{"id":122,"date":"2023-12-12T15:26:58","date_gmt":"2023-12-12T15:26:58","guid":{"rendered":"https:\/\/medicine.st-andrews.ac.uk\/cmed-draft\/?page_id=122"},"modified":"2024-05-16T15:02:36","modified_gmt":"2024-05-16T14:02:36","slug":"immunology","status":"publish","type":"page","link":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/research\/immunology\/","title":{"rendered":"Immunology"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Global Section &#8211; Main Menu&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#0071b3&#8243; min_height=&#8221;38px&#8221; max_height=&#8221;150px&#8221; custom_margin=&#8221;||-20px||false|false&#8221; custom_padding=&#8221;5px||0px||false|false&#8221; saved_tabs=&#8221;all&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; min_height=&#8221;81px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_menu menu_id=&#8221;11&#8243; active_link_color=&#8221;#ffffff&#8221; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; menu_text_color=&#8221;#FFFFFF&#8221; menu_font_size=&#8221;18px&#8221; background_color=&#8221;#0071b3&#8243; background_layout=&#8221;dark&#8221; custom_margin=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_menu][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Section &#8211; Breadcrumbs&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-50px|auto||auto|false|false&#8221; custom_padding=&#8221;10px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][lwp_divi_breadcrumbs home_text=&#8221;CMED&#8221; font_icon=&#8221;&#x35;||divi||400&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; module_font=&#8221;||||||||&#8221; global_module=&#8221;589&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/lwp_divi_breadcrumbs][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Title Section&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#FFFFFF&#8221; custom_margin=&#8221;-110px||||false|false&#8221; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_post_title meta=&#8221;off&#8221; featured_image=&#8221;off&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; title_font=&#8221;|700|||||||&#8221; title_font_size=&#8221;35px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_post_title][et_pb_text admin_label=&#8221;Intro&#8221; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>The focus of our current research is on the role the immune system plays in various diseases such as inflammatory arthritis of the spine in the form of ankylosing spondylitis and its association with the HLA class I allele HLA-B27 and also in immuno-oncology, where immune responses frequently fail to eradicate tumour cells despite evidence of immune reactivity.<\/p>\n<p>The role played by extracellular vesicles\/exosomes in this process and also as potential diagnostic indicators of cancer are being explored. In addition, the antigenic peptides being presented to cytotoxic T cells during COVID-19 is a new active area under investigation to assist with the development of the next generation of vaccines that will hopefully provide both robust antibody and T cell responses (Powis).<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; height=&#8221;240px&#8221; custom_padding=&#8221;2px|||||&#8221; hover_enabled=&#8221;0&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; background_image=&#8221;https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-content\/uploads\/sites\/64\/2024\/05\/Picture7.jpg&#8221; hover_enabled=&#8221;0&#8243; border_width_all=&#8221;2px&#8221; border_color_all=&#8221;#FFFFFF&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][et_pb_cta _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; background_enable_color=&#8221;off&#8221; min_height=&#8221;240px&#8221; height=&#8221;240px&#8221; max_height=&#8221;240px&#8221; global_colors_info=&#8221;{}&#8221; content__hover_enabled=&#8221;on|hover&#8221; content__hover=&#8221;&#8221; background__hover_enabled=&#8221;on|hover&#8221; background_color__hover=&#8221;rgba(193,0,252,0.16)&#8221; background_enable_color__hover=&#8221;on&#8221;][\/et_pb_cta][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; background_image=&#8221;https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-content\/uploads\/sites\/64\/2024\/05\/Picture8.jpg&#8221; hover_enabled=&#8221;0&#8243; border_width_all=&#8221;2px&#8221; border_color_all=&#8221;#FFFFFF&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][et_pb_cta _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; background_enable_color=&#8221;off&#8221; min_height=&#8221;240px&#8221; height=&#8221;240px&#8221; max_height=&#8221;240px&#8221; global_colors_info=&#8221;{}&#8221; content__hover_enabled=&#8221;on|hover&#8221; content__hover=&#8221;&#8221; background__hover_enabled=&#8221;on|hover&#8221; background_color__hover=&#8221;rgba(193,0,252,0.16)&#8221; background_enable_color__hover=&#8221;on&#8221;][\/et_pb_cta][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; background_image=&#8221;https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-content\/uploads\/sites\/64\/2024\/05\/Picture9.jpg&#8221; hover_enabled=&#8221;0&#8243; border_width_all=&#8221;2px&#8221; border_color_all=&#8221;#FFFFFF&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][et_pb_cta _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; background_enable_color=&#8221;off&#8221; min_height=&#8221;240px&#8221; height=&#8221;240px&#8221; max_height=&#8221;240px&#8221; global_colors_info=&#8221;{}&#8221; content__hover_enabled=&#8221;on|hover&#8221; content__hover=&#8221;&#8221; background__hover_enabled=&#8221;on|hover&#8221; background_color__hover=&#8221;rgba(193,0,252,0.16)&#8221; background_enable_color__hover=&#8221;on&#8221;][\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#f1f1f1&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Title&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;|700|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Principal Investigators<\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Text &#8211; Andrew&#8221; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<!-- pure output start --><!-- pure output start --><style>\n.pureProfileListItem {\n\tdisplay: block;\n\twidth: 100%;\n\tmargin-bottom: 15px;\n}\n\n.pureProfileListItem h3 {\n\tfont-size: calc(0.9 * 1.3em);\n}\n\n.pureProfileListItem h4 {\n\tfont-size: calc(0.9 * 1.1em);\n}\n\n.pureProfileListItem:after {\n  content: \"\";\n  display: table;\n  clear: both;\n}\n\n.pureImage {\n  object-fit: none; \/* Do not scale the image *\/\n  object-position: center; \/* Center the image within the element *\/\n  height: auto;\n  width:50px;\n  height:50px;\n  overflow:hidden;\n  float:left;\n  margin-right: 10px;\n  margin-bottom: 15px;\n}\n.pureTextArea {\n\twidth: 80%;\n\tfloat:left;\n}\n\n\n.pureName {\n\n}\n.pureJob {\n\n}\n.pureContact {\n\tdisplay: block;\n\tfloat:left;\n}\n.purePhone {\n}\n.pureEmail {\n}\n.pureJob {\n}\n.pureProfileKeywords {\n\tfont-style:italic;\n\tdisplay: inline-block;\n\tmargin-bottom: 10px;\n}\n\n\n<\/style><a href=\"https:\/\/research-portal.st-andrews.ac.uk\/en\/persons\/b750d4d9-ea60-4785-9da5-91e07a0dafa0\" target=\"_blank\"><div class=\"pureProfileListItem\"><div class=\"pureImage\"><img decoding=\"async\" src=\"https:\/\/pure.st-andrews.ac.uk\/portal\/files\/324310724\/medium.jpg\" alt=\"sjp10\"><\/div><div class=\"pureTextArea\"><div class=\"pureName\"><h3>Dr Simon Powis<\/h3><\/div><h4><div class=\"pureJob\">Reader<\/div><\/h4><div class=\"pureContact\"><\/div><\/div><\/div><\/a>\n<!-- pure output end -->\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p><div class=\"et_pb_module lwp_divi_breadcrumbs lwp_divi_breadcrumbs_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"lwp-breadcrumbs\"> <span class=\"before\"><\/span> <span vocab=\"https:\/\/schema.org\/\" typeof=\"BreadcrumbList\"><span property=\"itemListElement\" typeof=\"ListItem\"><a property=\"item\" typeof=\"WebPage\" href=\"https:\/\/medicine.st-andrews.ac.uk\/cmed\/\" class=\"home\"><span property=\"name\">CMED<\/span><\/a><meta property=\"position\" content=\"1\"><\/span> <span class=\"separator et-pb-icon\">5<\/span> <\/span><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>The focus of our current research is on the role the immune system plays in various diseases such as inflammatory arthritis of the spine in the form of ankylosing spondylitis and its association with the HLA class I allele HLA-B27 and also in immuno-oncology, where immune responses [&hellip;]<\/p>\n","protected":false},"author":126,"featured_media":0,"parent":78,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-122","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/pages\/122","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/users\/126"}],"replies":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/comments?post=122"}],"version-history":[{"count":0,"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/pages\/122\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/pages\/78"}],"wp:attachment":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/media?parent=122"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}