Dr Samantha Pitt
Royal Society of Edinburgh Biomedical Fellow
Samantha Pitt graduated from the University of York in 2002 with a BSc (Hons) degree in Biology. She then went on to complete a PhD in Cellular Physiology at the University of Cambridge graduating in 2006. Following two postdoctoral positions studying mechanisms of ion-channel regulation, one at University College London (Department of Pharmacology) and one at the University of Bristol (Department of Pharmacology) she moved to her current position as a Royal Society of Edinburgh Biomedical Fellow in the School of Medicine, University of St Andrews.
Throughout her career, Samantha’s main focus has been the role of ion-channels in mediating and regulating intracellular Ca2+-signals.
The release of Ca2+ from intracellular stores within the cell is essential for a diverse range of fundamental processes including muscle contraction, fertilisation, cell division and neurotransmitter release. Using electrophysiological approaches Samantha is interested in the study of intracellular ion-channels that are involved in the control and regulation of Ca2+-release in health and disease.
data source: symbiosis
Research Overview from research@st-andrews
In healthy individuals, the controlled release of calcium causes the heart to beat strongly. Calcium is released through specialised gates called ryanodine receptors (RyR2). In patients with heart failure and fatal arrhythmias the release of calcium becomes erratic leading to weakened contraction of heart muscle and cell death. Using a combination of low noise electrophysiological recordings in combination with molecular and biochemical methods my group investigates intracellular calcium dynamics and the molecular function of RyR2 and other ion channels that are present on intracellular organelles. The aim of our research is to try to understand what happens to channel function under pathophysiological conditions.
Recent publications listed in research@st-andrews25 (of 31 published available) for sjp24 (source: University of St Andrews PURE)
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European Neuropsychopharmacology 2019 vol.29 pp.1194-1195
BioMetals 2019 vol.32 pp.123-138
Arteriosclerosis, Thrombosis, and Vascular Biology 2018 vol.38 pp.1258-1270
Metallomics 2018 vol.10 pp.1180-1190
Molecular and Cellular Endocrinology 2017 vol.446 pp.12-20
Molecular and Cellular Biochemistry 2017 vol.436 pp.49-58
Journal of Biological Chemistry 2017 vol.292 pp.13361-13373
Current Vascular Pharmacology 2017 vol.15 pp.491-500
Scientific Reports 2017 vol.7
Nitric Oxide 2016 vol.54 pp.51-59
The Journal of Physiology 2016 vol.594 pp.4171-4179
Journal of Biological Chemistry 2016 vol.291 pp.4267
Biochemical Society Transactions 2015 vol.43 pp.359-363
Journal of Biological Chemistry 2015 vol.290 pp.17599-17610
Channels 2015 vol.9 pp.223-225
Molecular and Cellular Endocrinology 2014 vol.388 pp.58-68
Biophysical Journal 2014 vol.106 pp.824-833
Science Signaling 2014 vol.7
Biophysical Journal 2014 vol.106 pp.642A-642A
PflÃ¼gers Archiv: European Journal of Physiology 2013 vol.465 pp.1135-1148
PLoS One 2012 vol.7
Cardiovascular Therapeutics 2012 vol.30 pp.109-16
Journal of Membrane Biology 2011 vol.240 pp.21-33