Dr Javier Tello

Dr Javier Tello
Lecturer in Pharmacology



data source: symbiosis

Research Overview from research@st-andrews

My research interfaces cellular biology, pharmacology, and reproductive physiology, with the goal of understanding and treating fertility disorders emanating from the brain and pituitary. Neuropeptides play a critical role in a number of homeostatic processes, including metabolism, body composition, sleep/wake cycles, response to stress and ageing. However, irregular activity in any one of these processes can usurp normal reproductive function and lead to infertility.

The main goal of my research is to understand how neural networks are modulated by these peptides in the brain relevant to normal development and ageing, and to understand the molecular basis of neuropeptide signalling in both fertile and disease models.

My lab uses transgenic animals, brain slice physiology and molecular approaches to elucidate the cellular events involved with neuroendocrine responses in the hypothalamus and amygdala. We also employ state-of-the art viral vector transduction techniques (e.g. chemogenetics and optogenetics) combined with live calcium imaging and multi-labelling techniques to answer questions related to the neural circuitry underlying these physiological effects. Use of these combined techniques build a powerful arsenal for answering questions related to puberty and fertility.

Current research funding is provided by:

The Northwood Charitable Trust

The Society for Endocrinology - Early Career Grant

The Society for Endocrinology - Equipment Grant

http://www.endocrinology.org/

The British Society for Neuroendocrinology - Project Support Grant

Medical Research Scotland - Summer Studentship


source: research@st-andrews
Recent publications listed in research@st-andrews
Shore, RJ, Covill, L, Pettigrew, KA, Brandler, WA, Diaz Vazquez, R, Xu, Y, Tello, J, Talcott, JB, Newbury, DF, Stein, J, Monaco, AP & Paracchini, S 2016, 'The handedness-associated PCSK6 locus spans an intronic promoter regulating novel transcripts' Human Molecular Genetics, vol 25, no. 9, pp. 1771-1779. DOI: 10.1093/hmg/ddw047
Young, J, George, J, Tello, J, Francou, B, Bouligand, J, Guiochon-Mantel, A, Brailly-Tabard, S, Anderson, R & Millar, R 2013, 'Kisspeptin restores pulsatile LH secretion in patients with neurokinin B signaling deficiencies: physiological, pathophysiological and therapeutic implications' Neuroendocrinology, vol 97, no. 2, pp. 193-202. DOI: 10.1159/000336376
Sonigo, C, Bouilly, J, Carre, N, Tolle, V, Caraty, A, Tello, J, Simony-Conesa, F-J, Millar, R, Young, J & Binart, N 2012, 'Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration' The Journal of Clinical Investigation, vol 122, no. 10, pp. 3791-3795. DOI: 10.1172/JCI63937
Topaloglu, AK, Tello, J, Kotan, D, Ozbek, M, Yilmaz, B, Erdogan, S, Gurbuz, F, Temiz, F, Millar, R & Yuksel, B 2012, 'Inactivating KISS1 mutation and hypogonadotropic hypogonadism' New England Journal of Medicine, vol 366, no. 7, pp. 629-635. DOI: 10.1056/NEJMoa1111184
Bouligand, J, Ghervan, C, Tello, J, Brailly-Tabard, S, Salenave, S, Chanson, P, Lombes, M, Millar, R & Guiochon-Mantel, A 2009, 'Isolated familial hypogonadotropic hypogonadism and a GNRH1 mutation' New England Journal of Medicine, vol 360, no. 26, pp. 2742-2748. DOI: 10.1056/NEJMoa0900136
Holland, LZ, Albalat, R, Azumi, K, Benito-Gutierrez, E, Blow, MJ, Bronner-Fraser, M, Brunet, F, Butts, T, Candiani, S, Dishaw, LJ, Ferrier, DEK, Garcia-Fernandez, J, Gibson-Brown, JJ, Gissi, C, Godzik, A, Hallbook, F, Hirose, D, Hosomichi, K, Ikuta, T, Inoko, H, Kasahara, M, Kasamatsu, J, Kawashima, T, Kimura, A, Kobayashi, M, Kozmik, Z, Kubokawa, K, Laudet, V, Litman, GW, McHardy, AC, Meulemans, D, Nonaka, M, Olinski, RP, Pancer, Z, Pennacchio, LA, Pestarino, M, Rast, JP, Rigoutsos, I, Robinson-Rechavi, M, Roch, G, Saiga, H, Sasakura, Y, Satake, M, Satou, Y, Schubert, M, Sherwood, N, Shiina, T, Takatori, N, Tello, J, Vopalensky, P, Wada, S, Xu, A, Ye, Y, Yoshida, K, Yoshizaki, F, Yu, J-K, Zhang, Q, Zmasek, CM, de Jong, PJ, Osoegawa, K, Putnam, NH, Rokhsar, DS, Satoh, N & Holland, PWH 2008, 'The amphioxus genome illuminates vertebrate origins and cephalochordate biology' Genome Research, vol 18, pp. 1100-1111. DOI: 10.1101/gr.073676.107
Adams, B, Tello, J, Erchegyi, J, Warby, C, Hong, D, Akinsanya, K, Mackie, G, Vale, W, Rivier, J & Sherwood, N 2003, 'Six novel Gonadotropin releasing hormones are encoded as triplets on each of two genes in the protochordate, Ciona intestinalis.' Endocrinology, vol 144, no. 5.