Prof John Zajicek

Prof John Zajicek
Chair in Medicine



data source: symbiosis

Research Overview from research@st-andrews

Professor John Zajicek trained in Medicine at Cambridge and St Mary’s Hospital in London. He completed a PhD in cell biology in Cambridge, moved to Plymouth in 1995 as a Consultant Neurologist, and took up the Chair of Clinical Neuroscience at Plymouth University. In Plymouth he was Director of the Peninsula Clinical Trials Unit, and Chair of the UK NIHR Nervous System Disorders Specialty Group. He has recently moved to the University of St Andrews, where he is Professor of Medicine. Zajicek has served on the UK MRC Neuroscience and Mental Health Board and the MRC Methodology Panel. He is particularly interested in the way we do trials for neurodegenerative diseases, has been Chief Investigator in several large multicentre randomized controlled trials, including the investigation of cannabinoid use to slow neurodegeneration. He has authored many papers on cannabinoids, multiple sclerosis and the methodology of clinical trials in neurodegeneration, including Alzheimer’s and Parkinson’s diseases.


source: research@st-andrews
Recent publications listed in research@st-andrews
Cruz, PMR, Matthews, L, Boggild, M, Cavey, A, Constantinescu, CS, Evangelou, N, Giovannoni, G, Gray, O, Hawkins, S, Nicholas, R, Oppenheimer, M, Robertson, N, Zajicek, J, Rothwell, PM & Palace, J 2016, 'Time-and region-specific season of birth effects in multiple sclerosis in the United Kingdom' JAMA Neurology, vol 73, no. 8, pp. 954-960. DOI: 10.1001/jamaneurol.2016.1463
O'Connor, P, Comi, G, Freedman, MS, Miller, AE, Kappos, L, Bouchard, J-P, Lebrun-Frenay, C, Mares, J, Benamor, M, Thangavelu, K, Liang, J, Truffinet, P, Lawson, VJ, Wolinsky, JS, Teriflunomide Multiple Sclerosis Oral (TEMSO) Trial Group and the MRI-AC in Houston, Texas & Zajicek, JP 2016, 'Long-term safety and efficacy of teriflunomide: nine-year follow-up of the randomized TEMSO study' Neurology, vol 86, no. 10, pp. 920-930. DOI: 10.1212/WNL.0000000000002441
Scolding, N, Barnes, D, Cader, S, Chataway, J, Chaudhuri, A, Coles, A, Giovannoni, G, Miller, D, Rashid, W, Schmierer, K, Shehu, A, Silber, E, Young, C & Zajicek, J 2015, 'Association of British Neurologists: revised (2015) guidelines for prescribing disease-modifying treatments in multiple sclerosis' Practical Neurology, vol 15, no. 4, pp. 273-279. DOI: 10.1136/practneurol-2015-001139
McGhee, DJM, Ritchie, CW, Thompson, PA, Wright, DE, Zajicek, JP & Counsell, CE 2014, 'A systematic review of biomarkers for disease progression in Alzheimer's disease' PLoS One, vol 9, no. 2, e88854. DOI: 10.1371/journal.pone.0088854
Hilton, D, Stephens, M, Kirk, L, Edwards, P, Potter, R, Zajicek, J, Broughton, E, Hagan, H & Carroll, C 2014, 'Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson's disease' Acta neuropathologica, vol 127, no. 2, pp. 235-41. DOI: 10.1007/s00401-013-1214-6
Beecham, AH, Patsopoulos, NA, Xifara, DK, Davis, MF, Kemppinen, A, Cotsapas, C, Shah, TS, Spencer, C, Booth, D, Goris, A, Oturai, A, Saarela, J, Fontaine, B, Hemmer, B, Martin, C, Zipp, F, D'Alfonso, S, Martinelli-Boneschi, F, Taylor, B, Harbo, HF, Kockum, I, Hillert, J, Olsson, T, Ban, M, Oksenberg, JR, Hintzen, R, Barcellos, LF, Agliardi, C, Alfredsson, L, Alizadeh, M, Anderson, C, Andrews, R, Søndergaard, HB, Baker, A, Band, G, Baranzini, SE, Barizzone, N, Barrett, J, Bellenguez, C, Bergamaschi, L, Bernardinelli, L, Berthele, A, Biberacher, V, Binder, TMC, Blackburn, H, Bomfim, IL, Brambilla, P, Broadley, S, Brochet, B, Brundin, L, Buck, D, Butzkueven, H, Caillier, SJ, Camu, W, Carpentier, W, Cavalla, P, Celius, EG, Coman, I, Comi, G, Corrado, L, Cosemans, L, Cournu-Rebeix, I, Cree, BAC, Cusi, D, Damotte, V, Defer, G, Delgado, SR, Deloukas, P, di Sapio, A, Dilthey, AT, Donnelly, P, Dubois, B, Duddy, M, Edkins, S, Elovaara, I, Esposito, F, Evangelou, N, Fiddes, B, Field, J, Franke, A, Freeman, C, Frohlich, IY, Galimberti, D, Gieger, C, Gourraud, P-A, Graetz, C, Graham, A, Grummel, V, Guaschino, C, Hadjixenofontos, A, Hakonarson, H, Halfpenny, C, Hall, G, Hall, P, Hamsten, A, Harley, J, Harrower, T, Hawkins, C, Hellenthal, G, Hillier, C, Hobart, J, Hoshi, M, Hunt, SE, Jagodic, M, Jelčić, I, Jochim, A, Kendall, B, Kermode, A, Kilpatrick, T, Koivisto, K, Konidari, I, Korn, T, Kronsbein, H, Langford, C, Larsson, M, Lathrop, M, Lebrun-Frenay, C, Lechner-Scott, J, Lee, MH, Leone, MA, Leppä, V, Liberatore, G, Lie, BA, Lill, CM, Lindén, M, Link, J, Luessi, F, Lycke, J, Macciardi, F, Männistö, S, Manrique, CP, Martin, R, Martinelli, V, Mason, D, Mazibrada, G, McCabe, C, Mero, I-L, Mescheriakova, J, Moutsianas, L, Myhr, K-M, Nagels, G, Nicholas, R, Nilsson, P, Piehl, F, Pirinen, M, Price, SE, Quach, H, Reunanen, M, Robberecht, W, Robertson, NP, Rodegher, M, Rog, D, Salvetti, M, Schnetz-Boutaud, NC, Sellebjerg, F, Selter, RC, Schaefer, C, Shaunak, S, Shen, L, Shields, S, Siffrin, V, Slee, M, Sorensen, PS, Sorosina, M, Sospedra, M, Spurkland, A, Strange, A, Sundqvist, E, Thijs, V, Thorpe, J, Ticca, A, Tienari, P, van Duijn, C, Visser, EM, Vucic, S, Westerlind, H, Wiley, JS, Wilkins, A, Wilson, JF, Winkelmann, J, Zajicek, J, Zindler, E, Haines, JL, Pericak-Vance, MA, Ivinson, AJ, Stewart, G, Hafler, D, Hauser, SL, Compston, A, McVean, G, De Jager, P, Sawcer, SJ, McCauley, JL & International Multiple Sclerosis Genetics Consortium (IMSGC) 2013, 'Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis' Nature Genetics, vol 45, no. 11, pp. 1353-60. DOI: 10.1038/ng.2770
Hobart, J, Cano, S, Baron, R, Thompson, A, Schwid, S, Zajicek, J & Andrich, D 2013, 'Achieving valid patient-reported outcomes measurement: a lesson from fatigue in multiple sclerosis' Multiple Sclerosis Journal, vol 19, no. 13, pp. 1773-83. DOI: 10.1177/1352458513483378
Zajicek, J, Ball, S, Wright, D, Vickery, J, Nunn, A, Miller, D, Gomez Cano, M, McManus, D, Mallik, S, Hobart, J & CUPID investigator group 2013, 'Effect of dronabinol on progression in progressive multiple sclerosis (CUPID): a randomised, placebo-controlled trial' Lancet Neurology, vol 12, no. 9, pp. 857-65. DOI: 10.1016/S1474-4422(13)70159-5
Mechelli, R, Umeton, R, Policano, C, Annibali, V, Coarelli, G, Ricigliano, VAG, Vittori, D, Fornasiero, A, Buscarinu, MC, International Multiple Sclerosis Genetics Consortium (IMSGC), Wellcome Trust Case Control Consortium, 2 (WTCCC2), Romano, S, Salvetti, M & Ristori, G 2013, 'A "candidate-interactome" aggregate analysis of genome-wide association data in multiple sclerosis' PLoS One, vol 8, no. 5, e63300. DOI: 10.1371/journal.pone.0063300
McGhee, DJM, Royle, PL, Thompson, PA, Wright, DE, Zajicek, JP & Counsell, CE 2013, 'A systematic review of biomarkers for disease progression in Parkinson's disease' BMC Neurology, vol 13, 35. DOI: 10.1186/1471-2377-13-35
Posner, HB, Cano, S, Carrillo, MC, Selnes, O, Stern, Y, Thomas, RG, Zajicek, J, Hobart, J & Alzheimer's Disease Neuroimaging Initiative 2013, 'Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: a new approach' Alzheimer's and Dementia, vol 9, no. 1 Suppl, pp. S56-60. DOI: 10.1016/j.jalz.2012.10.008
Hobart, J, Cano, S, Posner, H, Selnes, O, Stern, Y, Thomas, R, Zajicek, J & Alzheimer's Disease Neuroimaging Initiative 2013, 'Putting the Alzheimer's cognitive test to the test II: Rasch Measurement Theory' Alzheimer's and Dementia, vol 9, no. 1 Suppl, pp. S10-20. DOI: 10.1016/j.jalz.2012.08.006
Hobart, J, Cano, S, Posner, H, Selnes, O, Stern, Y, Thomas, R, Zajicek, J & Alzheimer's Disease Neuroimaging Initiative 2013, 'Putting the Alzheimer's cognitive test to the test I: traditional psychometric methods' Alzheimer's and Dementia, vol 9, no. 1 Suppl, pp. S4-9. DOI: 10.1016/j.jalz.2012.08.005
Escudero, J, Ifeachor, E, Zajicek, JP, Green, C, Shearer, J, Pearson, S & Alzheimer's Disease Neuroimaging Initiative 2013, 'Machine learning-based method for personalized and cost-effective detection of Alzheimer's disease' IEEE Transactions on Biomedical Engineering, vol 60, no. 1, pp. 164-8. DOI: 10.1109/TBME.2012.2212278