_breadcrumbs_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"lwp-breadcrumbs\"> <span class=\"before\"><\/span> <span vocab=\"https:\/\/schema.org\/\" typeof=\"BreadcrumbList\"><span property=\"itemListElement\" typeof=\"ListItem\"><a property=\"item\" typeof=\"WebPage\" href=\"https:\/\/medicine.st-andrews.ac.uk\/cmed\/\" class=\"home\"><span property=\"name\">CMED<\/span><\/a><meta property=\"position\" content=\"1\"><\/span> <span class=\"separator et-pb-icon\">5<\/span> <\/span><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>Our research generates data from patient samples, such as urine, blood and tissue to better understand who may develop invasive disease, who may forgo invasive treatment and who may respond best to specific therapy; in other words early intervention and personalised medicine (Harrison).\u00a0 The Villar Cortes group [&hellip;]<\/p>\n","protected":false},"author":126,"featured_media":0,"parent":78,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-65","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/pages\/65","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/users\/126"}],"replies":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/comments?post=65"}],"version-history":[{"count":0,"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/pages\/65\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/pages\/78"}],"wp:attachment":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/media?parent=65"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}