{"id":112,"date":"2023-12-12T15:23:14","date_gmt":"2023-12-12T15:23:14","guid":{"rendered":"https:\/\/medicine.st-andrews.ac.uk\/cmed-draft\/?page_id=112"},"modified":"2024-05-16T14:57:37","modified_gmt":"2024-05-16T13:57:37","slug":"cardio-research","status":"publish","type":"page","link":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/research\/cardio-research\/","title":{"rendered":"Cardiovascular research"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Global Section &#8211; Main Menu&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#0071b3&#8243; min_height=&#8221;38px&#8221; max_height=&#8221;150px&#8221; custom_margin=&#8221;||-20px||false|false&#8221; custom_padding=&#8221;5px||0px||false|false&#8221; saved_tabs=&#8221;all&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; min_height=&#8221;81px&#8221; 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global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][lwp_divi_breadcrumbs home_text=&#8221;CMED&#8221; font_icon=&#8221;&#x35;||divi||400&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; module_font=&#8221;||||||||&#8221; global_module=&#8221;589&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/lwp_divi_breadcrumbs][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Title Section&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#FFFFFF&#8221; custom_margin=&#8221;-110px||||false|false&#8221; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_post_title meta=&#8221;off&#8221; featured_image=&#8221;off&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; title_font=&#8221;|700|||||||&#8221; title_font_size=&#8221;35px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_post_title][et_pb_text admin_label=&#8221;Intro&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Our research includes the development of diagnostic and predictive biomarkers for cardiovascular disease, specifically quantitative analysis of proteins in blood plasma to investigate proteomic changes underpinning heart disease (Stewart).<\/p>\n<p>We investigate the molecular mechanisms of heart failure and the generation of fatal arrhythmias with the aim to discover novel targets in the treatment of the failing heart (Pitt) and we also focus on the role of the kidneys in blood pressure control with a particular focus on ion and solute transport across the renal epithelia (Mansley).<\/p>\n<p>Moreover, we have a particular interest in how essential metal ions, such as Zn2+, Ca2+ and Co2+ are transported through the blood and how their mishandling by the body can lead to cardiovascular and vascular disease (Pitt and Stewart).<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; 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_module_preset=&#8221;default&#8221; background_image=&#8221;https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-content\/uploads\/sites\/64\/2024\/05\/Picture3.jpg&#8221; border_width_all=&#8221;2px&#8221; border_color_all=&#8221;#FFFFFF&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_cta _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; background_enable_color=&#8221;off&#8221; min_height=&#8221;240px&#8221; height=&#8221;240px&#8221; max_height=&#8221;240px&#8221; global_colors_info=&#8221;{}&#8221; content__hover_enabled=&#8221;on|hover&#8221; content__hover=&#8221;&#8221; background__hover_enabled=&#8221;on|hover&#8221; background_color__hover=&#8221;rgba(193,0,252,0.16)&#8221; background_enable_color__hover=&#8221;on&#8221;][\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#f1f1f1&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Title&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2><strong>Principal Investigators<\/strong><\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Text &#8211; Alan&#8221; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<!-- pure output start --><!-- pure output start --><style>\n.pureProfileListItem {\n\tdisplay: block;\n\twidth: 100%;\n\tmargin-bottom: 15px;\n}\n\n.pureProfileListItem h3 {\n\tfont-size: calc(0.9 * 1.3em);\n}\n\n.pureProfileListItem h4 {\n\tfont-size: calc(0.9 * 1.1em);\n}\n\n.pureProfileListItem:after {\n  content: \"\";\n  display: table;\n  clear: both;\n}\n\n.pureImage {\n  object-fit: none; \/* Do not scale the image *\/\n  object-position: center; \/* Center the image within the element *\/\n  height: auto;\n  width:50px;\n  height:50px;\n  overflow:hidden;\n  float:left;\n  margin-right: 10px;\n  margin-bottom: 15px;\n}\n.pureTextArea {\n\twidth: 80%;\n\tfloat:left;\n}\n\n\n.pureName {\n\n}\n.pureJob {\n\n}\n.pureContact {\n\tdisplay: block;\n\tfloat:left;\n}\n.purePhone {\n}\n.pureEmail {\n}\n.pureJob {\n}\n.pureProfileKeywords {\n\tfont-style:italic;\n\tdisplay: inline-block;\n\tmargin-bottom: 10px;\n}\n\n\n<\/style><a href=\"https:\/\/research-portal.st-andrews.ac.uk\/en\/persons\/1fb1b6f2-516a-4734-8c7c-ac1a3c278f17\" target=\"_blank\"><div class=\"pureProfileListItem\"><div class=\"pureImage\"><img decoding=\"async\" src=\"https:\/\/pure.st-andrews.ac.uk\/portal\/files\/324297309\/medium.jpg\" alt=\"ajs21\"><\/div><div class=\"pureTextArea\"><div class=\"pureName\"><h3>Dr Alan Stewart<\/h3><\/div><h4><div class=\"pureJob\">Reader<\/div><\/h4><div class=\"pureContact\"><\/div><\/div><\/div><\/a>\n<!-- pure output end -->\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; 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_builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Text &#8211; Sam&#8221; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<!-- pure output start --><!-- pure output start --><style>\n.pureProfileListItem {\n\tdisplay: block;\n\twidth: 100%;\n\tmargin-bottom: 15px;\n}\n\n.pureProfileListItem h3 {\n\tfont-size: calc(0.9 * 1.3em);\n}\n\n.pureProfileListItem h4 {\n\tfont-size: calc(0.9 * 1.1em);\n}\n\n.pureProfileListItem:after {\n  content: \"\";\n  display: table;\n  clear: both;\n}\n\n.pureImage {\n  object-fit: none; \/* Do not scale the image *\/\n  object-position: center; \/* Center the image within the element *\/\n  height: auto;\n  width:50px;\n  height:50px;\n  overflow:hidden;\n  float:left;\n  margin-right: 10px;\n  margin-bottom: 15px;\n}\n.pureTextArea {\n\twidth: 80%;\n\tfloat:left;\n}\n\n\n.pureName {\n\n}\n.pureJob {\n\n}\n.pureContact {\n\tdisplay: block;\n\tfloat:left;\n}\n.purePhone {\n}\n.pureEmail {\n}\n.pureJob {\n}\n.pureProfileKeywords {\n\tfont-style:italic;\n\tdisplay: inline-block;\n\tmargin-bottom: 10px;\n}\n\n\n<\/style><a href=\"https:\/\/research-portal.st-andrews.ac.uk\/en\/persons\/c5bf4584-721e-4276-9f05-06c3bd2a40e1\" target=\"_blank\"><div class=\"pureProfileListItem\"><div class=\"pureImage\"><img decoding=\"async\" src=\"https:\/\/pure.st-andrews.ac.uk\/portal\/files\/324310774\/medium.jpg\" alt=\"sjp24\"><\/div><div class=\"pureTextArea\"><div class=\"pureName\"><h3>Dr Samantha Pitt<\/h3><\/div><h4><div class=\"pureJob\">Reader<\/div><\/h4><div class=\"pureContact\"><\/div><\/div><\/div><\/a>\n<!-- pure output end -->\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p><div class=\"et_pb_module lwp_divi_breadcrumbs lwp_divi_breadcrumbs_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"lwp-breadcrumbs\"> <span class=\"before\"><\/span> <span vocab=\"https:\/\/schema.org\/\" typeof=\"BreadcrumbList\"><span property=\"itemListElement\" typeof=\"ListItem\"><a property=\"item\" typeof=\"WebPage\" href=\"https:\/\/medicine.st-andrews.ac.uk\/cmed\/\" class=\"home\"><span property=\"name\">CMED<\/span><\/a><meta property=\"position\" content=\"1\"><\/span> <span class=\"separator et-pb-icon\">5<\/span> <\/span><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>Our research includes the development of diagnostic and predictive biomarkers for cardiovascular disease, specifically quantitative analysis of proteins in blood plasma to investigate proteomic changes underpinning heart disease (Stewart). We investigate the molecular mechanisms of heart failure and the generation of fatal arrhythmias with the aim to [&hellip;]<\/p>\n","protected":false},"author":126,"featured_media":0,"parent":78,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-112","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/pages\/112","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/users\/126"}],"replies":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/comments?post=112"}],"version-history":[{"count":0,"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/pages\/112\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/pages\/78"}],"wp:attachment":[{"href":"https:\/\/medicine.st-andrews.ac.uk\/cmed\/wp-json\/wp\/v2\/media?parent=112"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}