Dr Alan Stewart

Dr Alan Stewart
Senior Lecturer in Molecular Medicine

Alan Stewart graduated from the University of Edinburgh with a BSc(Hons) degree in Biochemistry in 1999 and a PhD in 2003. He then took up a postdoctoral fellowship at the Roslin Institute before joining the MRC Human Reproductive Sciences Unit as a Career Development Fellow in 2006. Whilst there his work focussed upon the identification of novel neuroendocrine signalling pathways. In 2009 he moved to the University of St Andrews where he was appointed to a Lectureship, then subsequently to a Senior Lectureship in Molecular Medicine. His research is focussed on metal ions and their roles in health and disease.

School Duties:

  • Research - full details available here
  • Teaching - MD2001 and MD2002 co-module organiser
  • School Safety Officer
  • School Management Group
  • Admissions Interviews
  • Personal Tutor
data source: symbiosis

Research Overview from research@st-andrews

My research is interdisciplinary and sits at the interface between the basic sciences and medicine. Research in my laboratory is focused upon how metal ions are handled in the body and the roles they play in regulating medically/physiologically relevant processes. Collectively, my work provides detailed and reliable data relating to the transport and speciation of metal ions (particularly zinc and calcium) in the circulation and new insights into their cellular functions and role in disease states. Currently my team are examining ways in which defective metal handling contributes to pathogenesis of cardiovascular diseases, including vascular eye disease and dementia.

source: research@st-andrews
Recent publications listed in research@st-andrews
Jovanovic, A, Obradovic, M, Sudar-Milovanovic, E, Stewart, AJ, Pitt, SJ, Alvantic, D, Aleksic, E & Isenovic, ER 2017, 'Changes in cardiac Na+/K+-ATPase expression and activity in female rats fed a high fat diet' Molecular and Cellular Biochemistry, vol 436, no. 1-2, pp. 49-58. DOI: 10.1007/s11010-017-3077-y
Jovanovic, A, Sudar-Milovanovic, E, Obradovic, M, Pitt, SJ, Stewart, AJ, Zafirovic, S, Stanimirovic, J, Radak, D & Isenovic, ER 2017, 'Influence of a high-fat diet on cardiac iNOS in female rats' Current Vascular Pharmacology, vol 15, no. 5, pp. 491-500. DOI: 10.2174/1570161114666161025101303
Handing, KB, Shabalin, IG, Kassaar, O, Khazaipoul, S, Blindauer, CA, Stewart, AJ, Chruszcz, M & Minor, W 2016, 'Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins' Chemical Science, vol 7, no. 11, pp. 6635-6648. DOI: 10.1039/C6SC02267G
Stanimirovic, J, Obradovic, M, Jovanovic, A, Sudar-Milovanovic, E, Zafirovic, S, Pitt, SJ, Stewart, AJ & Isenovic, ER 2016, 'A high fat diet induces sex-specific differences in hepatic lipid metabolism and nitrite/nitrate in rats' Nitric Oxide, vol 54, pp. 51-59. DOI: 10.1016/j.niox.2016.02.007
Obradovic, M, Stewart, AJ, Pitt, SJ, Labudovic-Borovic, M, Sudar, E, Petrovic, V, Zafirovic, S, Maravic-Stojkovic, V, Vasic, V & Isenovic, ER 2014, 'In vivo effects of 17β-estradiol on cardiac Na+/K+-ATPase expression and activity in rat heart' Molecular and Cellular Endocrinology, vol 388, no. 1-2, pp. 58-68. DOI: 10.1016/j.mce.2014.03.005
Popovics, P, Lu, J, Kamil, LN, Morgan, K, Millar, RP, Schmid, R, Blindauer, CA & Stewart, AJ 2014, 'A canonical EF-loop directs Ca2+-sensitivity in phospholipase C-η2' Journal of Cellular Biochemistry, vol 115, no. 3, pp. 557–565. DOI: 10.1002/jcb.24690
Barnett, JP, Blindauer, CA, Kassaar, O, Khazaipoul, S, Martin, EM, Sadler, PJ & Stewart, AJ 2013, 'Allosteric modulation of zinc speciation by fatty acids' Biochimica et Biophysica Acta - General Subjects, vol 1830, no. 12, pp. 5456-5464. DOI: 10.1016/j.bbagen.2013.05.028
Obradovic, M, Bjelogrlic, P, Rizzo, M, Katsiki, N, Haidara, M, Stewart, AJ, Jovanovic, A & Isenovic, ER 2013, 'Effects of obesity and estradiol on Na+/K+-ATPase and their relevance to cardiovascular disease' Journal of Endocrinology, vol 218, pp. R13-R23. DOI: 10.1530/JOE-13-0144
Popovics, P, Gray, A, Arastoo, M, Finelli, DK, Tan, AJL & Stewart, AJ 2013, 'Phospholipase C-η2 is required for retinoic acid-stimulated neurite growth' Journal of Neurochemistry, vol 124, no. 5, pp. 632-644. DOI: 10.1111/jnc.12122
Kassaar, O, Powis, SJ & Stewart, AJ 2012, The formation and Zn2+-dependence of histidine-rich glycoprotein-containing immune complexes. in LV Berhardt (ed.), Advances in Medicine and Biology. vol. 58, Nova Science Publishers, pp. 153-166.
Majorek, KA, Porebski, PJ, Dayal, A, Zimmerman, MD, Jablonska, K, Stewart, AJ, Chruszcz, M & Minor, W 2012, 'Structural and immunologic characterization of bovine, horse, and rabbit serum albumins' Molecular Immunology, vol 52, no. 3-4, pp. 174-182. DOI: 10.1016/j.molimm.2012.05.011