Dr Javier Tello

Dr Javier Tello
Lecturer in Pharmacology



data source: symbiosis

Research Overview from research@st-andrews

My research interfaces cellular biology, pharmacology, and reproductive physiology, with the goal of understanding and treating fertility disorders emanating from the brain and pituitary. Neuropeptides play a critical role in a number of homeostatic processes, including metabolism, body composition, sleep/wake cycles, response to stress and ageing. However, irregular activity in any one of these processes can usurp normal reproductive function and lead to infertility.

The main goal of my research is to understand how neural networks are modulated by these peptides in the brain relevant to normal development and ageing, and to understand the molecular basis of neuropeptide signalling in both fertile and disease models.

My lab uses transgenic animals, brain slice physiology and molecular approaches to elucidate the cellular events involved with neuroendocrine responses in the hypothalamus and amygdala. We also employ state-of-the art viral vector transduction techniques (e.g. chemogenetics and optogenetics) combined with live calcium imaging and multi-labelling techniques to answer questions related to the neural circuitry underlying these physiological effects. Use of these combined techniques build a powerful arsenal for answering questions related to puberty and fertility.

Current research funding is provided by:

The Northwood Charitable Trust

The Society for Endocrinology - Early Career Grant

The Society for Endocrinology - Equipment Grant

http://www.endocrinology.org/

The British Society for Neuroendocrinology - Project Support Grant

Medical Research Scotland - Summer Studentship


Recent publications listed in research@st-andrews
25 (of 27 published available) for jt65 (source: University of St Andrews PURE)
Please click title of any item for full details

Medial amygdala Kiss1 neurons mediate female pheromone stimulation of luteinizing hormone in male mice Celion Tang, Kirsten Sing, Hyun Wook Kim, Robert P. Millar, Javier Ananda Tello
Neuroendocrinology 2019 vol.108 pp.172–189
Photostimulation for in vitro optogenetics with high power blue organic light-emitting diodes Andrew Morton, Caroline Murawski, Changmin Keum, Gareth Brian Miles, Javier Ananda Tello, Malte Christian Gather
Advanced Biosystems 2019 vol.3 
THE KIAA0319 DYSLEXIA SUSCEPTIBILITY GENE PRESENTS A HIGHLY SPECIFIC EXPRESSION PATTERN DURING ZEBRAFISH DEVELOPMENT AND PLAYS A ROLE IN CYTOSKELETON DYNAMICS Silvia Paracchini, Monika Gostic, Nils Michael Kronenberg, Angela Martinelli, Keith Thomas Sillar, Javier Ananda Tello, Malte Christian Gather
European Neuropsychopharmacology 2019 vol.29 pp.1195-1195
The dyslexia susceptibility KIAA0319 gene shows a specific expression pattern during zebrafish development supporting a role beyond neuronal migration Monika Gostic, Angela Martinelli, Carl Tucker, Zhengyi Yang, Jade-Yi Ewart, Kishan Dholakia, Keith Thomas Sillar, Javier Ananda Tello, Silvia Paracchini
Journal of Comparative Neurology  vol.527 pp.2634-2643
Light-sheet microscopy with attenuation-compensated propagation-invariant beams Jonathan Nylk, Miguel Preciado, Michael Mazilu, Zhengyi Yang, Frank J Gunn-Moore, Javier Ananda Tello, David Ellard Keith Ferrier, Kishan Dholakia
Science Advances 2018 vol.4 
Multimode fibre based imaging for optically cleared samples Jonathan Nylk, Javier Ananda Tello, Kishan Dholakia
Biomedical Optics Express 2017 vol.8 pp.5179-5190
Enhancement of image quality and imaging depth with Airy light-sheet microscopy in cleared and non-cleared neural tissue Jonathan Nylk, Javier Ananda Tello, Kishan Dholakia
Biomedical Optics Express 2016 vol.7 pp.4021-4033
Nanoparticle suspensions enclosed in methylcellulose Christian Hacker, Jalal Asadi, Christos Pliotas, Phedra Marius, Javier Ananda Tello, David Jackson, Jim Naismith, John Milton Lucocq
Scientific Reports 2016 vol.6 
The handedness-associated PCSK6 locus spans an intronic promoter regulating novel transcripts Laura Covill, Kerry Andrea Pettigrew, William A. Brandler, Yiwang Xu, Javier Ananda Tello, Joel B. Talcott, Dianne F. Newbury, John Stein, Anthony P. Monaco, Silvia Paracchini
Human Molecular Genetics 2016 vol.25 pp.1771-1779
At the transition from invertebrates to vertebrates a novel GnRH-like peptide emerges in amphioxus Graeme Roch, Javier Ananda Tello, Nancy Sherwood
Molecular Biology and Evolution 2013 vol.31 pp.765-778
Kisspeptin restores pulsatile LH secretion in patients with neurokinin B signaling deficiencies Jacques Young, Jyothis George, Javier Ananda Tello, Bruno Francou, Jerome Bouligand, Anne Guiochon-Mantel, Sylvie Brailly-Tabard, Richard Anderson, Robert Millar
Neuroendocrinology 2013 vol.97 pp.193-202
Reproductive Physiology of a Humanized GnRH Receptor Mouse Model: Application in Evaluation of Human-Specific Analogues Javier Ananda Tello, Trudy Kohout, Rafael Pineda, Richard Maki, Scott Struthers, Robert Millar
American Journal of Physiology. Endocrinology and Metabolism 2013 
Reproductive neuropeptides Nerine Joseph, Javier Ananda Tello, Gregoy Bedecarrats, Robert Millar
General and Comparative Endocrinology 2013 vol.190 pp.134-43
Congenital hypogonadotropic hypogonadism due to GnRH receptor mutations in three brothers reveal sites affecting conformation and coupling Javier Ananda Tello, Claire Newton, Jerome Bouligand, Anne Guiochon-Mantel, Robert Millar, Jacques Young
PLoS One 2012 vol.7 
Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration Charlotte Sonigo, Justine Bouilly, Nadege Carre, Virginie Tolle, Alain Caraty, Javier Ananda Tello, Fabian-Jesus Simony-Conesa, Robert Millar, Jacques Young, Nadine Binart
The Journal of Clinical Investigation 2012 vol.122 pp.3791-3795
Inactivating KISS1 mutation and hypogonadotropic hypogonadism A Kemal Topaloglu, Javier Ananda Tello, Damla Kotan, Mehmet Ozbek, Bertan Yilmaz, Seref Erdogan, Fatih Gurbuz, Fatih Temiz, Robert Millar, Bilgin Yuksel
New England Journal of Medicine 2012 vol.366 pp.629-635
Kisspeptin antagonists: unraveling the role of kisspeptin in reproductive physiology. Robert Millar, Antonia Roseweir, Javier Ananda Tello, Richard Anderson, Jyothis George, Kevin Morgan, Adam Pawson
Brain Research 2010 
Amphioxus: beginning of vertebrate and end of invertebrate type GnRH receptor lineage. Javier Ananda Tello, Nancy Sherwood
Endocrinology 2009 
Distribution of growth hormone-releasing hormone-like peptide: Immunoreactivity in the central nervous system of the adult zebrafish (Danio rerio). Antonio Castro, Manuela Becerra, Maria Manso, Javier Ananda Tello, Nancy Sherwood, Ramon Anadon
Journal of Comparative Neurology 2009 vol.513 
Isolated familial hypogonadotropic hypogonadism and a GNRH1 mutation Jerome Bouligand, Christina Ghervan, Javier Ananda Tello, Sylvie Brailly-Tabard, Sylvie Salenave, Philippe Chanson, Marc Lombes, Robert Millar, Anne Guiochon-Mantel
New England Journal of Medicine 2009 vol.360 pp.2742-2748
Four functional GnRH receptors in zebrafish: analysis of structure, signaling, synteny and phylogeny. Javier Ananda Tello, Sheng Wu, Jean Rivier, Nancy Sherwood
Integrative and Comparative Biology 2008 
The amphioxus genome illuminates vertebrate origins and cephalochordate biology Linda Z. Holland, Ricard Albalat, Kaoru Azumi, Elia Benito-Gutierrez, Matthew J. Blow, Marianne Bronner-Fraser, Frederic Brunet, Thomas Butts, Simona Candiani, Larry J. Dishaw, David Ellard Keith Ferrier, Jordi Garcia-Fernandez, Jeremy J. Gibson-Brown, Carmela Gissi, Adam Godzik, Finn Hallbook, Dan Hirose, Kazuyoshi Hosomichi, Tetsuro Ikuta, Hidetoshi Inoko, Masanori Kasahara, Jun Kasamatsu, Takeshi Kawashima, Ayuko Kimura, Masaaki Kobayashi, Zbynek Kozmik, Kaoru Kubokawa, Vincent Laudet, Gary W. Litman, Alice C. McHardy, Daniel Meulemans, Masaru Nonaka, Robert P. Olinski, Zeev Pancer, Len A. Pennacchio, Mario Pestarino, Jonathan P. Rast, Isidore Rigoutsos, Marc Robinson-Rechavi, Graeme Roch, Hidetoshi Saiga, Yasunori Sasakura, Masanobu Satake, Yutaka Satou, Michael Schubert, Nancy Sherwood, Takashi Shiina, Naohito Takatori, Javier Ananda Tello, Pavel Vopalensky, Shuichi Wada, Anlong Xu, Yuzhen Ye, Keita Yoshida, Fumiko Yoshizaki, Jr-Kai Yu, Qing Zhang, Christian M. Zmasek, Pieter J. de Jong, Kazutoyo Osoegawa, Nicholas H. Putnam, Daniel S. Rokhsar, Noriyuki Satoh, Peter W. H. Holland
Genome Research 2008 vol.18 pp.1100-1111
Neuroendocrinology of protochordates: insights from Ciona genomics. Nancy Sherwood, Javier Ananda Tello, Graeme Roch
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 2006 
Characterization of four receptor cDNAs Erica Fradinger, Javier Ananda Tello, Jean Rivier, Nancy Sherwood
Molecular and Cellular Endocrinology 2005 vol.231 pp.49-63