Dr Simon Powis
I graduated from the University of Glasgow with a BSc (Hons) in Immunology in 1986, and then undertook PhD studies at the University of Cambridge, based at the Babraham Research Institute, graduating 1990. Two postdoctoral positions followed at Babraham, followed by a move the University of Dundee where I held a Wellcome Trust Career Development Award (1995-1999) and then an MRC Senior Fellowship from 1999-2004. In 2005, I moved to my current post in the School of Medicine at the University of St Andrews.
Throughout my career, my main research focus has been a group of molecules in the immune system called the Major Histocompatibility Complex (MHC) class I molecules. These proteins are involved in protection against viral infections, cancer neogenesis and transplant rejection. I have been closely involved in characterizing how these MHC class I molecules assemble inside cells, where they undergo a complex series of quality control tests before being delivered to the cell surface for scrutiny by T lymphocytes and Natural Killer cells.
I am also studying one particular MHC class I molecule termed HLA-B27, which is closely involved in the development of a type of inflammatory arthritis of the spine called ankylosing spondylitis. If we can understand the role HLA-B27 plays, we will be able to develop novel therapeutic strategies.
With regard to teaching at the School, I deliver a series of lectures to medical students describing how the immune system works and what can happen when it goes wrong.
- Postgraduate ProDean – oversight at faculty-level of postgraduate student business
- Module Controller – MD5102, a series of research-focused seminars for the MRes degree.
- Centrifuge Curator – fixing them when they go wrong.
Research Overview from research@st-andrewsThe immune system relies on the ability to detect when cells are virally infected, or potentially tumorigenic, and to specifically eliminate these cells. This is achieved by the actions of Major Histocompatibility Complex (MHC) class I molecules, which bind small peptides from the proteolytic turnover of proteins in the cytoplasm, and present these peptides on the cell surface to T lymphocytes. Detection of viral, or non-self, peptides can stimulate the generation of potent anti-viral cytotoxic T lymphocyte responses.
Recent publications listed in research@st-andrews25 (of 69 published available) for sjp10 (source: University of St Andrews PURE)
Please click title of any item for full details
Frontiers in Immunology 2019 vol.10
Optics Express 2019 vol.27 pp.13706-13720
Scientific Reports 2019 vol.9
Annals of the Rheumatic Diseases 2019 vol.78 pp.74â82
Nature Communications 2018 vol.9
Scientific Reports 2017 vol.7
Nature Cell Biology 2017 vol.19 pp.864-872
Scientific Reports 2017 vol.7
Arthritis & Rheumatology 2017 vol.69 pp.610-621
Brain, Behavior, and Immunity 2017 vol.60
Journal of Biological Chemistry 2017 vol.292 pp.17084-17092
Arthritis & Rheumatology 2016 vol.68 pp.1057-1059
Journal of Virology 2015 vol.89 pp.4770-4785
Biomedical Optics Express 2015 vol.6 pp.1512-1519
Bladder 2015 vol.2
Nano Letters 2015 vol.15 pp.5674-5652
PLoS One 2015 vol.10
Arthritis & Rheumatology 2014 vol.66 pp.2976-2988
European Journal of Cancer 2014 vol.50 pp.1025-34
Experimental Cell Research 2013 vol.319 pp.1706-13
Clinical and Experimental Rheumatology 2012 vol.30 pp.603-603
Clinical and Experimental Rheumatology 2012 vol.30 pp.637-637
Immunology 2012 vol.135 pp.133-139
Immunology 2012 vol.136 pp.192-197