Dr Ruth Bowness

Dr Ruth Bowness
Postdoctoral Research Assistant



I graduated with a BSc in Mathematics from the University of St Andrews in 2005, and after Masters courses in Mathematics and Numerical Computing from the University of Cambridge and the University of Manchester, I returned to St Andrews to complete a PhD in Applied Maths. During my PhD I worked in the Solar MHD group, my project involved numerically solving the Magnetohydrodynamic (MHD) equations in order to model solar phenomena.

I joined the St Andrews Medical School in September 2012 to work with Professor Stephen Gillespie’s research group on the PreDiCT-TB work programme. Working also with Dr Duncan Mackay from the St Andrews Mathematics and Statistics department, we aim to separate populations of different cell states of Mycobacterium tuberculosis and model their response to tuberculosis treatment in clinical trials. Ultimately we hope to develop an appropriate mathematical framework within which data generated from experiments and clinical trials can be integrated. In this way we will attempt to form template models that could help to form treatment plans and aid future drug development.

data source: symbiosis

Research Overview from research@st-andrews

My research interests lie in developing mechanistic models to describe complex biomedical systems.  Mechanistic models can summarise current knowledge and their development can lead to greater understanding of the biological system.  These models can also be used to highlight gaps in current knowledge and identify tractable clinically important questions.

 


source: research@st-andrews
Recent publications listed in research@st-andrews
Bowness, R 2016, Systems medicine and infection. in U Schmitz & O Wolkenhauer (eds), Systems Medicine. Methods in Molecular Biology, vol. 1386, Springer, pp. 107-118. DOI: 10.1007/978-1-4939-3283-2_7
Donald, I, Meyer, K, Gillespie, SH, Bowness, R & Brengman, J 2015, Project Sanitarium: gaming TB - A serious game for a serious problem. in 7th International Conference on Games and Virtual Worlds for Serious Applications, VS-Games 2015., 7295782, IEEE, Seventh International Conference on Virtual Worlds and Games for Serious Applications: VS-Games 2015, University of Skövde, Sweden, 16-18 September. DOI: 10.1109/VS-GAMES.2015.7295782
Bowness, R, Boeree, MJ, Aarnoutse, R, Dawson, R, Diacon, A, Mangu, C, Heinrich, N, Ntinginya, NE, Kohlenberg, A, Mtafya, B, Phillips, PPJ, Rachow, A, Plemper van Balen, G & Gillespie, SH 2015, 'The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations' Journal of Antimicrobial Chemotherapy, vol 70, no. 2, pp. 448-455. DOI: 10.1093/jac/dku415