{"id":131,"date":"2023-12-12T15:29:36","date_gmt":"2023-12-12T15:29:36","guid":{"rendered":"https:\/\/medicine.st-andrews.ac.uk\/cmed-draft\/?page_id=131"},"modified":"2024-05-16T15:11:31","modified_gmt":"2024-05-16T14:11:31","slug":"human-genetics","status":"publish","type":"page","link":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/research\/human-genetics\/","title":{"rendered":"Human genetics"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Global Section &#8211; Main Menu&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#0071b3&#8243; min_height=&#8221;38px&#8221; max_height=&#8221;150px&#8221; custom_margin=&#8221;||-20px||false|false&#8221; custom_padding=&#8221;5px||0px||false|false&#8221; saved_tabs=&#8221;all&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; min_height=&#8221;81px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_menu menu_id=&#8221;11&#8243; active_link_color=&#8221;#ffffff&#8221; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; menu_text_color=&#8221;#FFFFFF&#8221; menu_font_size=&#8221;18px&#8221; background_color=&#8221;#0071b3&#8243; background_layout=&#8221;dark&#8221; custom_margin=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_menu][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Section &#8211; Breadcrumbs&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-50px|auto||auto|false|false&#8221; custom_padding=&#8221;10px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][lwp_divi_breadcrumbs home_text=&#8221;CMED&#8221; font_icon=&#8221;&#x35;||divi||400&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; module_font=&#8221;||||||||&#8221; global_module=&#8221;589&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/lwp_divi_breadcrumbs][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Title Section&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#FFFFFF&#8221; custom_margin=&#8221;-110px||||false|false&#8221; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_post_title meta=&#8221;off&#8221; featured_image=&#8221;off&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; title_font=&#8221;|700|||||||&#8221; title_font_size=&#8221;35px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_post_title][et_pb_text admin_label=&#8221;Intro&#8221; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>We are studying the genetic basis of complex neurodevelopmental conditions, including dyslexia, language disorders and ADHD (Paracchini, Lynch). By taking part in international collaborations and conducting large genetic screenings, we aim to identify risk factors contributing to disorders. The characterization of these factors provides the basis to investigate disease mechanisms at the cellular level, and to understand the role of genetic variation in gene function and gene expression regulation.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; height=&#8221;240px&#8221; custom_padding=&#8221;2px|||||&#8221; hover_enabled=&#8221;0&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; background_image=&#8221;https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-content\/uploads\/sites\/64\/2024\/05\/Picture13.jpg&#8221; hover_enabled=&#8221;0&#8243; border_width_all=&#8221;2px&#8221; border_color_all=&#8221;#FFFFFF&#8221; global_colors_info=&#8221;{}&#8221; 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_module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2><b>Principal Investigators<\/b><\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Text &#8211; Silvia&#8221; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<!-- pure output start --><!-- pure output start --><style>\n.pureProfileListItem {\n\tdisplay: block;\n\twidth: 100%;\n\tmargin-bottom: 15px;\n}\n\n.pureProfileListItem h3 {\n\tfont-size: calc(0.9 * 1.3em);\n}\n\n.pureProfileListItem h4 {\n\tfont-size: calc(0.9 * 1.1em);\n}\n\n.pureProfileListItem:after {\n  content: \"\";\n  display: table;\n  clear: both;\n}\n\n.pureImage {\n  object-fit: none; \/* Do not scale the image *\/\n  object-position: center; \/* Center the image within the element *\/\n  height: auto;\n  width:50px;\n  height:50px;\n  overflow:hidden;\n  float:left;\n  margin-right: 10px;\n  margin-bottom: 15px;\n}\n.pureTextArea {\n\twidth: 80%;\n\tfloat:left;\n}\n\n\n.pureName {\n\n}\n.pureJob {\n\n}\n.pureContact {\n\tdisplay: block;\n\tfloat:left;\n}\n.purePhone {\n}\n.pureEmail {\n}\n.pureJob {\n}\n.pureProfileKeywords {\n\tfont-style:italic;\n\tdisplay: inline-block;\n\tmargin-bottom: 10px;\n}\n\n\n<\/style><a href=\"https:\/\/research-portal.st-andrews.ac.uk\/en\/persons\/d094635b-fe9c-406a-91c8-58c5663c02f9\" target=\"_blank\"><div class=\"pureProfileListItem\"><div class=\"pureImage\"><img decoding=\"async\" src=\"https:\/\/pure.st-andrews.ac.uk\/portal\/files\/324311899\/medium.jpg\" alt=\"sp58\"><\/div><div class=\"pureTextArea\"><div class=\"pureName\"><h3>Prof Silvia Paracchini<\/h3><\/div><h4><div class=\"pureJob\">Professor of Neurogenetics and Genomics<\/div><\/h4><div class=\"pureContact\"><\/div><\/div><\/div><\/a>\n<!-- pure output end -->\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Text &#8211; Andrew&#8221; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<!-- pure output start --><!-- pure output start --><style>\n.pureProfileListItem {\n\tdisplay: block;\n\twidth: 100%;\n\tmargin-bottom: 15px;\n}\n\n.pureProfileListItem h3 {\n\tfont-size: calc(0.9 * 1.3em);\n}\n\n.pureProfileListItem h4 {\n\tfont-size: calc(0.9 * 1.1em);\n}\n\n.pureProfileListItem:after {\n  content: \"\";\n  display: table;\n  clear: both;\n}\n\n.pureImage {\n  object-fit: none; \/* Do not scale the image *\/\n  object-position: center; \/* Center the image within the element *\/\n  height: auto;\n  width:50px;\n  height:50px;\n  overflow:hidden;\n  float:left;\n  margin-right: 10px;\n  margin-bottom: 15px;\n}\n.pureTextArea {\n\twidth: 80%;\n\tfloat:left;\n}\n\n\n.pureName {\n\n}\n.pureJob {\n\n}\n.pureContact {\n\tdisplay: block;\n\tfloat:left;\n}\n.purePhone {\n}\n.pureEmail {\n}\n.pureJob {\n}\n.pureProfileKeywords {\n\tfont-style:italic;\n\tdisplay: inline-block;\n\tmargin-bottom: 10px;\n}\n\n\n<\/style><a href=\"https:\/\/research-portal.st-andrews.ac.uk\/en\/persons\/1e0d86ab-7cfe-46b4-b158-87d385d62cf2\" target=\"_blank\"><div class=\"pureProfileListItem\"><div class=\"pureImage\"><img decoding=\"async\" src=\"https:\/\/pure.st-andrews.ac.uk\/portal\/files\/324308642\/medium.jpg\" alt=\"agl4\"><\/div><div class=\"pureTextArea\"><div class=\"pureName\"><h3>Prof Andrew Lynch<\/h3><\/div><h4><div class=\"pureJob\">Professor of Statistics in Bioscience<\/div><div class=\"pureJob\">Professor<\/div><\/h4><div class=\"pureContact\"><\/div><div class=\"pureContact\"><\/div><\/div><\/div><\/a>\n<!-- pure output end -->\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p><div class=\"et_pb_module lwp_divi_breadcrumbs lwp_divi_breadcrumbs_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"lwp-breadcrumbs\"> <span class=\"before\"><\/span> <span vocab=\"https:\/\/schema.org\/\" typeof=\"BreadcrumbList\"><span property=\"itemListElement\" typeof=\"ListItem\"><a property=\"item\" typeof=\"WebPage\" href=\"https:\/\/medicine.st-andrews.ac.uk\/cmed\/\" class=\"home\"><span property=\"name\">CMED<\/span><\/a><meta property=\"position\" content=\"1\"><\/span> <span class=\"separator et-pb-icon\">5<\/span> <\/span><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>We are studying the genetic basis of complex neurodevelopmental conditions, including dyslexia, language disorders and ADHD (Paracchini, Lynch). By taking part in international collaborations and conducting large genetic screenings, we aim to identify risk factors contributing to disorders. The characterization of these factors provides the basis to [&hellip;]<\/p>\n","protected":false},"author":126,"featured_media":0,"parent":78,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-131","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/pages\/131","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/users\/126"}],"replies":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/comments?post=131"}],"version-history":[{"count":0,"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/pages\/131\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/pages\/78"}],"wp:attachment":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/media?parent=131"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}