Dr Derek Sloan

Dr Derek Sloan
Senior Lecturer



Dr Derek Sloan is a newly appointed Senior Clinical Lecturer and Consultant Infectious Diseases Physician with a joint appointment at the University of St Andrews and NHS Fife. He has previously worked extensively in southern Africa. In 2004, he was worked as a clinician at PCEA Chogoria Hospital in Kenya and supported set-up of an HIV clinic which provided comprehensive roll-out of anti-retroviral therapy for the first time in the district. From 2005-6 he was Senior Medical Officer and Tuberculosis (TB) Lead for Hlabisa sub-district in kwaZulu Natal, South Africa where the dual burden of HIV and drug-resistant TB had become a public health crisis. Subsequently, he completed a Wellcome Trust funded PhD fellowship at the University of Liverpool Institute of Global Health and Liverpool School of Tropical Medicine. His work there was on the clinical pharmacology of TB treatment, and included 2.5 years of combined clinical and academic work in Blantyre, Malawi. During that time he was also an Honorary Lecturer at the University of Malawi College of Medicine, and edited “The Clinical Book”, a practical pocket textbook of local management protocols for common adult medical conditions that still acts as a standard guide for medical students, clinical officers and doctors across the country. In 2015, he spent 3 months in Sierra Leone working as clinical lead on the UK-Med Quality Monitoring Team, supporting the NHS contribution to the Ebola Virus Disease outbreak in West Africa. His ongoing research interests are targeted towards clinical therapeutics questions of global public health significance, particularly in the treatment of tuberculosis and other infections.

data source: symbiosis

Research Overview from research@st-andrews

I have worked in both high and low income countries, accruing extensive experience in the management of infectious diseases, particularly tuberculosis (TB). I have successfully obtained research grant funding and completed a Wellcome Trust fellowship in Liverpool and Malawi, culminating in the award of a PhD from the University of Liverpool.

 

My research is targeted towards clinical therapeutics questions of global public health significance. Presentation and publication of my work has resulted in Young Investigator Awards and prizes at major international conferences. I have ongoing projects on the clinical pharmacology of anti-TB drugs, PK-PD modeling of responses to anti-microbial therapy and programmatic interventions to reduce mortality from infectious diseases in low resource settings.

 

I also have an interest in the acute management of infectious disease outbreaks, and supported the UKMed/NHS response to the Ebola Virus Disease epidemic in West Africa in 2015.


source: research@st-andrews
Recent publications listed in research@st-andrews
Millard, J, Pertinez, H, Bonnett, L, Model, EM, Dartois, V, Johnson, JL, Caws, M, Tiberi, S, Bolhuis, M, Alffenaar, J-WC, Davies, G & Sloan, DJ 2018, 'Linezolid pharmacokinetics in MDR-TB: a systematic review, meta-analysis and Monte Carlo simulation' Journal of Antimicrobial Chemotherapy, vol. 73, no. 7, pp. 1755-1762. DOI: 10.1093/jac/dky096
Kodama, C, Lange, B, Olaru, ID, Khan, P, Lipman, M, Seddon, JA, Sloan, D, Grandjean, L, Abbas Ferrand, R & Kranzer, K 2017, 'Mycobacterium tuberculosis transmission from patients with drug-resistant compared to drug-susceptible TB: a systematic review and meta-analysis' European Respiratory Journal, vol. 50, no. 4, 1701044. DOI: 10.1183/13993003.01044-2017
O’Hara, GA, McNaughton, AL, Maponga, T, Jooste, P, Ocama, P, Chilengi, R, Mokaya, J, Liyayi, MI, Wachira, T, Gikungi, DM, Burbridge, L, O’Donnell, D, Akiror, CS, Sloan, D, Torimiro, J, Yindom, LM, Walton, R, Andersson, M, Marsh, K, Newton, R & Matthews, PC 2017, 'Hepatitis B virus infection as a neglected tropical disease' PLoS Neglected Tropical Diseases, vol. 11, no. 10, e0005842. DOI: 10.1371/journal.pntd.0005842
Sloan, DJ, McCallum, AD, Schipani, A, Egan, D, Mwandumba, HC, Ward, SA, Waterhouse, D, Banda, G, Allain, TJ, Owen, A, Khoo, SH & Davies, GR 2017, 'Genetic determinants of the pharmacokinetic variability of rifampin in Malawian adults with pulmonary tuberculosis' Antimicrobial Agents and Chemotherapy, vol. 61, no. 7, e00210-17. DOI: 10.1128/AAC.00210-17
Hector, J, Anderson, ST, Banda, G, Kamdolozi, M, Jefferys, LF, Shani, D, Garton, NJ, Mwale, A, Jobe, A, Davies, GR & Sloan, DJ 2017, 'TST positivity in household contacts of tuberculosis patients: a case-contact study in Malawi' BMC Infectious Diseases, vol. 17, 259. DOI: 10.1186/s12879-017-2348-2
MacPherson, P, Squire, SB, Cleary , P, Davies, S, Wake, C, Dee, K, Walker, J, Farrow, S, McMaster, P, Woodhead, M, Sloan, DJ & North West TB Audit Steering Committee 2016, 'Equitable tuberculosis care in the North West of England: analysis of tuberculosis cohort review data' International Journal of Tuberculosis and Lung Disease, vol. 20, no. 6, pp. 778-785. DOI: 10.5588/ijtld.15.0772
Wallis, SK, Jehan, K, Woodhead, M, Cleary, P, Dee, K, Farrow, S, McMaster, P, Wake, C, Walker, J, Sloan, DJ & Squire, SB 2016, 'Health professionals' experiences of tuberculosis cohort audit in the North West of England: a qualitative study' BMJ Open, vol. 6, no. 3, e010536. DOI: 10.1136/bmjopen-2015-010536
Sloan, DJ, Mwandumba, HC, Kamdolozi, M, Shani, D, Chisale, B, Dutton, J, Khoo, SH, Allain, TJ & Davies, GR 2015, 'Vitamin D deficiency in Malawian adults with pulmonary tuberculosis: risk factors and treatment outcomes' International Journal of Tuberculosis and Lung Disease, vol. 19, no. 8, pp. 904-911. DOI: 10.5588/ijtld.15.0071
Mzinza, DT, Sloan, DJ, Jambo, KC, Shani, D, Kamdolozi, M, Wilkinson, KA, Wilkinson, RJ, Davies, GR, Heyderman, RS & Mwandumba, HC 2015, 'Kinetics of Mycobacterium tuberculosis-specific IFN-γ responses and sputum bacillary clearance in HIV-infected adults during treatment of pulmonary tuberculosis' Tuberculosis, vol. 95, no. 4, 1343, pp. 463-469. DOI: 10.1016/j.tube.2015.05.009
Sloan, DJ, Mwandumba, HC, Garton, NJ, Khoo, SH, Butterworth, AE, Allain, TJ, Heyderman, RS, Corbett, EL, Barer, MR & Davies, GR 2015, 'Pharmacodynamic modeling of bacillary elimination rates and detection of bacterial lipid bodies in sputum to predict and understand outcomes in treatment of pulmonary tuberculosis' Clinical Infectious Diseases, vol. 61, no. 1, pp. 1-8. DOI: 10.1093/cid/civ195
Gaskell, KM, Rothe, C, Gnanadurai, R, Goodson, P, Jassi, C, Heyderman, RS, Allain, TJ, Harrison, TS, Lalloo, DG, Sloan, DJ & Feasey, NA 2014, 'A prospective study of mortality from cryptococcal meningitis following treatment induction with 1200mg oral fluconazole in Blantyre, Malawi' PLoS One, vol. 9, no. 11, e110285. DOI: 10.1371/journal.pone.0110285
Rothe, C, Sloan, DJ, Goodson, P, Chikafa, J, Mukaka, M, Denis, B, Harrison, T, van Oosterhout, JJ, Heyderman, RS, Lalloo, DG, Allain, T & Feasey, NA 2013, 'A prospective longitudinal study of the clinical outcomes from cryptococcal meningitis following treatment induction with 800 mg oral fluconazole in Blantyre, Malawi' PLoS One, vol. 8, no. 6, e67311. DOI: 10.1371/journal.pone.0067311