Dr Alan Stewart

Dr Alan Stewart
Senior Lecturer in Molecular Medicine

Alan Stewart graduated from the University of Edinburgh with a BSc(Hons) degree in Biochemistry in 1999 and a PhD in 2003. He then took up a postdoctoral fellowship at the Roslin Institute before joining the MRC Human Reproductive Sciences Unit as a Career Development Fellow in 2006. Whilst there his work focussed upon the identification of novel neuroendocrine signalling pathways. In 2009 he moved to the University of St Andrews where he was appointed to a Lectureship, then subsequently to a Senior Lectureship in Molecular Medicine. His research is focussed on metal ions and their roles in health and disease.

School Duties:

  • Research - full details available here
  • Teaching - MD2001 and MD2002 co-module organiser
  • School Safety Officer
  • School Management Group
  • Admissions Interviews
  • Personal Tutor
data source: symbiosis

Research Overview from research@st-andrews

My research is interdisciplinary and sits at the interface between the basic sciences and medicine. Research in my laboratory is focused upon how metal ions are handled in the body and the roles they play in regulating medically/physiologically relevant processes. Collectively, my work provides detailed and reliable data relating to the transport and speciation of metal ions (particularly zinc and calcium) in the circulation and new insights into their cellular functions and role in disease states. Currently my team are examining ways in which defective metal handling contributes to pathogenesis of cardiovascular diseases, including vascular eye disease and dementia.

Recent publications listed in research@st-andrews
25 (of 66 published available) for ajs21 (source: University of St Andrews PURE)
Please click title of any item for full details

A metalloproteomic analysis of interactions between plasma proteins and zinc: elevated fatty acid levels affect zinc distribution James P. C. Coverdale, James P. Barnett, Adamu Adamu, Ellie Griffiths, Alan J. Stewart, Claudia A. Blindauer
Changes in plasma free fatty acids associated with type-2 diabetes Claudia A. Blindauer, Alan J. Stewart
Nutrients 2019 vol.11 
Crosstalk between zinc and fatty acids in plasma James P C Coverdale, Siavash Khazaipoul, Swati Arya, Alan J. Stewart, Claudia A Blindauer
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 2019 vol.1864 pp.532-542
On the origin of proteins in human drusen Arthur A. Bergen, Swati Arya, Celine Koster, Matthew G. Pilgrim, Peter van der Spek, Stefanie M. Hauck, Camiel J. F. Boon, Eszter Emri, Alan J. Stewart, Imre Lengyel
Progress in Retinal and Eye Research 2019 vol.70 pp.55-84
Plasma non-esterified fatty acids contribute to increased coagulability in type-2 diabetes through altered plasma zinc speciation Fladia A. Phoenix, Siavash Khazaipoul, Ruitao Yu, Fanuel Lampiao, Fiona Stefanowicz, Claudia A. Blindauer, Samantha J. Pitt, Terry K Smith, Ramzi A. Ajjan, Alan J. Stewart
biorxiv 2019 
Quantitative proteomic changes in LPS-activated monocyte-derived dendritic cells Swati Arya, Silvia Anna Synowsky, Sally Lorna Shirran, Catherine Helen Botting, Simon John Powis, Alan J. Stewart
Scientific Reports 2019 vol.9 
Sub-micromolar pulse dipolar EPR spectroscopy reveals increasing CuII-labelling of double-histidine motifs with lower temperature Katrin Ackermann, Alan J. Stewart, David Norman, Bela Ernest Bode
Angewandte Chemie 2019 vol.131 pp.11807-11811
Sub-micromolar pulse dipolar EPR spectroscopy reveals increasing CuII-labelling of double-histidine motifs with lower temperature Katrin Ackermann, Alan J. Stewart, David G. Norman, Bela Ernest Bode
Angewandte Chemie - International Edition 2019 vol.58 pp.11681-11685
Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes Fiona Stefanowicz, Samantha J. Pitt, Ramzi A. Ajjan, Alan J. Stewart
BioMetals 2019 vol.32 pp.123-138
Erythritol attenuates postprandial blood glucose by inhibiting α-glucosidase Huaixiu Wen, Bowen Tang, Alan J. Stewart, Yanduo Tao, Yun Shao, Yulei Cui, Huilan Yue, Jinjin Pei, Zenggen Liu, Lijuan Mei, Ruitao Yu, Lei Jiang
Journal of Agricultural and Food Chemistry 2018 vol.66 pp.1401-1407
Glycosaminoglycan neutralization in coagulation control Samantha J. Pitt, Alan J. Stewart
Arteriosclerosis, Thrombosis, and Vascular Biology 2018 vol.38 pp.1258-1270
Influence of zinc on glycosaminoglycan neutralisation during coagulation Samantha J. Pitt, Alan J. Stewart
Metallomics 2018 vol.10 pp.1180-1190
Ischemia-modified albumin James P C Coverdale, Swati Arya, Claudia A Blindauer, Alan J. Stewart
Prostaglandins, Leukotrienes and Essential Fatty Acids 2018 vol.135 pp.147-157
Native electrospray mass spectrometry approaches to probe the interaction between zinc and an anti-angiogenic peptide from histidine-rich glycoprotein Esther M. Martin, Frances D. L. Kondrat, Alan J. Stewart, James H. Scrivens, Peter J. Sadler, Claudia A. Blindauer
Scientific Reports 2018 vol.8 
PLA2 and ENPP6 may act in concert to generate phosphocholine from the matrix vesicle membrane during skeletal mineralization Alan J. Stewart, Darren T K Leong, Colin Farquharson
FASEB Journal 2018 vol.32 pp.20-25
Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration Swati Arya, Eszter Emri, Silvia Anna Synowsky, Sally Lorna Shirran, Neda Barzegar-Befroei, Tunde Peto, Catherine Helen Botting, Imre Lengyel, Alan J. Stewart
Experimental Eye Research 2018 vol.172 pp.21-29
17ß-Estradiol protects against the effects of a high fat diet on cardiac glucose, lipid and nitric oxide metabolism in rats Sonja Zafirovic, Milan Obradovic, Emina Sudar-Milovanovic, Alexsandra Jovanovic, Julijana Stanimirovic, Alan J. Stewart, Samantha J. Pitt, Esma R. Isenovic
Molecular and Cellular Endocrinology 2017 vol.446 pp.12-20
Changes in cardiac Na+/K+-ATPase expression and activity in female rats fed a high fat diet Aleksandra Jovanovic, Milan Obradovic, Emina Sudar-Milovanovic, Alan J. Stewart, Samantha J. Pitt, Dragan Alvantic, Ema Aleksic, Esma R. Isenovic
Molecular and Cellular Biochemistry 2017 vol.436 pp.49-58
Dysregulated Zn2+ homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca2+ leakage Angela Karumbi, Connor McIntyre, Wojciech Bal, Miyuki Nishi, Hiroshi Takeshima, Alan J. Stewart, Samantha J. Pitt
Journal of Biological Chemistry 2017 vol.292 pp.13361-13373
Influence of a high-fat diet on cardiac iNOS in female rats Aleksandra Jovanovic, Emina Sudar-Milovanovic, Milan Obradovic, Samantha J. Pitt, Alan J. Stewart, Sonja Zafirovic, Julijana Stanimirovic, Djordje Radak, Esma R. Isenovic
Current Vascular Pharmacology 2017 vol.15 pp.491-500
A high fat diet induces sex-specific differences in hepatic lipid metabolism and nitrite/nitrate in rats Julijana Stanimirovic, Milan M Obradovic, Aleksandra Jovanovic, Emina Sudar-Milovanovic, Sonja Zafirovic, Samantha J. Pitt, Alan J. Stewart, Esma R Isenovic
Nitric Oxide 2016 vol.54 pp.51-59
Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins Katarzyna Handing, Ivan G Shabalin, Siavash Khazaipoul, Claudia A Blindauer, Alan J. Stewart, Maksymilian Chruszcz, Wladek Minor
Chemical Science 2016 vol.7 pp.6635-6648
Fatty acid-mediated inhibition of metal binding to the multi-metal site on serum albumin Claudia A. Blindauer, Siavash Khazaipoul, Ruitao Yu, Alan J. Stewart
Current Topics in Medicinal Chemistry 2016 vol.16 pp.3021-3032
Phospholipase C-η2 interacts with nuclear and cytoplasmic LIMK-1 during retinoic acid-stimulated neurite growth Christian Hacker, John Milton Lucocq, Alan J. Stewart
Histochemistry and Cell Biology 2016 vol.145 pp.163-173
Response to Qian and Colvin Jason Woodier, Richard D Rainbow, Alan J. Stewart, Samantha J. Pitt
Journal of Biological Chemistry 2016 vol.291 pp.4267