Prof Andy Lynch

Prof Andy Lynch
Professor of Statistics in Bioscience



data source: symbiosis

Research Overview from research@st-andrews

Recent publications listed in research@st-andrews
25 (of 89 published available) for agl4 (source: University of St Andrews PURE)
Please click title of any item for full details

Deciphering the genomic, epigenomic and transcriptomic landscapes of pre-invasive lung cancer lesions Vitor H. Texeira, Chrisodoulos P. Pipinikas, Adam Pennycuick, Henry Lee-Six, Deepak Chandrasekharan, Jennifer Beane, Tiffany J. Morris, Anna Karpathakis, Andrew Feber, Charles E. Breeze, Paschalis Ntolios, Robert E. Hynds, Mary Falzon, Arrigo Capitanio, Bernadette Carroll, Pascal F. Durrenberger, Georgia Hardavella, James M. Brown, Andy Lynch, Henry Farmery, Dirk S. Paul, Rachel C. Chambers, Nicholas McGranahan, Neal Navani, Ricky M. Thakrar, Charles Swanton, Stephan Beck, Philip Jeremy George, Avrum Spira, Peter J. Campbell, Christina Thirwell, Sam M. Jones
Nature Medicine 2019 vol.25 pp.517-525
DESNT Bogdan-Alexandru Luca, Daniel S. Brewer, Dylan R. Edwards, Sandra Edwards, Hayley C. Whitaker, Sue Merson, Nening Dennis, Rosalin A. Cooper, Steven Hazell, Anne Y. Warren, Rosalind Eeles, Andy Lynch, Helen Ross-Adams, Alastair D. Lamb, David E. Neal, Krishna Sethia, Robert D. Mills, Richard Y. Ball, Helen Curley, Jeremy Clark, Vincent Moulton, Colin S. Cooper
European Urology Focus 2018 vol.4 pp.842-850
Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets David C. Wedge, Gunes Gundem, Thomas Mitchell, Dan J. Woodstock, Inigo Martincorena, Mohammed Ghori, Jorge Zamora, Adam Butler, Hayley Whitaker, Zsofia Kote-Jarai, Lumil B. Alexandrov, Peter Van Loo, Charlie E. Massie, Stefan Dentro, Anne Y. Warren, Clare Verrill, Dan M. Berney, Nening Dennis, Sue Merson, Steve Hawkins, William Howat, Yong-Jie Lu, Adam Lambert, Jonathan Kay, Barbara Kremeyer, Katalin Karaszi, Niedzica Camacho, Hayley Luxton, Luke Marsden, Sandra Edwards, Lucy Matthews, Valeria Bo, Daniel Leongamornlert, Stuart McLaren, Anthony Ng, Yongwei Yu, Hongwei Zhang, Tokhir Dadaev, Sarah Thomas, Douglas F. Easton, Mahbubl Ahmed, Elizabeth Bancroft, Cyril Fisher, Naomi Livni, David Nicol, Simon Tavaré, Pelvender Gill, Christopher Greenman, Vincent Khoo, Nicholas Van As, Pardeep Kumar, Christopher Ogden, Declan Cahill, Alan Thompson, Erik Mayer, Edward Rowe, Tim Dudderidge, Vincent Gnanapragasam, Nimish C. Shah, Keiran Raine, David Jones, Andrew Menzies, Lucy Stebbings, Jon Teague, Steven Hazell, Cathy Corbishley, Johann de Bono, Gerhardt Attard, William Isaacs, Tapio Visakorpi, Michael Fraser, Paul C. Boutros, Robert G. Bristow, Paul Workman, Chris Sander, Freddie C. Hamdy, Andrew Futreal, Ultan McDermott, Bissan Al-Lazikani, Andy Lynch, G. Steven Bova, Christopher S. Foster, Daniel S. Brewer, David E. Neal, Colin S. Cooper, Rosalind A. Eeles
Nature Genetics 2018 vol.50 pp.682-692
Telomerecat James Farmery, Mike Smith, Andy Lynch
Scientific Reports 2018 vol.8 
The role of TET-mediated DNA hydroxymethylation in prostate cancer E Smeets, Andy Lynch, S Prekovic, T Van den Broeck, L Moris, C Helsen, S Joniau, F Claessens, C E Massie
Molecular and Cellular Endocrinology 2018 vol.462 pp.41-55
Timing the landmark events in the evolution of clear cell renal cell cancer Thomas J. Mitchell, Samra Turajlic, Andrew Rowan, David Nicol, James H.R. Farmery, Tim O’Brien, Inigo Martincorena, Patrick Tarpey, Nicos Angelopoulos, Lucy R. Yates, Adam P. Butler, Keiran Raine, Grant D. Stewart, Ben Challacombe, Archana Fernando, Jose I. Lopez, Steve Hazell, Ashish Chandra, Simon Chowdhury, Sarah Rudman, Aspasia Soultati, Gordon Stamp, Nicos Fotiadis, Lisa Pickering, Lewis Au, Lavinia Spain, Joanna Lynch, Mark Stares, Jon Teague, Francesco Maura, David C. Wedge, Stuart Horswell, Tim Chambers, Kevin Litchfield, Hang Xu, Aengus Stewart, Reza Elaidi, Stéphane Oudard, Nicholas McGranahan, Istvan Csabai, Martin Gore, P. Andrew Futreal, James Larkin, Andy Lynch, Zoltan Szallasi, Charles Swanton, Peter J. Campbell
Cell 2018 vol.173 pp.611-623
A comparative analysis of whole genome sequencing of esophageal adenocarcinoma pre- and post-chemotherapy Ayesha Noorani, Jan Bornschein, Andy Lynch, Maria Secrier, Achilleas Achilleos, Matthew Eldridge, Lawrence Bower, Jamie M.J. Weaver, Jason Crawte, Chin-Ann Ong, Nicholas Shannon, Shona MacRae, Nicola Grehan, Barbara Nutzinger, Maria O'Donovan, Richard Hardwick, Simon Tavaré, Rebecca C. Fitzgerald,
Genome Research 2017 vol.27 pp.902-912
Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data Niedzica Camacho, Peter Van Loo, Sandra Edwards, Jonathan D Kay, Lucy Matthews, Kerstin Haase, Jeremy Clark, Nening Dennis, Sarah Thomas, Barbara Kremeyer, Jorge Zamora, Adam P. Butler, Gunes Gundem, Sue Merson, Hayley Luxton, Steve Hawkins, Mohammed Ghori, Luke Marsden, Adam Lambert, Katalin Karaszi, Gill Pelvender, Charlie E. Massie, Zsofia Kote-Jarai, Keiran Raine, David Jones, William J. Howat, Steven Hazell, Naomi Livni, Cyril Fisher, Christopher Ogden, Pardeep Kumar, Alan Thompson, David Nicol, Erik Mayer, Tim Dudderidge, Yongwei Yu, Hongwei Zhang, Nimish C. Shah, Vincent J. Gnanapragasam, The CRUK-ICGC Prostate Group, William Isaacs, Tapio Visakorpi, Freddie Hamdy, Dan Berney, Clare Verrill, Anne Y. Warren, David C. Wedge, Andy Lynch, Christopher S. Foster, Yong-Jie Lu, G. Steven Bova, Hayley C. Whitaker, Ultan McDermott, David E. Neal, Rosalind Eeles, Colin S. Cooper, Daniel S. Brewer
PLoS Genetics 2017 vol.13 
Genomic evolution of breast cancer metastasis and relapse Lucy R. Yates, Stian Knappskog, David Wedge, James H R Farmery, Santiago Gonzalez, Inigo Martincorena, Ludmil B. Alexandrov, Peter Van Loo, Hans Kristian Haugland, Peer Kaare Lilleng, Gunes Gundem, Moritz Gerstung, Elli Pappaemmanuil, Patrycja Gazinska, Shriram G Bhosle, David Jones, Keiran Raine, Laura Mudie, Calli Latimer, Elinor Sawyer, Christine Desmedt, Christos Sotiriou, Michael R. Stratton, Anieta M Sieuwerts, Andy Lynch, John W Martens, Andrea L. Richardson, Andrew Tutt, Per Eystein Lønning, Peter J. Campbell
Cancer Cell 2017 vol.32 pp.169-184
Mining human prostate cancer datasets Mark J. Dunning, Sarah L. Vowler, Emilie Lalonde, Helen Ross-Adams, Paul Boutros, Ian G Mills, Andy Lynch, Alastair D. Lamb
EBioMedicine 2017 vol.17 pp.5-6
New model for estimating glomerular filtration rate in patients with cancer Tobias Janowitz, Edward H. Williams, Andrea Marshall, Nicola Ainsworth, Peter B. Thomas, Stephen J. Sammut, Scott Shepherd, Jeff White, Patrick B. Mark, Andy Lynch, Duncan I. Jodrell, Simon Tavaré, Helena Earl
Journal of Clinical Oncology 2017 vol.35 pp.2798-2805
Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer Mohammad Asim, Firas Tarish, Heather I. Zecchini, Kumar Sanjiv, Eleni Gelali, Charles E. Massie, Ajoeb Baridi, Anne Y. Warren, Wanfeng Zhao, Christoph Ogris, Leigh-Anne McDuffus, Patrice Mascalchi, Greg Shaw, Harveer Dev, Karan Wadhwa, Paul Wijnhoven, Josep V Forment, Scott R Lyons, Andy Lynch, Cormac O'Neill, Vincent R. Zecchini, Paul S. Rennie, Aria Baniahmad, Simon Tavaré, Ian G Mills, Yaron Galanty, Nicola Crosetto, Niklas Schultz, David Neal, Thomas Helleday
Nature Communications 2017 vol.8 
The importance of DNA methylation in prostate cancer development Charles E. Massie, Ian G Mills, Andy Lynch
The Journal of Steroid Biochemistry and Molecular Biology 2017 vol.166 pp.1-15
Authentication and characterisation of a new oesophageal adenocarcinoma cell line Edwin Garcia, Annette Hayden, Charles Birts, Edward Britton, Andrew Cowie, Karen Pickard, Massimiliano Mellone, Clarisa Choh, Mathieu Derouet, Patrick Duriez, Fergus Noble, Michael J. White, John N. Primrose, Jonathan C. Strefford, Matthew Rose-Zerilli, Gareth J. Thomas, Yeng Ang, Andrew D. Sharrocks, Rebecca C. Fitzgerald, Timothy J. Underwood, Andy Lynch
Scientific Reports 2016 vol.6 
Cholinekinase alpha as an androgen receptor chaperone and prostate cancer therapeutic target Mohammad Asim, Charles E. Massie, Folake Orafidiya, Nelma Pértega-Gomes, Anne Y. Warren, Mohsen Esmaeili, Luke A. Selth, Heather I. Zecchini, Katarina Luko, Arham Qureshi, Ajoeb Baridi, Suraj Menon, Basetti Madhu, Carlos Escriu, Scott Lyons, Sarah L. Vowler, Vincent R. Zecchini, Greg Shaw, Wiebke Hessenkemper, Roslin Russell, Hisham Mohammed, Niki Stefanos, Andy Lynch, Elena Grigorenko, Clive D’Santos, Chris Taylor, Alastair Lamb, Rouchelle Sriranjan, Jiali Yang, Rory Stark, Scott M. Dehm, Paul S. Rennie, Jason S. Carroll, John R. Griffiths, Simon Tavaré, Ian G Mills, Iain J. McEwan, Aria Baniahmad, Wayne D. Tilley, David E. Neal
Journal of the National Cancer Institute 2016 vol.108 
Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance Maria Secrier, Xiaodun Li, Nadeera De Silva, Matthew D. Eldridge, Gianmarco Contino, Jan Bornschein, Shona MacRae, Nicola Grehan, Maria O'Donovan, Ahmad Miremadi, Tsun Po Yang, Lawrence Bower, Hamza Chettouh, Jason Crawte, Núria Galeano-Dalmau, Anna Grabowska, John Saunders, Tim Underwood, Nicola Waddell, Andrew P Barbour, Barbara Nutzinger, Achilleas Achilleos, Paul A.W. Edwards, Andy Lynch, Simon Tavare, Rebecca C. Fitzgerald,
Nature Genetics 2016 vol.48 pp.1131-1141
Mutational signatures of ionizing radiation in second malignancies Sam Behjati, Gunes Gundem, David C. Wedge, Nicola D. Roberts, Patrick S. Tarpey, Susanna L. Cooke, Peter Van Loo, Ludmil B. Alexandrov, Manasa Ramakrishna, Helen Davies, Serena Nik-Zainal, Claire Hardy, Calli Latimer, Keiran M. Raine, Lucy Stebbings, Andy Menzies, David Jones, Rebecca Shepherd, Adam P. Butler, Jon W. Teague, Mette Jorgensen, Bhavisha Khatri, Nischalan Pillay, Adam Shlien, P. Andrew Futreal, Christophe Badie, Ultan McDermott, G. Steven Bova, Andrea L. Richardson, Adrienne M. Flanagan, Michael R. Stratton, Peter J. Campbell, Andy Lynch
Nature Communications 2016 vol.7 
The early effects of rapid androgen deprivation on human prostate cancer Greg L. Shaw, Hayley Whitaker, Marie Corcoran, Mark J. Dunning, Hayley Luxton, Jonathan Kay, Charlie E. Massie, Jodi L. Miller, Alastair D. Lamb, Helen Ross-Adams, Roslin Russell, Adam W. Nelson, Matthew D. Eldridge, Andy Lynch, Antonio Ramos-Montoya, Ian G Mills, Angela E. Taylor, Wiebke Arlt, Nimish Shah, Anne Y. Warren, David E. Neal
European Urology 2016 vol.70 pp.214-218
Using Methylation Patterns for Reconstructing Cell Division Dynamics D. J. Andrews, Andy Lynch, S. Tavaré
 2016 pp.3-15
Whole blood mRNA in prostate cancer reveals a four-gene androgen regulated panel Benjamin C Thomas, Jonathan D Kay, Suraj Menon, Sarah L. Vowler, Sarah N Dawson, Laura J Bucklow, Hayley J. Luxton, Thomas Johnston, Charlie E. Massie, Michelle Pugh, Anne Y. Warren, Peter Barker, Keith Burling, Andy Lynch, Anne George, Johanna Burge, Marie Corcoran, Sara Stearn, Alastair D. Lamb, Naomi L Sharma, Greg L. Shaw, David E. Neal, Hayley C. Whitaker
Endocrine-Related Cancer 2016 vol.23 pp.797-812
Whole-genome sequencing of nine esophageal adenocarcinoma cell lines Gianmarco Contino, Matthew D. Eldridge, Maria Secrier, Lawrence Bower, Rachael Fels Elliott, Jamie Weaver, Andy Lynch, Paul A.W. Edwards, Rebecca C. Fitzgerald
F1000Research 2016 vol.5 
5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer Santiago Uribe-Lewis, Rory Stark, Thomas Carroll, Mark J. Dunning, Martin Bachman, Yoko Ito, Lovorka Stojic, Silvia Halim, Sarah L. Vowler, Andy Lynch, Benjamin Delatte, Eric J. de Bony, Laurence Colin, Matthieu Defrance, Felix Krueger, Ana Luisa Silva, Rogier ten Hoopen, Ashraf E.K. Ibrahim, François Fuks, Adele Murrell
Genome Biology 2015 vol.16 
A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing Tyler S. Alioto, Ivo Buchhalter, Sophia Derdak, Barbara Hutter, Matthew D. Eldridge, Eivind Hovig, Lawrence E. Heisler, Timothy A. Beck, Jared T. Simpson, Laurie Tonon, Anne-Sophie Sertier, Ann-Marie Patch, Natalie Jaeger, Philip Ginsbach, Ruben Drews, Nagarajan Paramasivam, Rolf Kabbe, Sasithorn Chotewutmontri, Nicolle Diessl, Christopher Previti, Sabine Schmidt, Benedikt Brors, Lars Feuerbach, Michael Heinold, Susanne Groebner, Andrey Korshunov, Patrick S. Tarpey, Adam P. Butler, Jonathan Hinton, David Jones, Andrew Menzies, Keiran Raine, Rebecca Shepherd, Lucy Stebbings, Jon W. Teague, Paolo Ribeca, Francesc Castro Giner, Sergi Beltran, Emanuele Raineri, Marc Dabad, Simon C. Heath, Marta Gut, Robert E. Denroche, Nicholas J. Harding, Takafumi N. Yamaguchi, Akihiro Fujimoto, Hidewaki Nakagawa, Ctor Quesada, Rafael Valdes-Mas, Sigve Nakken, Daniel Vodak, Lawrence Bower, Andy Lynch, Charlotte L. Anderson, Nicola Waddell, John V. Pearson, Sean M Grimmond, Myron Peto, Paul Spellman, Minghui He, Cyriac Kandoth, Semin Lee, John Zhang, Louis Letourneau, Singer Ma, Sahil Seth, David Torrents, Liu Xi, David A. Wheeler, Carlos Lopez-Otin, Elias Campo, Peter J. Campbell, Paul C. Boutros, Xose S. Puente, Daniela S. Gerhard, Stefan M. Pfister, John D. McPherson, Thomas J. Hudson, Matthias Schlesner, Peter Lichter, Roland Eils, David T. W. Jones, Ivo G. Gut
Nature Communications 2015 vol.6 
A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer Hans Kristian Moen Vollan, Oscar M. Rueda, Suet Feung Chin, Christina Curtis, Gulisa Turashuili, Sohrab Shah, Ole Christian Lingjaerde, Yinyin Yuan, Charlotte K. Ng, Mark J. Dunning, Ed Dicks, Elena Provenzano, Stephen Sammut, Steven McKinney, Ian O. Ellis, Sarah Pinder, Arnie Purushotham, Leigh C. Murphy, Vessela N. Kristensen, James D. Brenton, Paul D. P. Pharoah, Anne-Lise Borresen-Dale, Samuel Aparicio, Carlos Caldas, Andy Lynch
Molecular Oncology 2015 vol.9 pp.115-127