Dr Janet Cox-Singh

Dr Janet Cox-Singh
Senior Lecturer


Janet Cox-Singh (JCS) is a research scientist working on malaria. She was fortunate to be instrumental in the discovery of the entry of Plasmodium knowlesi, a malaria parasite adapted to old world macaques, into the human population of Southeast Asia.

JCS conducted her doctoral research on Plasmodium chabaudi, an animal model for malaria, in the Liverpool School of Tropical Medicine (LSTM). Her early postdoctoral research in LSTM was on Brugia pahangi, a model for lymphatic filariasis. She then accepted a lectureship in University Sains Malaysia where she continued her work on lymphatic filariasis and also molecular epidemiology studies tracking the emergence of drug resistance in Plasmodium falciparum.

In 1999 JCS moved to University Malaysia Sarawak (UNIMAS), Malaysian Borneo where the entry of P. knowlesi was discovered. Naturally acquired P. knowlesi malaria was new. The UNIMAS team produced the first clinical descriptions of knowlesi malaria and soon discovered severe and fatal infections. In 2008 JCS returned to the UK as a Senior Research Fellow, St George’s, University of London, to address the question: Why do only some people infected with P. knowlesi develop severe disease? In 2012 Janet Cox-Singh accepted a Senior Lectureship in infection, University of St Andrews, Scotland where she continues her research on P. knowlesi and the pathobiology of severe malaria.

data source: symbiosis

Research Overview from research@st-andrews

Recent publications listed in research@st-andrews
25 (of 43 published available) for jcs26 (source: University of St Andrews PURE)
Please click title of any item for full details

Plasmodium knowlesi Janet Cox-Singh
Parasitology 2018 vol.145 pp.1-5
Plasmodium knowlesi Janet Cox-Singh, Richard Culleton
Trends in Parasitology 2015 vol.31 
Plasmodium knowlesi genome sequences from clinical isolates reveal extensive genomic dimorphism Miguel Monsanto Pinheiro, Md Atique Ahmed, Theo Sanderson, Thomas D Otto, Woon Chan Lu, Sanjeev Krishna, Julian C Rayner, Janet Cox-Singh
PLoS One 2015 vol.10 
Plasmodium knowlesi – an emerging pathogen M.A. Ahmed, Janet Cox-Singh
ISBT Science Series 2015 vol.10 pp.134-140
Human infections with Plasmodium knowlesi - zoonotic malaria Janet Cox-Singh
Clinical Microbiology and Infection 2015 vol.21 pp.640-648
Disease progression in Plasmodium knowlesi malaria is linked to variation in invasion gene family members Atique M. Ahmed, Miguel Monsanto Pinheiro, Paul C. Divis, Angela Siner, Ramlah Zainudin, Ing Tien Wong, Chan Woon Lu, Sarina K. Singh-Khaira, Sean Lynch, Matthias Willmann, Balbir Singh, Sanjeev Krishna, Janet Cox-Singh
PLoS Neglected Tropical Diseases 2014 vol.8 
Evaluation of three rapid diagnostic tests for the detection of human infections with Plasmodium knowlesi Deshka Foster, Janet Cox-Singh, Dayang S. A. Mohamad, Sanjeev Krishna, Pek P. Chin, Balbir Singh
Malaria Journal 2014 vol.13 
Susceptibility of human plasmodium knowlesi infections to anti-malarials Farrah A. Fatih, Henry M. Staines, Angela Siner, Mohammed Atique Ahmed, Lu Chan Woon, Erica M. Pasini, Clemens H. M. Kocken, Balbir Singh, Janet Cox-Singh, Sanjeev Krishna
Malaria Journal 2013 vol.12 
Cytoadherence and virulence - the case of Plasmodium knowlesi malaria Farrah A. Fatih, Angela Siner, Atique Ahmed, Lu Chan Woon, Alister G. Craig, Balbir Singh, Sanjeev Krishna, Janet Cox-Singh
Malaria Journal 2012 vol.11 
Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing plasmodium parasites based on enzyme activity measurement Sissel Juul, Christine J F Nielsen, Rodrigo Labouriau, Amit Roy, Cinzia Tesauro, Pia W. Jensen, Charlotte Harmsen, Emil L. Kristoffersen, Ya Ling Chiu, Rikke Frohlich, Paola Fiorani, Janet Cox-Singh, David Tordrup, Jorn Koch, Anne Lise Bienvenu, Alessandro Desideri, Stephane Picot, Eskild Petersen, Kam W. Leong, Yi Ping Ho, Magnus Stougaard, Birgitta R. Knudsen
ACS Nano 2012 vol.6 pp.10676-10683
Laboratory markers of disease severity in Plasmodium knowlesi infection: a case control study Matthias Willmann, Atique Ahmed, Angela Siner, Ing Tien Wong, Lu Chan Woon, Balbir Singh, Sanjeev Krishna, Janet Cox-Singh
Malaria Journal 2012 vol.11 
Zoonotic malaria Janet Cox-Singh
Current Opinion in Infectious Diseases 2012 vol.25 pp.530-536
Plasmodium knowlesi Kim-Sung Lee, Paul C. S. Divis, Siti Khatijah Zakaria, Asmad Matusop, Roynston A. Julin, David J. Conway, Janet Cox-Singh, Balbir Singh
PLoS Pathogens 2011 vol.7 
Anti-inflammatory cytokines predominate in acute human Plasmodium knowlesi infections Janet Cox-Singh, Balbir Singh, Cyrus Daneshvar, Timothy Planche, John Parker-Williams, Sanjeev Krishna, Janet Cox-Singh
PLoS One 2011 vol.6 
Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections Cyrus Daneshvar, Timothy M. E. Davis, Janet Cox-Singh, Mohammad Z. Rafa'ee, Siti K. Zakaria, Paul C. S. Divis, Balbir Singh
Malaria Journal 2010 vol.9 
Malaria: what can apes teach humans? Janet Cox-Singh, Janet Cox-Singh
Future Microbiology 2010 vol.5 pp.1157-1160
Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens Ambroise D. Ahouidi, Amy K. Bei, Daniel E. Neafsey, Ousmane Sarr, Sarah Volkman, Dan Milner, Janet Cox-Singh, Marcelo U. Ferreira, Omar Ndir, Zul Premji, Souleymane Mboup, Manoj T. Duraisingh, Janet Cox-Singh
Infection Genetics and Evolution 2010 vol.10 pp.200-206
Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings Janet Cox-Singh, Jessie Hiu, Sebastian B. Lucas, Paul C. Divis, Mohammad Zulkarnaen, Patricia Chandran, Kum T. Wong, Patricia Adem, Sherif R. Zaki, Balbir Singh, Sanjeev Krishna
Malaria Journal 2010 vol.9 
Plasmodium knowlesi from archival blood films Kim-Sung Lee, Janet Cox-Singh, George Brooke, Asmad Matusop, Balbir Singh
International Journal for Parasitology 2009 vol.39 pp.1125-1128
Clinical and Laboratory Features of Human Plasmodium knowlesi Infection Cyrus Daneshvar, Timothy M. E. Davis, Janet Cox-Singh, Mohammad Zakri Rafa'ee, Siti Khatijah Zakaria, Paul C. S. Divis, Balbir Singh
Clinical Infectious Diseases 2009 vol.49 pp.852-860
Knowlesi malaria in Vietnam Janet Cox-Singh
Malaria Journal 2009 vol.8 
Micro-geographic risk factors for malarial infection Ward P. Myers, Andrea P. Myers, Janet Cox-Singh, Hui C. Lau, Benny Mokuai, Richard Malley
Malaria Journal 2009 vol.8 
Plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening Janet Cox-Singh, Timothy M. E. Davis, Kim-Sung Lee, Sunita S. G. Shamsul, Asmad Matusop, Shanmuga Ratnam, Hasan A. Rahman, David J. Conway, Balbir Singh
Clinical Infectious Diseases 2008 vol.46 pp.165-171
American Journal of Tropical Medicine and Hygiene 2008 vol.79 pp.278-278