Prof David Harrison

Prof David Harrison
John Reid Chair of Pathology, Director of Research & Director of Laboratory Medicine, NHS Lothian



data source: symbiosis

Research Overview from research@st-andrews

Recent publications listed in research@st-andrews
Lindsay, CR, Shaw, EC, Blackhall, F, Blyth, KG, Brenton, JD, Chaturvedi, A, Clarke, N, Dick, C, Evans, TRJ, Hall, G, Hanby, AM, Harrison, DJ, Johnston, SRD, Mason, MD, Morton, D, Newton-Bishop, J, Nicholson, AG, Oien, KA, Popat, S, Rassl, D, Sharpe, R, Taniere, P, Walker, I, Wallace, WA, West, NP, Butler, R, Gonzalez de Castro, D, Griffiths, M & Johnson, PWM 2018, 'Somatic cancer genetics in the UK: real-world data from phase I of the Cancer Research UK Stratified Medicine Programme' ESMO Open, vol. 3, no. 6, e000408. DOI: 10.1136/esmoopen-2018-000408
Brieu, N, Gavriel, C, Harrison, DJ, Caie, PD & Schmidt, G 2018, Context based interpolation of coarse deep learning prediction maps for the segmentation of fine structures in immunofluorescence images. in JE Tomaszewski & MN Gurcan (eds), Medical Imaging 2018: Digital Pathology., 105810P, Proceedings of SPIE, vol. 10581, SPIE, Symposium: SPIE Medical Imaging , Houston, United States, 10/02/18. DOI: 10.1117/12.2292794
Caie, PD & Harrison, DJ 2018, Digital Pathology: Path to the Future. in Tissue Phenomics : Profiling Cancer Patients for Treatment Decisions. Next-Generation Medicine Vol. 1, Pan Stanford Publishing Ltd, Singapore, pp. 185-198.
Sharma, RS, Harrison, DJ, Kisielewski, D, Cassidy, DM, McNeilly, AD, Gallagher, JR, Walsh, SV, Honda, T, McCrimmon, RJ, Dinkova-Kostova, AT, Ashford, MLJ, Dillon, JF & Hayes, JD 2017, 'Experimental nonalcoholic steatohepatitis and liver fibrosis are ameliorated by pharmacological activation of Nrf2 (NF-E2-related factor 2)' Cellular and Molecular Gastroenterology and Hepatology, vol. 5, no. 3, pp. 367-398. DOI: 10.1016/j.jcmgh.2017.11.016
Van Neste, C, Laird, A, O'Mahony, F, Van Criekinge, W, Deforce, D, Van Nieuwerbugh, F, Powles, T, Harrison, DJ, Stewart, GD & De Meyer, T 2017, 'Epigenetic sampling effects: nephrectomy modifies the clear cell renal cell cancer methylome' Cellular Oncology, vol. 40, no. 3, pp. 293-297. DOI: 10.1007/s13402-016-0313-5
Gremel, G, Djureinovic, D, Niinivirta, M, Laird, A, Ljungqvist, O, Johannesson, H, Bergman, J, Edqvist, P-H, Navani, S, Khan, N, Patil, T, Sivertsson, Å, Uhlén, M, Harrison, DJ, Ullenhag, GJ, Stewart, GD & Pontén, F 2017, 'A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma' BMC Cancer, vol. 17, 9. DOI: 10.1186/s12885-016-3030-6
Meehan, J, Ward, C, Turnbull, A, Bukowski-Wills, J, Finch, A, Jarman, EJ, Xintaropoulou, C, Martinez-Perez, C, Gray, M, Pearson, M, Mullen, P, Supuran, CT, Carta, F, Harrison, DJ, Kunkler, IH & Langdon, S 2017, 'Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells' Oncotarget, vol. 8, no. 26, pp. 42857-42875. DOI: 10.18632/oncotarget.17143
Jamieson, LE, Camus, VL, Bagnaninchi, PO, Fisher, KM, Stewart, GD, Nailon, WH, McLaren, DB, Harrison, DJ & Campbell, CJ 2016, 'Targeted SERS nanosensors measure physicochemical gradients and free energy changes in live 3D tumor spheroids' Nanoscale, vol. 8, no. 37, pp. 16710-16718. DOI: 10.1039/C6NR06031E
Wilkie, RP, Neal, A, Johnston, CA, Voûte, N, Lancefield, CS, Stell, M, Medda, F, Makiyi, EF, Turner, E, Ojo, OS, Slawin, AMZ, Lebl, T, Mullen, P, Harrison, DJ, Ireland, CM & Westwood, NJ 2016, 'Total synthesis of dehaloperophoramidine using a highly diastereoselective Hosomi-Sakurai reaction' Chemical Communications, vol. 52, no. 71, pp. 10747-10750. DOI: 10.1039/c6cc05747k
Van Neste, L, Partin, AW, Stewart, GD, Epstein, JI, Harrison, DJ & Van Criekinge, W 2016, 'Risk score predicts high-grade prostate cancer in DNA-methylation positive, histopathologically negative biopsies' The Prostate, vol. 76, no. 12, pp. 1078-1087. DOI: 10.1002/pros.23191
Martínez-Pérez, C, Ward, C, Turnbull, AK, Mullen, P, Cook, G, Meehan, J, Jarman, EJ, Thomson, PIT, Campbell, CJ, McPhail, D, Harrison, DJ & Langdon, SP 2016, 'Antitumour activity of the novel flavonoid oncamex in preclinical breast cancer models' British Journal of Cancer, vol. 114, no. 8, pp. 905-916. DOI: 10.1038/bjc.2016.6
Gravis, G, Chanez, B, Derosa, L, Beuselinck, B, Barthelemy, P, Laguerre, B, Brachet, P-E, Joly, F, Escudier, B, Harrison, DJ, Laird, A, Vasudev, N, Ralph, C, Larkin, J, Lote, H, Salem, N, Walz, J, Thomassin, J, Sfumato, P, Stewart, GD, Boher, JM & Renal Cross Channel Group 2016, 'Effect of glandular metastases on overall survival of patients with metastatic clear cell renal cell carcinoma in the antiangiogenic therapy era' Urologic Oncology: Seminars and Original Investigations, vol. 34, no. 4, pp. 167.e17-167.e23. DOI: 10.1016/j.urolonc.2015.10.015
Stewart, GD, Powles, T, Van Neste, C, Meynert, A, O'Mahony, F, Laird, A, Deforce, D, Van Nieuwerburgh, F, Trooskens, G, Van Criekinge, W, De Meyer, T & Harrison, DJ 2016, 'Dynamic epigenetic changes to VHL occur with sunitinib in metastatic clear cell renal cancer' Oncotarget, vol. 7, no. 18. DOI: 10.18632/oncotarget.8308
Caie, PD & Harrison, DJ 2016, Next-generation pathology. in U Schmitz & O Wolkenhauer (eds), Systems Medicine. Methods in Molecular Biology, vol. 1386, Humana Press, pp. 61-72. DOI: 10.1007/978-1-4939-3283-2_4
Khalil, HS, Langdon, SP, Goltsov, A, Soininen, T, Harrison, DJ, Brown, J & Deeni, YY 2016, 'A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells' Oncotarget, vol. 7, no. 46, pp. 75874-75901. DOI: 10.18632/oncotarget.12425