Dr Samantha Pitt

Dr Samantha Pitt
Royal Society of Edinburgh Biomedical Fellow

Samantha Pitt graduated from the University of York in 2002 with a BSc (Hons) degree in Biology. She then went on to complete a PhD in Cellular Physiology at the University of Cambridge graduating in 2006. Following two postdoctoral positions studying mechanisms of ion-channel regulation, one at University College London (Department of Pharmacology) and one at the University of Bristol (Department of Pharmacology) she moved to her current position as a Royal Society of Edinburgh Biomedical Fellow in the School of Medicine, University of St Andrews.

Throughout her career, Samantha’s main focus has been the role of ion-channels in mediating and regulating intracellular Ca2+-signals.

The release of Ca2+ from intracellular stores within the cell is essential for a diverse range of fundamental processes including muscle contraction, fertilisation, cell division and neurotransmitter release. Using electrophysiological approaches Samantha is interested in the study of intracellular ion-channels that are involved in the control and regulation of Ca2+-release in health and disease.


data source: symbiosis

Research Overview from research@st-andrews

In healthy individuals, the controlled release of calcium causes the heart to beat strongly.  Calcium is released through specialised gates called ryanodine receptors (RyR2). In patients with heart failure and fatal arrhythmias the release of calcium becomes erratic leading to weakened contraction of heart muscle and cell death. Using a combination of low noise electrophysiological recordings in combination with molecular and biochemical methods my group investigates intracellular calcium dynamics and the molecular function of RyR2 and other ion channels that are present on intracellular organelles. The aim of our research is to try to understand what happens to channel function under pathophysiological conditions.

Recent publications listed in research@st-andrews
25 (of 31 published available) for sjp24 (source: University of St Andrews PURE)
Please click title of any item for full details

FUNCTIONAL CHARACTERIZATION OF ATP2C2, A RISK FACTOR FOR LANGUAGE DISORDERS Angela Martinelli, Irene Feliciotti, Samantha J. Pitt, Silvia Paracchini
European Neuropsychopharmacology 2019 vol.29 pp.1194-1195
Plasma non-esterified fatty acids contribute to increased coagulability in type-2 diabetes through altered plasma zinc speciation Fladia A. Phoenix, Siavash Khazaipoul, Ruitao Yu, Fanuel Lampiao, Fiona Stefanowicz, Claudia A. Blindauer, Samantha J. Pitt, Terry K Smith, Ramzi A. Ajjan, Alan J. Stewart
biorxiv 2019 
Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes Fiona Stefanowicz, Samantha J. Pitt, Ramzi A. Ajjan, Alan J. Stewart
BioMetals 2019 vol.32 pp.123-138
Glycosaminoglycan neutralization in coagulation control Samantha J. Pitt, Alan J. Stewart
Arteriosclerosis, Thrombosis, and Vascular Biology 2018 vol.38 pp.1258-1270
Influence of zinc on glycosaminoglycan neutralisation during coagulation Samantha J. Pitt, Alan J. Stewart
Metallomics 2018 vol.10 pp.1180-1190
17ß-Estradiol protects against the effects of a high fat diet on cardiac glucose, lipid and nitric oxide metabolism in rats Sonja Zafirovic, Milan Obradovic, Emina Sudar-Milovanovic, Alexsandra Jovanovic, Julijana Stanimirovic, Alan J. Stewart, Samantha J. Pitt, Esma R. Isenovic
Molecular and Cellular Endocrinology 2017 vol.446 pp.12-20
Changes in cardiac Na+/K+-ATPase expression and activity in female rats fed a high fat diet Aleksandra Jovanovic, Milan Obradovic, Emina Sudar-Milovanovic, Alan J. Stewart, Samantha J. Pitt, Dragan Alvantic, Ema Aleksic, Esma R. Isenovic
Molecular and Cellular Biochemistry 2017 vol.436 pp.49-58
Dysregulated Zn2+ homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca2+ leakage Angela Karumbi, Connor McIntyre, Wojciech Bal, Miyuki Nishi, Hiroshi Takeshima, Alan J. Stewart, Samantha J. Pitt
Journal of Biological Chemistry 2017 vol.292 pp.13361-13373
Influence of a high-fat diet on cardiac iNOS in female rats Aleksandra Jovanovic, Emina Sudar-Milovanovic, Milan Obradovic, Samantha J. Pitt, Alan J. Stewart, Sonja Zafirovic, Julijana Stanimirovic, Djordje Radak, Esma R. Isenovic
Current Vascular Pharmacology 2017 vol.15 pp.491-500
Modulation of the Neisseria gonorrhoeae drug efflux conduit MtrE Giulia Tamburrino, Salome Llabres, Owen Vickery, Samantha J. Pitt, Ulrich Zachariae
Scientific Reports 2017 vol.7 
A high fat diet induces sex-specific differences in hepatic lipid metabolism and nitrite/nitrate in rats Julijana Stanimirovic, Milan M Obradovic, Aleksandra Jovanovic, Emina Sudar-Milovanovic, Sonja Zafirovic, Samantha J. Pitt, Alan J. Stewart, Esma R Isenovic
Nitric Oxide 2016 vol.54 pp.51-59
Exploring the biophysical evidence that mammalian two pore channels are NAADP-activated calcium-permeable channels Samantha J. Pitt, Rebecca Sitsapesan
The Journal of Physiology 2016 vol.594 pp.4171-4179
Response to Qian and Colvin Jason Woodier, Richard D Rainbow, Alan J. Stewart, Samantha J. Pitt
Journal of Biological Chemistry 2016 vol.291 pp.4267
Examining a new role for zinc in regulating calcium release in cardiac muscle Samantha J. Pitt, Alan J. Stewart
Biochemical Society Transactions 2015 vol.43 pp.359-363
Intracellular zinc modulates cardiac ryanodine receptor-mediated calcium release Jason Woodier, Richard Rainbow, Alan J. Stewart, Samantha J. Pitt
Journal of Biological Chemistry 2015 vol.290 pp.17599-17610
Zinc controls RyR2 activity during excitation-contraction coupling Alan J. Stewart, Samantha J. Pitt
Channels 2015 vol.9 pp.223-225
In vivo effects of 17β-estradiol on cardiac Na+/K+-ATPase expression and activity in rat heart Milan Obradovic, Alan J. Stewart, Samantha J. Pitt, Milica Labudovic-Borovic, Emina Sudar, Voin Petrovic, Sonja Zafirovic, Vera Maravic-Stojkovic, Vesna Vasic, Esma R Isenovic
Molecular and Cellular Endocrinology 2014 vol.388 pp.58-68
FKBP12.6 activates RyR1 Elisa Venturi, Elena Galfre, Fiona O'Brien, Samantha J. Pitt, Stuart Bellamy, Richard B. Sessions, Rebecca Sitsapesan
Biophysical Journal 2014 vol.106 pp.824-833
Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+ Samantha J. Pitt, Andy K M Lam, Katja Rietdorf, Antony Galione, Rebecca Sitsapesan
Science Signaling 2014 vol.7 
TPC1 is a proton permeable channel that can be independently activated by cytosolic calcium or NAADP Samantha J. Pitt, Andy Lam, Antony Galione, Rebecca Sitsapesan
Biophysical Journal 2014 vol.106 pp.642A-642A
TRIC-B channels display labile gating Elisa Venturi, Antoni Matyjaszkiewicz, Samantha J. Pitt, Krasimira Tsaneva-Atanasova, Miyuki Nishi, Daiju Yamazaki, Hiroshi Takeshima, Rebecca Sitsapesan
Pflügers Archiv: European Journal of Physiology 2013 vol.465 pp.1135-1148
FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6 Elena Galfre, Samantha J. Pitt, Elisa Venturi, Mano Sitsapesan, Nathan R Zaccai, Krasimira Tsaneva-Atanasova, Stephen O'Neill, Rebecca Sitsapesan
PLoS One 2012 vol.7 
From eggs to hearts: what is the link between cyclic ADP-ribose and ryanodine receptors? Elisa Venturi, Samantha J. Pitt, Elena Galfre, Rebecca Sitsapesan
Cardiovascular Therapeutics 2012 vol.30 pp.109-16
Ca2+-dependent phosphorylation of RyR2 can uncouple channel gating from direct cytosolic Ca2+ regulation Simon Carter, Samantha J. Pitt, John Colyer, Rebecca Sitsapesan
Journal of Membrane Biology 2011 vol.240 pp.21-33