Dr Kerry Pettigrew

Dr Kerry Pettigrew
Post Doctoral Researcher

I graduated in Biomedical Sciences from University of Ulster in 2003, and obtained my PhD from Queens University Belfast in 2007; my project entailed case-control candidate gene studies to identify genetic variants influencing susceptibility to nephropathy in type 1 diabetes. Since 2007, I have conducted research on alveolar cell damage and growth (University of Birmingham), DNA methylation in acute myeloid leukaemia (Queens University Belfast) and identification of genetic variants predisposing to prostate cancer (National Cancer Institute, US), hypertension (University of Glasgow) and cognitive traits in childhood (University of St Andrews). I also spent some time as Senior Scientific Officer at the Cancer Research UK Genome Variation Laboratory Service (Leeds).

In April 2015 I joined the Holden group to perform next-generation sequencing of bacterial isolates from hospital-acquired infections as part of the Molecular Epidemiology workstream of the Scottish Healthcare Associated Infection Prevention Institute (SHAIPI) consortium.

data source: symbiosis

Research Overview from research@st-andrews

Recent publications listed in research@st-andrews
Harkins, CP, Pettigrew, KA, Oravcova, K, Gardner, J, Hearn, R, Rice, D, Mather, AE, Parkhill, J, Brown, SJ, Proby, CM & Holden, MT 2017, 'The genetic diversity of Staphylococcus aureus colonisation in atopic eczema disease flare' Journal of Investigative Dermatology, vol. 137, no. 10, pp. S258-S258.
Hsu, L-Y, Holden, MTG, Koh, TH, Pettigrew, KA, Cao, D, Hon, PY, Sergio, DM, Pena, E & Ogden, BE 2017, 'ST3268: a geographically widespread primate MRSA clone' Journal of Antimicrobial Chemotherapy, vol. 72, no. 8, pp. 2401-2403. https://doi.org/10.1093/jac/dkx120
Chow, A, Lim, VW, Khan, A, Pettigrew, K, Lye, DCB, Kanagasabai, K, Phua, K, Krishnan, P, Ang, B, Marimuthu, K, Hon, P-Y, Koh, J, Leong, I, Parkhill, J, Hsu, L-Y & Holden, MTG 2017, 'MRSA transmission dynamics among interconnected acute, intermediate-term, and long-term healthcare facilities in Singapore' Clinical Infectious Diseases, vol. 64, no. suppl_2, pp. S76-S81. https://doi.org/10.1093/cid/cix072
Pettigrew, KA, Frinton, E, Nudel, R, Chan, MTM, Thompson, P, Hayiou-Thomas, ME, Talcott, JB, Stein, J, Monaco, AP, Hulme, C, Snowling, MJ, Newbury, DF & Paracchini, S 2016, 'Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes' Journal of Neurodevelopmental Disorders, vol. 8, 24. https://doi.org/10.1186/s11689-016-9157-6
Shore, RJ, Covill, L, Pettigrew, KA, Brandler, WA, Diaz Vazquez, R, Xu, Y, Tello, J, Talcott, JB, Newbury, DF, Stein, J, Monaco, AP & Paracchini, S 2016, 'The handedness-associated PCSK6 locus spans an intronic promoter regulating novel transcripts' Human Molecular Genetics, vol. 25, no. 9, pp. 1771-1779. https://doi.org/10.1093/hmg/ddw047
Pettigrew, KA, Reeves, E, Leavett, R, Hayiou-Thomas, ME, Sharma, A, Simpson, NH, Martinelli, A, Thompson, P, Hulme, C, Snowling, MJ, Newbury, DF & Paracchini, S 2015, 'Copy number variation screen identifies a rare de novo deletion at chromosome 15q13.1-13.3 in a child with language impairment' PLoS One, vol. 10, no. 8, e0134997. https://doi.org/10.1371/journal.pone.0134997
Pettigrew, KA, Fajutrao Valles, SF, Moll, K, Northstone, K, Ring, S, Pennell, C, Wang, C, Leavett, R, Hayiou-Thomas, ME, Thompson, P, Simpson, NH, Fisher, SE, Whitehouse, AJO, Snowling, MJ, Newbury, DF, Paracchini, S & SLI Consortium 2015, 'Lack of replication for the myosin-18B association with mathematical ability in independent cohorts' Genes, Brain and Behavior, vol. 14, no. 4, pp. 369-376. https://doi.org/10.1111/gbb.12213
Parikh, H, Wang, Z, Pettigrew, KA, Jia, J, Daugherty, S, Yeager, M, Jacobs, KB, Hutchinson, A, Burdett, L, Cullen, M, Qi, L, Boland, J, Collins, I, Albert, TJ, Vatten, LJ, Hveem, K, Njolstad, I, Cancel-Tassin, G, Cussenot, O, Valeri, A, Virtamo, J, Thun, MJ, Feigelson, HS, Diver, WR, Chatterjee, N, Thomas, G, Albanes, D, Chanock, SJ, Hunter, DJ, Hoover, R, Hayes, RB, Berndt, SI, Sampson, J & Amundadottir, L 2011, 'Fine mapping the KLK3 locus on chromosome 19q13.33 associated with prostate cancer susceptibility and PSA levels' Human Genetics, vol. 129, no. 6, pp. 675-685. https://doi.org/10.1007/s00439-011-0953-5
McKnight, AJ, Pettigrew, KA, Patterson, CC, Kilner, J, Sadlier, DM, Maxwell, AP & Warren 3 UK GoKinD Study Grp 2010, 'Investigation of the association of BMP gene variants with nephropathy in Type 1 diabetes mellitus' Diabetic Medicine, vol. 27, no. 6, pp. 624-630. https://doi.org/10.1111/j.1464-5491.2010.02976.x
McKnight, AJ, Patterson, CC, Pettigrew, KA, Savage, DA, Kilner, J, Murphy, M, Sadlier, D, Maxwell, AP & Warren 3 UK Genetics Kidneys Diab 2010, 'A GREM1 Gene Variant Associates with Diabetic Nephropathy' Journal of the American Society of Nephrology, vol. 21, no. 5, pp. 773-781. https://doi.org/10.1681/ASN.2009070773
McKnight, AJ, Woodman, AM, Parkkonen, M, Patterson, CC, Savage, DA, Forsblom, C, Pettigrew, KA, Sadlier, D, Groop, PH, Maxwell, AP & Warren 3 UK GoKinD Study Grp 2009, 'Investigation of DNA polymorphisms in SMAD genes for genetic predisposition to diabetic nephropathy in patients with type 1 diabetes mellitus' Diabetologia, vol. 52, no. 5, pp. 844-849. https://doi.org/10.1007/s00125-009-1281-3
Pettigrew, KA, McKnight, AJ, Martin, RJ, Patterson, CC, Kilner, J, Sadlier, D, Maxwell, AP, Savage, DA & Warren 3 K GoKinD Study Grp 2008, 'No support for association of protein kinase C, beta 1 (PRKCB1) gene promoter polymorphisms c.-1504C > T and c.-546C > G with diabetic nephropathy in Type 1 diabetes' Diabetic Medicine, vol. 25, no. 9, pp. 1127-1129. https://doi.org/10.1111/j.1464-5491.2008.02540.x
Mckeown, ST, O'Kane, CM, Perkins, GD, Pettigrew, K, Gao, F, Thickett, DR & Mcauley, DF 2007, 'Salbutamol drives upregulated MMP-9 activity in the alveolar space in acute respiratory distress syndrome' Thorax, vol. 62, pp. A63-A63.
Perkins, G, Pettigrew, K, Rathinam, S, Rajesh, P, Gao, F, Hughes, S, Bassford, C, Stewart, PM & Thickett, D 2007, 'Aberrant local steroid metabolism and its modulation by intravenous salbutamol in patients with acute respiratory distress syndrome' Thorax, vol. 62, pp. A113-A114.