Dr Jo Parish has been awarded £150,000 from Medical Research Scotland for a 3 year project entitled "A structural study of ChlR1, a DNA helicase required for sister chromatid cohesion and papillomavirus genome persistence".
Cell division is important for the growth and maintenance of all cell populations. As cells divide all DNA is copied and accurately segregated into the subsequent daughter cells. Failure of this process results in genetic instability, an important step towards cancer. We have shown that a novel enzyme termed ChlR1 is required for the accurate segregation of chromosomes. ChlR1 is also required for the long term persistence of human papillomavirus (HPV) infections, associated with the development of genital warts and malignant lesions including cervical cancer.
In order to maintain persistent infection, the HPV E2 protein associates with ChlR1 to facilitate viral genome segregation during mitosis. This project aims to study the binding interface between E2 and ChlR1 and use this information to design novel anti-viral therapeutics that could be used to treat persistent HPV infections.
contact: Dr Jo Parish
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