University of St Andrews
 
  
 

Research

Multidisciplinary and collaborative approaches have been central to the continued success of medical research in St Andrews. Internationally recognised research programmes in various aspects of molecular medicine, psychology and community health sciences are currently being promoted and extended.

Strategically planned new staff appointments over the next decade, and our move to new purpose-built research facilities within the new Medical School building will provide the infrastructure and academic environment to ensure the sustained development and expansion of medical research in St Andrews in the future

Research themes

 


Latest Publications (50)

Monsanto Pinheiro, M , Divis, PC, Siner, A, Zainudin, R, Wong, IT, Lu, CW, Singh-Khaira, SK, Millar, SB, Lynch, S, Willmann, M, Singh, B, Krishna, S & Cox Singh, J 2014, ' Disease progression in Plasmodium knowlesi malaria is linked to variation in invasion gene family members ' PLoS Neglected Tropical Diseases , vol 8, no. 8, e3086.
Levin, KA 2014, ' Urban–rural differences in adolescent eating behaviour: a multilevel cross-sectional study of 15-year-olds in Scotland ' Journal of Public Health Nutrition , vol 17, no. 8, pp. 1776-1785.
Gialluisi, A, Newbury, DF, Wilcutt, EG, Olson, RK, DeFries, JC, Brandler, WM, Pennington, BF, Smith, SD, Scerri, TS, Simpson, NH, Luciano, M, Evans, DM, Bates, TC, Stein, JF, Talcott, JB, Monaco, AP , Paracchini, S , Francks, C, Fisher, SE & The SLI Consortium 2014, ' Genome-wide screening for DNA variants associated with reading and language traits ' GENES BRAIN AND BEHAVIOR .
Cavanagh, JP, Hjerde, E , Holden, MTG , Kahlke, T, Klingenberg, C, Flægstad, T, Parkhill, J, Bentley, SD & Sollid, JUE 2014, ' Whole-genome sequencing reveals clonal expansion of multiresistant Staphylococcus haemolyticus in European hospitals ' Journal of Antimicrobial Chemotherapy .
Martin, J, Cooper, M, Hamshere, ML, Pocklington, A, Scherer, SW , Kent, L , Gill, M, Owen, MJ, Williams, N, O'Donovan, MC, Thapar, A & Holmans, P 2014, ' Biological Overlap of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder: Evidence From Copy Number Variants ' Journal of the American Academy of Child and Adolescent Psychiatry , vol 53, no. 7, pp. 761-770.
Bossé, JT, Li, Y, Angen, O, Weinert, LA, Chaudhuri, RR, Holden, MT, Williamson, SM, Maskell, DJ, Tucker, AW, Wren, BW, Rycroft, AN, Langford, PR, on behalf of the BRaDP1T consortium & Holden, M 2014, ' Multiplex PCR Assay for unequivocal differentiation of Actinobacillus pleuropneumoniae serovars 1 to 3, 5 to 8, 10, and 12 ' Journal of Clinical Microbiology , pp. 2380-2385.
McClinton, S, Starr, K, Thomas, R, McLennan, G, McPherson, G, McDonald, A, Lam, T, N'Dow, J, Kilonzo, M, Pickard, R, Anson, K & Burr, J 2014, ' Use of drug therapy in the management of symptomatic ureteric stones in hospitalized adults (SUSPEND), a multicentre, placebo-controlled, randomized trial of a calcium-channel blocker (nifedipine) and an alpha-blocker (tamsulosin): study protocol for a randomized controlled trial ' Trials , vol 15, 238.
Goltsov, A, Deeni, Y, Khalil, HS, Soininen, T, Kyriakidis, S, Hu, H, Langdon, SP , Harrison, DJ & Bown, J 2014, ' Systems analysis of drug-induced receptor tyrosine kinase reprogramming following targeted mono- and combination anti-cancer therapy ' Cells , vol 3, no. 2, pp. 563-591.
Caie, PD, Turnbull, AK, Farrington, SM , Oniscu, A & Harrison, DJ 2014, ' Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer ' Journal of Translational Medicine , vol 12, no. 1, 156.
O'Hare, BA-M , Makuta, I, Chiwaula, L & Bar-Zeev, N 2014, ' Upstream barriers to child mortality reduction: the case of Sub Saharan Africa ' Archives of disease in childhood , vol 99, no. Suppl. 1, A123 .
Rowlands, K , Dunne, L, Dye, S, Aragon-Salamanca, A, Maddox, S, da Cunha, E, Smith, DJB, Bourne, N, Eales, S, Gomez, HL, Smail, I, Alpaslan, M , Clark, CJR , Driver, S , Ibar, E, Ivison, RJ , Robotham, A , Smith, MWL & Valiante, E 2014, ' Herschel(star)-ATLAS: properties of dusty massive galaxies at low and high redshifts ' Monthly Notices of the Royal Astronomical Society , vol 441, no. 2, pp. 1017-1039.
Quaglio, G , Ramsay, A , Harries, AD, Karapiperis, T, Putoto, G, Dye, C, Olesen, OF, Tomson, G & Zachariah, R 2014, ' Calling on Europe to support operational research in low-income and middle-income countries ' The Lancet Global Health , vol 2, no. 6, pp. e308-3310.
Cote, CL, Castonguay, M, Kalujnaia, MS , Cramb, G & Bernatchez, L 2014, ' In absence of local adaptation, plasticity and spatially varying selection rule: a view from genomic reaction norms in a panmictic species (Anguilla rostrata) ' BMC Genomics , vol 15, 403.
Pitt, SJ , Lam, AKM, Rietdorf, K, Galione, A & Sitsapesan, R 2014, ' Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca 2+ ' Science signaling , vol 7, no. 326, ra46.
Harrison, EM, Weinert, LA , Holden, MTG , Welch, JJ, Wilson, K, Morgan, FJE, Harris, SR, Loeffler, A, Boag, AK, Peacock, SJ, Paterson, GK, Waller, AS, Parkhill, J & Holmes, MA 2014, ' A shared population of epidemic methicillin-resistant Staphylococcus aureus 15 circulates in humans and companion animals ' Mbio , vol 5, no. 3, e00985-13 .
Ross, MT, Macrae, C, Scott, J, Renwick, L, Moffat, M, Needham, G, Scott, H, Shippey, B , Jackson, C , Edgar, S, Aitken, D, Evans, P & Irvine, S 2014, ' Core competencies in teaching and training for doctors in Scotland: a review of the literature and stakeholder survey ' Medical Teacher , vol 36, no. 6, pp. 527-538.
Uhlemann, A-C, Dordel, J, Knox, JR, Raven, KE, Parkhill, J , Holden, MTG , Peacock, SJ & Lowy, FD 2014, ' Molecular tracing of the emergence, diversification, and transmission of S. aureus sequence type 8 in a New York community ' Proceedings of the National Academy of Sciences of the United States of America , vol 111, no. 18, pp. 6738–6743.
Obradovic, M , Stewart, AJ , Pitt, SJ , Labudovic-Borovic, M, Sudar, E, Petrovic, V, Zafirovic, S, Maravic-Stojkovic, V, Vasic, V & Isenovic, ER 2014, ' In vivo effects of 17β-estradiol on cardiac Na + /K + -ATPase expression and activity in rat heart ' Molecular and Cellular Endocrinology , vol 388, no. 1-2, pp. 58-68.
Sabiiti, W , Robertson, E, Beale, MA, Johnston, SA, Brouwer, AE, Loyse, A, Jarvis, JN, Gilbert, AS, Fisher, MC, Harrison, TS, May, RC & Bicanic, T 2014, ' Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis ' The Journal of Clinical Investigation , vol 124, no. 5, pp. 2000-8.
Cecil, JE 2014, ' Applying learning theory to improve liking and intake of vegetables in children ' Appetite , vol 76, no. 1 May 2014.
Hart, AB, Gamazon, ER, Engelhardt, BE, Sklar, P, Kähler, AK, Hultman, CM, Sullivan, PF, Neale, BM, Faraone, SV, de Wit, H, Cox, NJ, Palmer, AA, Psychiatric Genomics Consortium: ADHD Subgroup & Kent, L 2014, ' Genetic variation associated with euphorigenic effects of d-amphetamine is associated with diminished risk for schizophrenia and attention deficit hyperactivity disorder ' Proceedings of the National Academy of Sciences of the United States of America , vol 111, no. 16, pp. 5968-73.
Williams, DJ , Re, D & Ozakinci, G 2014, ' Television viewing habits of pre-clinical UK medical undergraduates: Further potential implications for bioethics ' American Journal of Bioethics: Empirical Bioethics , vol 5, no. 2, pp. 55-67.
Bucksch, J , Inchley, J , Hamrik, Z, Finne, E, Kolip, P & HBSC Study Group Germany 2014, ' Trends in television time, non-gaming PC use and moderate-to-vigorous physical activity among German adolescents 2002-2010 ' BMC Public Health , vol 14, no. 1, pp. 351.
Huang, R, Faratian, D, Sims, AH, Wilson, D, Thomas, JS , Harrison, DJ & Langdon, SP 2014, ' Increased STAT1 signaling in endocrine-resistant breast cancer ' PLoS One , vol 9, no. 4, e94226.
Laabei, M, Recker, M, Rudkin, JK, Aldeljawi, M, Gulay, Z, Sloan, TJ, Williams, P, Endres, JL, Bayles, KW, Fey, PD, Yajjala, VK, Widhelm, T, Hawkins, E, Lewis, K, Parfett, S, Scowen, L, Peacock, SJ , Holden, M , Wilson, D, Read, TD, van den Elsen, J, Priest, NK, Feil, EJ, Hurst, LD, Josefsson, E & Massey, RC 2014, ' Predicting the virulence of MRSA from its genome sequence ' Genome Research , vol 24, pp. 839-849.
Dordel, J, Kim, C, Chung, M, Pardos de la Gándara, M , Holden, MTJ , Parkhill, J, de Lencastre, H, Bentley, SD & Tomasz, A 2014, ' Novel determinants of antibiotic resistance: identification of mutated loci in highly methicillin-resistant subpopulations of methicillin-resistant Staphylococcus aureus ' Mbio , vol 5, no. 2, e01000-13 .
Newbury, DF, Monaco, AP & Paracchini, S 2014, ' Reading and language disorders: the importance of both quantity and quality ' Genes , vol 5, no. 2, pp. 285-309.
Ling, CL , Oravcova, K , Beattie, TF , Creer, DD, Dilworth, P, Fulton, NL, Hardie, A, Munro, M, Pond, M, Templeton, K, Webster, D, Workman, S, McHugh, TD & Gillespie, SH 2014, ' Tools for detection of Mycoplasma amphoriforme : a primary respiratory pathogen? ' Journal of Clinical Microbiology , vol 52, no. 4, pp. 1177-1181.
Morales, DR , Jackson, CM , Lipworth, BJ, Donnan, PT & Guthrie, B 2014, ' Adverse respiratory effect of acute β-blocker exposure in asthma: a systematic review and meta-analysis of randomized controlled trials ' Chest , vol 145, no. 4, pp. 779-86.
Greer, SL, Stewart, EA, wilson, I & Donnelly, PD 2014, ' Victory for volunteerism? Scottish Health Board elections and participation in the welfare state ' Social Science and Medicine , vol 106, pp. 221-228.
Simpson, NH, Addis, L, Brandler, WM, Slonims, V, Clark, A, Watson, J, Scerri, TS, Hennessy, ER, Bolton, PF, Conti-Ramsden, G, Fairfax, BP, Knight, JC, Stein, J, Talcott, JB, O'Hare, A, Baird, G , Paracchini, S , Fisher, SE, Newbury, DF & Consortium, S 2014, ' Increased prevalence of sex chromosome aneuploidies in specific language impairment and dyslexia ' Developmental Medicine and Child Neurology , vol 56, no. 4, pp. 346-353.
Nudel, R, Simpson, NH, Baird, G, O'Hare, A, Conti-Ramsden, G, Bolton, PF, Hennessy, ER, Ring, SM, Smith, GD, Francks, C , Paracchini, S , Monaco, AP, Fisher, SE, Newbury, DF & the SLI Consortium 2014, ' Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment ' GENES BRAIN AND BEHAVIOR , vol 13, no. 4, pp. 418–429.
Kassaar, O, McMahon, SA, Thompson, R , Botting, CH , Naismith, JH & Stewart, AJ 2014, ' Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an interdomain disulfide bridge: implications for angiogenic regulation ' Blood , vol 123, no. 12, pp. 1948-1955.
Sally Haw, Amanda Amos, Douglas Eadie, John Frank, Laura MacDonald, Anne Marie MacKintosh, Andy MacGregor, Jamie Pearce, Clare Sharp, Martin Stead, Catherine Tisch & van der Sluijs, W 2014, ' Determining the impact of smoking point of sale legislation among youth (Display) study: a protocol for an evaluation of public health policy ' BMC Public Health , vol 14, no. 251.
Esa, R, Leng Ong, A , Humphris, GM & Freeman, R 2014, ' The relationship of dental caries and dental fear in Malaysian adolescents: a latent variable approach ' BMC Oral Health , vol 14, 19.
Popovics, P, Lu, J, Kamil, LN, Morgan, K, Millar, RP, Schmid, R, Blindauer, CA & Stewart, AJ 2014, ' A canonical EF-loop directs Ca 2+ -sensitivity in phospholipase C-η2 ' Journal of Cellular Biochemistry , vol 115, no. 3, pp. 557–565.
Riches, A , Campbell, E , Borger, E & Powis, S 2014, ' Regulation of exosome release from mammary epithelial and breast cancer cells - a new regulatory pathway ' European Journal of Cancer , vol 50, no. 5, pp. 1025-34.
Ba, X, Harrison, EM, Edwards, GF , Holden, MTG , Larsen, AR, Petersen, A, Skov, RL, Peacock, SJ, Parkhill, J, Paterson, GK & Holmes, MA 2014, ' Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec gene ' Journal of Antimicrobial Chemotherapy , vol 69, no. 3, pp. 594-7.
Foster, D , Cox Singh, J , Mohamad, DSA, Krishna, S, Chin, PP & Singh, B 2014, ' Evaluation of three rapid diagnostic tests for the detection of human infections with Plasmodium knowlesi ' Malaria journal , vol 13, 60.
Venturi, E, Galfre, E, O'Brien, F , Pitt, SJ , Bellamy, S, Sessions, RB & Sitsapesan, R 2014, ' FKBP12.6 activates RyR1: investigating the amino acid residues critical for channel modulation ' Biophysical Journal , vol 106, no. 4, pp. 824-833.
Kappagantula, S , Andrews, MR , Cheah, M, Abad-Rodriguez, J, Dotti, CG & Fawcett, JW 2014, ' Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons ' The Journal of Neuroscience , vol 34, no. 7, pp. 2477-2492.
Ploeschner, M, Straka, B , Dholakia, K & Cizmar, T 2014, ' GPU accelerated toolbox for real-time beam-shaping in multimode fibres ' Optics Express , vol 22, no. 3, pp. 2933-2947.
Goltsov, A, Langdon, SP, Goltsov, G , Harrison, DJ & Bown, J 2014, ' Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations ' Frontiers in Oncology , vol 4, 13.
van Hal, SJ, Steen, JA, Espedido, BA, Grimmond, SM, Cooper, MA , Holden, MTG , Bentley, SD, Gosbell, IB & Jensen, SO 2014, ' In vivo evolution of antimicrobial resistance in a series of Staphylococcus aureus patient isolates: the entire picture or a cautionary tale? ' Journal of Antimicrobial Chemotherapy , vol 69, no. 2, pp. 363-7.
Brandler, WM & Paracchini, S 2014, ' The genetic relationship between handedness and neurodevelopmental disorders ' Trends in Molecular Medicine , vol 20, no. 2, pp. 83-90.
Gordon, V , Donnelly, PD & Williams, DJ 2014, ' Relationship between ADHD symptoms and anti-social behaviour in a sample of older youths in adult Scottish prisons ' Personality and Individual Differences , vol 58, pp. 116-121.
Laidlaw, AH , Salisbury, H, Doherty, EM & Wiskin, C 2014, ' National survey of clinical communication assessment in medical education in the United Kingdom (UK) ' BMC Medical Education , vol 14, 10.
Paquete, L, Matias, P, Abbasi, M & Monsanto Pinheiro, M 2014, ' MOSAL: software tools for multiobjective sequence alignment ' Source Code for Biology and Medicine , vol 9, 2.
Grossman, RF, Hsueh, P-R , Gillespie, SH & Blasi, F 2014, ' Community-acquired pneumonia and tuberculosis: differential diagnosis and the use of fluoroquinolones ' International Journal of Infectious Diseases , vol 18, no. 1, pp. 14-21.
Weber, H, Klamer, D, Freudenberg, F, Kittel-Schneider, S, Rivero, O, Scholz, C-J, Volkert, J, Kopf, J, Heupel, J, Herterich, S, Adolfsson, R, Alttoa, A, Post, A, Grussendorf, H, Kramer, A, Gessner, A, Schmidt, B, Hempel, S, Jacob, CP, Sanjuan, J, Molto, MD, Lesch, K-P, Freitag, CM , Kent, L & Reif, A 2014, ' The genetic contribution of the NO system at the glutamatergic post-synapse to schizophrenia: further evidence and meta-analysis ' European Neuropsychopharmacology , vol 24, no. 1, pp. 65-85.