Dr Janet Cox-Singh

Dr Janet Cox-Singh
Senior Lecturer


Janet Cox-Singh (JCS) is a research scientist working on malaria. She was fortunate to be instrumental in the discovery of the entry of Plasmodium knowlesi, a malaria parasite adapted to old world macaques, into the human population of Southeast Asia.

JCS conducted her doctoral research on Plasmodium chabaudi, an animal model for malaria, in the Liverpool School of Tropical Medicine (LSTM). Her early postdoctoral research in LSTM was on Brugia pahangi, a model for lymphatic filariasis. She then accepted a lectureship in University Sains Malaysia where she continued her work on lymphatic filariasis and also molecular epidemiology studies tracking the emergence of drug resistance in Plasmodium falciparum.

In 1999 JCS moved to University Malaysia Sarawak (UNIMAS), Malaysian Borneo where the entry of P. knowlesi was discovered. Naturally acquired P. knowlesi malaria was new. The UNIMAS team produced the first clinical descriptions of knowlesi malaria and soon discovered severe and fatal infections. In 2008 JCS returned to the UK as a Senior Research Fellow, St George’s, University of London, to address the question: Why do only some people infected with P. knowlesi develop severe disease? In 2012 Janet Cox-Singh accepted a Senior Lectureship in infection, University of St Andrews, Scotland where she continues her research on P. knowlesi and the pathobiology of severe malaria.

data source: symbiosis

Research Overview from research@st-andrews

Recent publications listed in research@st-andrews
Monsanto Pinheiro, M, Ahmed, MA, Millar, SB, Sanderson, T, Otto, TD, Lu, WC, Krishna, S, Rayner, JC & Cox Singh, J 2015, 'Plasmodium knowlesi genome sequences from clinical isolates reveal extensive genomic dimorphism' PLoS One, vol. 10, no. 4, e0121303. DOI: 10.1371/journal.pone.0121303
Ahmed, AM, Monsanto Pinheiro, M, Divis, PC, Siner, A, Zainudin, R, Wong, IT, Lu, CW, Singh-Khaira, SK, Millar, SB, Lynch, S, Willmann, M, Singh, B, Krishna, S & Cox Singh, J 2014, 'Disease progression in Plasmodium knowlesi malaria is linked to variation in invasion gene family members' PLoS Neglected Tropical Diseases, vol. 8, no. 8, e3086. DOI: 10.1371/journal.pntd.0003086
Fatih, FA, Staines, HM, Siner, A, Ahmed, MA, Woon, LC, Pasini, EM, Kocken, CHM, Singh, B, Cox Singh, J & Krishna, S 2013, 'Susceptibility of human plasmodium knowlesi infections to anti-malarials' Malaria Journal, vol. 12, 425. DOI: 10.1186/1475-2875-12-425
Juul, S, Nielsen, CJF, Labouriau, R, Roy, A, Tesauro, C, Jensen, PW, Harmsen, C, Kristoffersen, EL, Chiu, YL, Frohlich, R, Fiorani, P, Cox-Singh, J, Tordrup, D, Koch, J, Bienvenu, AL, Desideri, A, Picot, S, Petersen, E, Leong, KW, Ho, YP, Stougaard, M & Knudsen, BR 2012, 'Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing plasmodium parasites based on enzyme activity measurement' ACS Nano, vol. 6, no. 12, pp. 10676-10683. DOI: 10.1021/nn3038594
Willmann, M, Ahmed, A, Siner, A, Wong, IT, Woon, LC, Singh, B, Krishna, S & Cox Singh, J 2012, 'Laboratory markers of disease severity in Plasmodium knowlesi infection: a case control study' Malaria Journal, vol. 11, no. 363, 363. DOI: 10.1186/1475-2875-11-363
Fatih, FA, Siner, A, Ahmed, A, Woon, LC, Craig, AG, Singh, B, Krishna, S & Cox Singh, J 2012, 'Cytoadherence and virulence - the case of Plasmodium knowlesi malaria' Malaria Journal, vol. 11, 33. DOI: 10.1186/1475-2875-11-33
Cox-Singh, J, Singh, B, Daneshvar, C, Planche, T, Parker-Williams, J, Krishna, S & Cox Singh, J 2011, 'Anti-inflammatory cytokines predominate in acute human Plasmodium knowlesi infections' PLoS One, vol. 6, no. 6, e20541. DOI: 10.1371/journal.pone.0020541
Lee, K-S, Divis, PCS, Zakaria, SK, Matusop, A, Julin, RA, Conway, DJ, Cox Singh, J & Singh, B 2011, 'Plasmodium knowlesi: reservoir hosts and tracking the emergence in humans and macaques' PLoS Pathogens, vol. 7, no. 4, e1002015. DOI: 10.1371/journal.ppat.1002015
Cox-Singh, J & Cox Singh, J 2010, 'Malaria: what can apes teach humans?' Future Microbiology, vol. 5, no. 8, pp. 1157-1160. DOI: 10.2217/FMB.10.86
Ahouidi, AD, Bei, AK, Neafsey, DE, Sarr, O, Volkman, S, Milner, D, Cox-Singh, J, Ferreira, MU, Ndir, O, Premji, Z, Mboup, S, Duraisingh, MT & Cox Singh, J 2010, 'Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens' Infection Genetics and Evolution, vol. 10, no. 2, pp. 200-206. DOI: 10.1016/j.meegid.2009.11.008
Cox Singh, J, Hiu, J, Lucas, SB, Divis, PC, Zulkarnaen, M, Chandran, P, Wong, KT, Adem, P, Zaki, SR, Singh, B & Krishna, S 2010, 'Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report' Malaria Journal, vol. 9, 10. DOI: 10.1186/1475-2875-9-10
Daneshvar, C, Davis, TME, Cox Singh, J, Rafa'ee, MZ, Zakaria, SK, Divis, PCS & Singh, B 2009, 'Clinical and Laboratory Features of Human Plasmodium knowlesi Infection' Clinical Infectious Diseases, vol. 49, no. 6, pp. 852-860. DOI: 10.1086/605439
Myers, WP, Myers, AP, Cox Singh, J, Lau, HC, Mokuai, B & Malley, R 2009, 'Micro-geographic risk factors for malarial infection' Malaria Journal, vol. 8, 27. DOI: 10.1186/1475-2875-8-27