Dr Derek Sloan

Dr Derek Sloan
Senior Lecturer



Dr Derek Sloan is a newly appointed Senior Clinical Lecturer and Consultant Infectious Diseases Physician with a joint appointment at the University of St Andrews and NHS Fife. He has previously worked extensively in southern Africa. In 2004, he was worked as a clinician at PCEA Chogoria Hospital in Kenya and supported set-up of an HIV clinic which provided comprehensive roll-out of anti-retroviral therapy for the first time in the district. From 2005-6 he was Senior Medical Officer and Tuberculosis (TB) Lead for Hlabisa sub-district in kwaZulu Natal, South Africa where the dual burden of HIV and drug-resistant TB had become a public health crisis. Subsequently, he completed a Wellcome Trust funded PhD fellowship at the University of Liverpool Institute of Global Health and Liverpool School of Tropical Medicine. His work there was on the clinical pharmacology of TB treatment, and included 2.5 years of combined clinical and academic work in Blantyre, Malawi. During that time he was also an Honorary Lecturer at the University of Malawi College of Medicine, and edited “The Clinical Book”, a practical pocket textbook of local management protocols for common adult medical conditions that still acts as a standard guide for medical students, clinical officers and doctors across the country. In 2015, he spent 3 months in Sierra Leone working as clinical lead on the UK-Med Quality Monitoring Team, supporting the NHS contribution to the Ebola Virus Disease outbreak in West Africa. His ongoing research interests are targeted towards clinical therapeutics questions of global public health significance, particularly in the treatment of tuberculosis and other infections.

data source: symbiosis

Research Overview from research@st-andrews

I have worked in both high and low income countries, accruing extensive experience in the management of infectious diseases, particularly tuberculosis (TB). I have successfully obtained research grant funding and completed a Wellcome Trust fellowship in Liverpool and Malawi, culminating in the award of a PhD from the University of Liverpool.

 

My research is targeted towards clinical therapeutics questions of global public health significance. Presentation and publication of my work has resulted in Young Investigator Awards and prizes at major international conferences. I have ongoing projects on the clinical pharmacology of anti-TB drugs, PK-PD modeling of responses to anti-microbial therapy and programmatic interventions to reduce mortality from infectious diseases in low resource settings.

 

I also have an interest in the acute management of infectious disease outbreaks, and supported the UKMed/NHS response to the Ebola Virus Disease epidemic in West Africa in 2015.

Year

My role

Funding source

 

2016-2019

Co-investigator

EDCTP

HIV/TB diagnostics; a one-stop shop for the same day diagnosis and management of TB and HIV

 

2015-2018

Supervisor/ Advisor

Commonwealth PhD Scholarship/ Epistem

Optimizing the Diagnosis and Management of Tuberculosis (TB) and Diabetes Mellitus (DM) among HIV Patients in a high TB and HIV burden setting (student: Rotimi Owolabi)

 

2015-2018

Primary Supervisor

Wellcome Trust Clinical PhD Fellowship awarded to Dr Andrew McCallum

 

2015-2017

Principal Investigator

British Society for Antimicrobial Chemotherapy Effect of MIC distribution on clinical PK-PD modelling to predict treatment outcome in pulmonary TB patients from Blantyre, Malawi

 

2015-2017

Principal Investigator

Wellcome Trust Institutional Strategic Support Fund Grant to LSTM

Drug resistance in TB: Microbiological & pharmacological variability influencing outcomes

 

2015-2017

Co-investigator

Wellcome Trust Institutional Strategic Support Fund Grant to LSTM

Rational development of an optimal treatment regimen for isoniazid mono-resistant TB

 

2010-2012

Co-investigator & collaborator

Wellcome Trust Masters Training Fellowship awarded to Mr David Mzinza

 

2008-2012

Principal Investigator

Wellcome Trust Clinical PhD Fellowship

 

2008

Principal Investigator

LSTM Equipment Grant

(Awarded to set up a mycobacterial liquid culture facility in BSL3 laboratory)

 


Recent publications listed in research@st-andrews
25 (of 40 published available) for djs26 (source: University of St Andrews PURE)
Please click title of any item for full details

Linezolid for drug-resistant pulmonary tuberculosis Bhagteshwar Singh, Derek Cocker, Hannah Ryan, Derek James Sloan
Cochrane Database of Systematic Reviews 2019 vol.2019 
Protocol for the development of the STrengthening the Reporting of Pharmacogenetic Studies (STROPS) guideline Marty Richardson, Jamie J. Kirkham, Kerry M. Dwan, Derek James Sloan, Geraint R. Davies, Andrea Jorgensen
BMJ Open 2019 vol.9 
CYP genetic variants and toxicity related to anti-tubercular agents: a systematic review and meta-analysis Marty Richardson, Jamie Kirkham, Kerry Dwan, Derek James Sloan, Geraint Davies, Andrea L. Jorgensen
Systematic Reviews 2018 vol.7 
Effect of the duration of antimicrobial exposure on the development of antimicrobial resistance (AMR) for macrolide antibiotics Titus H. Divala, Elizabeth L. Corbett, Helen R. Stagg, Marriott Nliwasa, Derek James Sloan, Neil French, Katherine L. Fielding
Systematic Reviews 2018 vol.7 
Evaluation of the efficacy of two methods for direct extraction of DNA from Mycobacterium tuberculosis sputum Victor Ndhlovu, Wilson Mandala, Derek James Sloan, Mercy Kamdolozi, Maxine Caws, Gerry Davies
Journal of Infection in Developing Countries 2018 vol.12 pp.1067-1072
Linezolid pharmacokinetics in MDR-TB James Millard, Henry Pertinez, Laura Bonnett, Eva Maria Model, Véronique Dartois, John L Johnson, Maxine Caws, Simon Tiberi, Mathieu Bolhuis, Jan-Willem C Alffenaar, Geraint Davies, Derek James Sloan
Journal of Antimicrobial Chemotherapy  vol.73 pp.1755-1762
Sensitivity and specificity of using trial-of-antibiotics versus sputum mycobacteriology for diagnosis of tuberculosis Titus H. Divala, Katherine L. Fielding, Marriott Nliwasa, Derek James Sloan, Ankur Gupta-Wright, Elizabeth L. Corbett
Systematic Reviews 2018 vol.7 
The occurrence and frequency of genomic mutations that mediate Isoniazid and Rifampicin resistance in Mycobacterium tuberculosis isolates from untreated pulmonary Tuberculosis cases in urban Blantyre, Malawi Geoffrey P. Kumwenda, Geoffrey Chipungu, Derek James Sloan, Yankho Kaimila, Kondwani Chiumya, Harry Pangani
Malawi Medical Journal 2018 vol.30 pp.1-5
Mycobacterium tuberculosis transmission from patients with drug-resistant compared to drug-susceptible TB Chiori Kodama, Berit Lange, Ioana D. Olaru, Palwasha Khan, Marc Lipman, James A. Seddon, Derek James Sloan, Louis Grandjean, Rashida Abbas Ferrand, Katharina Kranzer
European Respiratory Journal 2017 vol.50 
Genetic determinants of the pharmacokinetic variability of rifampin in Malawian adults with pulmonary tuberculosis Derek James Sloan, Andrew D. McCallum, Alessandro Schipani, Deirdre Egan, Henry C Mwandumba, Steve A. Ward, David Waterhouse, Gertrude Banda, Theresa J. Allain, Andrew Owen, Saye H Khoo, Geraint R Davies
Antimicrobial Agents and Chemotherapy 2017 vol.61 
Genomic investigation unmasks evidence of transmission across mycobacterium abscessus cystic fibrosis patients Clare Peters, Devesh Janardan Dhasmana, Kerry Andrea Pettigrew, Ramon Fallon, A-l Seagar, Derek James Sloan, If Laurenson, Matthew Holden, Stephen Henry Gillespie
Thorax 2017 vol.72 pp.A56-A56
Hepatitis B virus infection as a neglected tropical disease Geraldine A. O’Hara, Anna L. McNaughton, Tongai Maponga, Pieter Jooste, Ponsiano Ocama, Roma Chilengi, Jolynne Mokaya, Mitchell I. Liyayi, Tabitha Wachira, David M. Gikungi, Lela Burbridge, Denise O’Donnell, Connie S. Akiror, Derek James Sloan, Judith Torimiro, Louis Marie Yindom, Robert Walton, Monique Andersson, Kevin Marsh, Robert Newton, Philippa C. Matthews
PLoS Neglected Tropical Diseases 2017 vol.11 
Influence of genetic variants on toxicity to anti-tubercular agents Marty Richardson, Jamie Kirkham, Kerry Dwan, Derek James Sloan, Geraint Davies, Andrea Jorgensen
Systematic Reviews 2017 vol.6 
TST positivity in household contacts of tuberculosis patients Jonas Hector, Suzanne T. Anderson, Gertrude Banda, Mercy Kamdolozi, Laura F. Jefferys, Doris Shani, Natalie J. Garton, Agnes Mwale, Annie Jobe, Geraint R Davies, Derek James Sloan
BMC Infectious Diseases 2017 vol.17 
The importance of clinical pharmacokinetic–pharmacodynamic studies in unraveling the determinants of early and late tuberculosis outcomes Andrew D McCallum, Derek James Sloan
International Journal of Pharmacokinetics 2017 vol.2 pp.195-212
Equitable tuberculosis care in the North West of England P. MacPherson, S. B. Squire, P. Cleary , S. Davies, C. Wake, K. Dee, J. Walker, S. Farrow, P. McMaster, M. Woodhead, Derek James Sloan,
International Journal of Tuberculosis and Lung Disease 2016 vol.20 pp.778-785
First experience of effectiveness and safety of bedaquiline for 18 months within an optimised regimen for XDR-TB Joseph M Lewis, Paul Hine, Jenny Walker, Saye H Khoo, Miriam Taegtmeyer, S Bertel Squire, Derek James Sloan
European Respiratory Journal 2016 
Health professionals' experiences of tuberculosis cohort audit in the North West of England Selina K. Wallis, Kate Jehan, Mark Woodhead, Paul Cleary, Katie Dee, Stacey Farrow, Paddy McMaster, Carolyn Wake, Jenny Walker, Derek James Sloan, S. B. Squire
BMJ Open 2016 vol.6 
Management of multidrug-resistant TB Derek James Sloan, Joseph M. Lewis
Transactions of the Royal Society of Tropical Medicine and Hygiene 2016 vol.110 pp.163-172
Serial image analysis of Mycobacterium tuberculosis colony growth reveals a persistent subpopulation in sputum during treatment of pulmonary TB David A. Barr, Mercy Kamdolozi, Yo Nishihara, Victor Ndhlovu, Margaret Khonga, Geraint R. Davies, Derek James Sloan
Tuberculosis 2016 vol.98 pp.110-115
Kinetics of Mycobacterium tuberculosis-specific IFN-γ responses and sputum bacillary clearance in HIV-infected adults during treatment of pulmonary tuberculosis David T. Mzinza, Derek James Sloan, Kondwani C. Jambo, Doris Shani, Mercy Kamdolozi, Katalin A. Wilkinson, Robert J. Wilkinson, Geraint R. Davies, Robert S. Heyderman, Henry C. Mwandumba
Tuberculosis 2015 vol.95 pp.463-469
Pharmacodynamic modeling of bacillary elimination rates and detection of bacterial lipid bodies in sputum to predict and understand outcomes in treatment of pulmonary tuberculosis Derek James Sloan, Henry C. Mwandumba, Natalie J. Garton, Saye H. Khoo, Anthony E. Butterworth, Theresa J. Allain, Robert S. Heyderman, Elizabeth L. Corbett, Mike R. Barer, Geraint R. Davies
Clinical Infectious Diseases 2015 vol.61 pp.1-8
The role of delamanid in the treatment of drug-resistant tuberculosis Joseph M. Lewis, Derek James Sloan
Therapeutics and Clinical Risk Management 2015 vol.11 pp.779-791
Tuberculosis in the time of Ebola Derek James Sloan, Tim J. O'Dempsey
International Journal of Tuberculosis and Lung Disease 2015 vol.19 pp.1269